BGC0000002: aculeximycin biosynthetic gene cluster from Kutzneria albida DSM 43870
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Location: 7,362,971 - 7,504,512 nt. (total: 141,542 nt).
This entry is originally from NCBI GenBank CP007155.1.

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core biosynthetic genes
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General
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000002
Short description aculeximycin biosynthetic gene cluster from Kutzneria albida DSM 43870
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
CP007155.1
7362971 - 7504512
via
Compounds
  • aculeximycin
Species Kutzneria albida DSM 43870 [taxonomy]
References
Chemical products information
aculeximycin Evidence:
Copy SMILES
C81H144N2O33
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • KALB_6558
  • AHH99917.1
  • acuX1
 7362971 - 7364671 (-) AcuX1
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    • KALB_6559
    • AHH99918.1
    • acuGT8
    		 7365003 - 7366220 (-) glycosyltransferase
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      • KALB_6560
      • AHH99919.1
      • acuAVIII
      		 7366235 - 7377376 (-) PKS I
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        • KALB_6561
        • AHH99920.1
        • acuAVII
        		 7377424 - 7386327 (-) PKS I
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          • KALB_6562
          • AHH99921.1
          • acuAVI
          		 7386381 - 7409882 (-) PKS I
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            • KALB_6563
            • AHH99922.1
            • acuAV
            		 7409934 - 7423160 (-) PKS I
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              • KALB_6564
              • AHH99923.1
              • acuAIV
              		 7423185 - 7432829 (-) PKS I
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                • KALB_6565
                • AHH99924.1
                • acuAIII
                		 7432850 - 7438114 (-) PKS I
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                  • KALB_6566
                  • AHH99925.1
                  • acuAII
                  		 7438144 - 7453128 (-) PKS I
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                    • KALB_6567
                    • AHH99926.1
                    • acuAI
                    		 7453189 - 7469754 (-) PKS I
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                      • KALB_6568
                      • AHH99927.1
                      • acuO2
                      		 7469967 - 7471178 (-) cytochrome P450 hydroxylase
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                        • KALB_6569
                        • AHH99928.1
                        • acuGT7
                        		 7471171 - 7472406 (-) glycosyltransferase
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                          • KALB_6570
                          • AHH99929.1
                          • acuGT6
                          		 7472403 - 7473617 (-) glycosyltransferase
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                            • KALB_6571
                            • AHH99930.1
                            • acuS6
                            		 7473641 - 7474507 (-) glucose-1-phosphate thymidylyltransferase
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                              • KALB_6572
                              • AHH99931.1
                              • acuW
                              		 7474630 - 7476426 (-) ABC transporter protein
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                                • KALB_6573
                                • AHH99932.1
                                • acuR5
                                		 7476529 - 7477119 (+) TetR family transcription regulator
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                                  • KALB_6574
                                  • AHH99933.1
                                  • acuGT5
                                  		 7477412 - 7478632 (+) glycosyltransferase
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                                    • KALB_6575
                                    • AHH99934.1
                                    • acuGT4
                                    		 7478919 - 7480109 (-) glycosyltransferase
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                                      • KALB_6576
                                      • AHH99935.1
                                      • acuS5
                                      		 7480129 - 7480929 (-) NDP-hexose-4-ketoreductase
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                                        • KALB_6577
                                        • AHH99936.1
                                        • acuH
                                        		 7481049 - 7482659 (-) beta-hexosaminidase
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                                          • KALB_6578
                                          • AHH99937.1
                                          • acuN2
                                          		 7482946 - 7484181 (+) aminotransferase
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                                            • KALB_6579
                                            • AHH99938.1
                                            • acuGT3
                                            		 7484178 - 7485428 (+) antibiotic resistance macrolide glycosyltransferase
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                                              • KALB_6580
                                              • AHH99939.1
                                              • acuN1
                                              		 7485514 - 7486623 (+) aminotransferase
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                                                • KALB_6581
                                                • AHH99940.1
                                                • acuGT2
                                                		 7486701 - 7487948 (+) glycosyltransferase
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                                                  • KALB_6582
                                                  • AHH99941.1
                                                  • acuS4
                                                  		 7488259 - 7489725 (-) NDP-hexose 2,3-dehydratase
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                                                    • KALB_6583
                                                    • AHH99942.1
                                                    • acuS3
                                                    		 7489823 - 7490428 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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                                                      • KALB_6584
                                                      • AHH99943.1
                                                      • acuGT1
                                                      		 7490555 - 7491754 (+) glycosyltransferase
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                                                        • KALB_6585
                                                        • AHH99944.1
                                                        • acuS2
                                                        		 7491783 - 7492757 (+) dTDP-glucose 4,6-dehydratase
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                                                          • KALB_6586
                                                          • AHH99945.1
                                                          • acuR4
                                                          		 7492823 - 7493563 (-) LuxR-family transcription regulator
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                                                            • KALB_6587
                                                            • AHH99946.1
                                                            • acuO1
                                                            		 7494079 - 7494945 (+) F420 monooxygenase
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                                                              • KALB_6588
                                                              • AHH99947.1
                                                              • acuS1
                                                              		 7495132 - 7496334 (-) NDP-hexose-C3-methyltransferase
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                                                                • KALB_6589
                                                                • AHH99948.1
                                                                • acuR3
                                                                		 7496448 - 7499231 (-) LuxR-family transcription regulator
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                                                                  • KALB_6590
                                                                  • AHH99949.1
                                                                  • acuR2
                                                                  		 7499231 - 7501849 (-) LuxR-family transcription regulator
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                                                                    • KALB_6591
                                                                    • AHH99950.1
                                                                    • acuR1
                                                                    		 7501846 - 7504512 (-) LuxR-family transcription regulator
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                                                                      Biosynthesis information
                                                                      Annotation changelog

                                                                      Entry version: 4

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-10-07
                                                                      Update chemical activity to schema version 2.11
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 3

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-09-15
                                                                      Updated bioactivity data
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 2

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2019-10-16
                                                                      Migrated from v1.4
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2019-10-16
                                                                      Updated compound(s) information (NPAtlas curation)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 1

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2015-06-12
                                                                      Submitted
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      Detailed domain annotation
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