BGC0000031: borrelidin biosynthetic gene cluster from Streptomyces parvulus
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Location: 1 - 74,787 nt. (total: 74,787 nt).
This entry is originally from NCBI GenBank AJ580915.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000031
Short description borrelidin biosynthetic gene cluster from Streptomyces parvulus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolide)
Loci NCBI GenBank: AJ580915.1
Compounds
  • borrelidin
Species Streptomyces parvulus [taxonomy]
References
Chemical products information
borrelidin [synonyms: Treponemycin]
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C28H43N1O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAE45653.1
 2 - 313 (+) hypothetical protein
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  • CAE45654.1
 501 - 3107 (+) hypothetical protein
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  • CAE45655.1
 3172 - 3810 (-) hypothetical protein
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  • CAE45656.1
 3935 - 4924 (-) hypothetical protein
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  • CAE45657.1
 5123 - 5953 (+) hypothetical protein
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  • CAE45658.1
 5961 - 6518 (-) hypothetical protein
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  • CAE45659.1
 6567 - 7538 (+) hypothetical protein
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  • CAE45660.1
  • borB
 7603 - 8397 (-) thioesterase type II
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  • CAE45661.1
  • borC
 8397 - 9194 (-) putative ketoreductase
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  • CAE45662.1
  • borD
 9244 - 9996 (-) putative ketoreductase
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  • CAE45663.1
  • borE
 9993 - 11165 (-) putative muconate cyclo-isomerase/lactamase
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  • CAE45664.1
  • borF
 11162 - 11980 (-) hypothetical protein
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  • CAE45665.1
  • borG
 11992 - 13611 (-) putative acetolactate synthase
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  • CAE45666.1
  • borH
 13608 - 15659 (-) putative dehydratase
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  • CAE45667.1
  • borA1
 16184 - 18814 (+) borrelidin polyketide synthase, type I
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  • CAE45668.1
  • borA2
 18875 - 23590 (+) borrelidin polyketide synthase, type I
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  • CAE45669.1
  • borA3
 23686 - 34188 (+) borrelidin polyketide synthase, type I
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  • CAE45670.1
  • borA4
 34224 - 39047 (+) borrelidin polyketide synthase, type I
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  • CAE45671.1
  • borA5
 39044 - 45514 (+) borrelidin polyketide synthase, type I
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  • CAE45672.1
  • borA6
 45514 - 50742 (+) Borrelidin polyketide synthase, type I
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  • CAE45673.1
  • borI
 50739 - 52019 (+) putative cytochrome P450
  • Tailoring (Hydroxylation)
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  • CAE45674.1
  • borJ
 52113 - 53477 (+) putative aminotransferase
  • Tailoring (Amination)
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  • CAE45675.1
  • borK
 53474 - 54466 (+) putative oxidoreductase
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  • CAE45676.1
  • borL
 54506 - 56176 (+) hypothetical protein
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  • CAE45677.1
  • borM
 56181 - 57098 (+) putative dehydrogenase
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  • CAE45678.1
  • borN
 57112 - 57858 (+) putative 2-hydroxyhept-2,4-diene-1,7-dioate isomerase
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  • CAE45679.1
  • borO
 57939 - 59966 (+) Threonyl-tRNA synthetase
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  • CAE45680.1
 60153 - 60533 (-) hypothetical protein
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  • CAE45681.1
 60620 - 61003 (+) hypothetical protein
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  • CAE45682.1
 61188 - 61436 (+) hypothetical protein
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  • CAE45683.1
 61526 - 61738 (+) hypothetical protein
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  • CAE45684.1
 61767 - 62285 (-) hypothetical protein
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  • CAE45685.1
 62586 - >62885 (-) hypothetical protein
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  • CAE45686.1
 62885 - 63076 (-) hypothetical protein
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  • CAE45687.1
 63155 - 65071 (-) hypothetical protein
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  • CAE45688.1
 65374 - 65871 (+) hypothetical protein
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  • CAE45689.1
 65942 - 68293 (-) hypothetical protein
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  • CAE45690.1
 68290 - 68823 (-) hypothetical protein
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  • CAE45691.1
 69681 - 70436 (+) hypothetical protein
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  • CAE45692.1
 70445 - 71848 (+) hypothetical protein
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  • CAE45693.1
 71845 - 72957 (+) hypothetical protein
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  • CAE45694.1
 73037 - 73942 (+) hypothetical protein
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  • CAE45695.1
 73995 - 74537 (-) hypothetical protein
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Polyketide-specific information
Subclass Macrolide
Starter unit Trans-cyclopentane-(1R,2R)-dicarboxylic acid
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
borA4
+
borA3
+
borA2
+
borA1
+
borB
+
borA5
+
borA6 		Synthase subclass: Modular type I
Thioesterases:
  • borB (Unknown)
  • borA6 (Unknown)
Module A0
Specificity: Trans-cyclopentane-(1R, 2R)-dicarboxylic acid
Genes: borA1
Core domains: Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Malonyl-CoA
Genes: borA2
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Malonyl-CoA
Genes: borA3
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Methylmalonyl-CoA
Genes: borA3
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Methylmalonyl-CoA
Genes: borA4
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Methylmalonyl-CoA
Genes: borA5
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
Module 6
Specificity: Malonyl-CoA
Genes: borA6
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: IROSGRAECON7XFWB774QFHDN, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Removed trailing whitespace in gene names
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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