BGC0000033: calicheamicin biosynthetic gene cluster from Micromonospora echinospora
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Location: 1 - 90,348 nt. (total: 90,348 nt).
This entry is originally from NCBI GenBank AF497482.1.

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core biosynthetic genes
additional biosynthetic genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000033
Short description calicheamicin biosynthetic gene cluster from Micromonospora echinospora
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AF497482.1
via
Compounds
  • calicheamicin
Species Micromonospora echinospora [taxonomy]
References
Chemical products information
calicheamicin Evidence: NMR [1], [2], [3]
Copy SMILES
C55H74I1N3O21S4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAM94759.1
  • calU1
 1 - 873 (+) CalU1
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    • AAM94760.1
    • calU2
    		 880 - 1827 (+) CalU2
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      • AAM94761.1
      • calU3
      		 1874 - 2935 (+) CalU3
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        • AAM94762.1
        • calU4
        		 2932 - 3726 (+) CalU4
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          • AAM94763.1
          • calE1
          		 3723 - 5048 (+) CalE1
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            • AAM94764.1
            • calU5
            		 5045 - 5941 (+) CalU5
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              • AAM94765.1
              • calT1
              		 6006 - 7595 (-) CalT1
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                • AAM94766.1
                • calR1
                		 7665 - 8285 (-) CalR1
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                  • AAM94767.1
                  • calU6
                  		 8447 - 9382 (+) CalU6
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                    • AAM94768.1
                    • calS1
                    		 9415 - 9987 (-) CalS1
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                      • AAM94769.1
                      • calS2
                      		 10158 - 11081 (+) CalS2
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                        • AAM94770.1
                        • calS3
                        		 11078 - 12109 (+) CalS3
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                          • AAM94771.1
                          • calU7
                          		 12161 - 12490 (-) CalU7
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                            • AAM94772.1
                            • calS4
                            		 12764 - 13918 (+) CalS4
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                              • AAM94773.1
                              • calE2
                              		 14103 - 15017 (+) CalE2
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                                • AAM94774.1
                                • calS5
                                		 15028 - 16092 (-) CalS5
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                                  • AAM94775.1
                                  • calU8
                                  		 16249 - 16962 (+) CalU8
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                                    • AAM94776.1
                                    • calS6
                                    		 16890 - 17672 (-) CalS6
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                                      • AAM94777.1
                                      • calR2
                                      		 17960 - 19825 (+) CalR2
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                                        • AAM94778.1
                                        • calE3
                                        		 19901 - 20794 (+) CalE3
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                                          • AAM94779.1
                                          • calU9
                                          		 20791 - 21426 (+) CalU9
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                                            • AAM94780.1
                                            • calR3
                                            		 21423 - 22826 (+) CalR3
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                                              • AAM94781.1
                                              • calT2
                                              		 22968 - 24506 (-) CalT2
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                                                • AAM94782.1
                                                • calR4
                                                		 24503 - 26896 (-) CalR4
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                                                  • AAM94783.1
                                                  • calU10
                                                  		 27102 - 28304 (-) CalU10
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                                                    • AAM94784.1
                                                    • calR5
                                                    		 28696 - 30072 (-) CalR5
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                                                      • AAM94785.1
                                                      • calR6
                                                      		 30069 - 31592 (-) CalR6
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                                                        • AAM94786.1
                                                        • calE4
                                                        		 31589 - 32797 (-) CalE4
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                                                          • AAM94787.1
                                                          • calU11
                                                          		 32854 - 33672 (-) CalU11
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                                                            • AAM94788.1
                                                            • calE5
                                                            		 33669 - 34553 (-) CalE5
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                                                              • AAM94789.1
                                                              • calS7
                                                              		 34687 - 35580 (-) CalS7
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                                                                • AAM94790.1
                                                                • calU12
                                                                		 35749 - 36411 (+) CalU12
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                                                                  • AAM94791.1
                                                                  • calU13
                                                                  		 36452 - 37111 (-) CalU13
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                                                                    • AAM94792.1
                                                                    • calE6
                                                                    		 37168 - 38313 (-) CalE6
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                                                                      • AAM94793.1
                                                                      • calE7
                                                                      		 38310 - 38756 (-) CalE7
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                                                                        • AAM94794.1
                                                                        • calE8
                                                                        		 38753 - 44512 (-) CalE8
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                                                                          • AAM94795.1
                                                                          • calT3
                                                                          		 44509 - 45474 (-) CalT3
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                                                                            • AAM70329.1
                                                                            • calU14
                                                                            		 45471 - 47426 (-) CalU14
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                                                                              • AAM70330.1
                                                                              • calU15
                                                                              		 47448 - 48416 (-) CalU15
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                                                                                • AAM70331.1
                                                                                • calR7
                                                                                		 48717 - 49559 (+) CalR7
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                                                                                  • AAM70332.1
                                                                                  • calS8
                                                                                  		 49636 - 50997 (+) CalS8
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                                                                                    • AAM70333.1
                                                                                    • calS9
                                                                                    		 51004 - 51993 (+) CalS9
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                                                                                      • AAM70334.1
                                                                                      • calS10
                                                                                      		 52213 - 52950 (-) CalS10
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                                                                                        • AAM70335.1
                                                                                        • calR8
                                                                                        		 53061 - 53453 (+) CalR8
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                                                                                          • AAM70336.1
                                                                                          • calG1
                                                                                          		 53511 - 54689 (-) CalG1
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                                                                                            • AAM70337.1
                                                                                            • calS11
                                                                                            		 54904 - 55677 (+) CalS11
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                                                                                              • AAM70338.1
                                                                                              • calC
                                                                                              		 55857 - 56402 (+) CalC
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                                                                                                • AAM70339.1
                                                                                                • calU16
                                                                                                		 56411 - 56959 (+) CalU16
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                                                                                                  • AAM70340.1
                                                                                                  • calT4
                                                                                                  		 57266 - 58108 (-) CalT4
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                                                                                                    • AAM70341.1
                                                                                                    • calT5
                                                                                                    		 58105 - 59091 (-) CalT5
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                                                                                                      • AAM70342.1
                                                                                                      • calT6
                                                                                                      		 59208 - 60914 (-) CalT6
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                                                                                                        • AAM70343.1
                                                                                                        • calO1
                                                                                                        		 60938 - 61975 (-) CalO1
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                                                                                                          • AAM94796.1
                                                                                                          • calE9
                                                                                                          		 62177 - 63463 (+) CalE9
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                                                                                                            • AAM70345.1
                                                                                                            • IS
                                                                                                            		 63477 - 64685 (-) IS
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                                                                                                              • AAM70346.1
                                                                                                              • calT7
                                                                                                              		 64779 - 66461 (+) CalT7
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                                                                                                                • AAM70347.1
                                                                                                                • calR9
                                                                                                                		 66458 - 67705 (+) CalR9
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                                                                                                                  • AAM70348.1
                                                                                                                  • calG2
                                                                                                                  		 67788 - 68981 (-) CalG2
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                                                                                                                    • AAM70349.1
                                                                                                                    • calS12
                                                                                                                    		 69032 - 70024 (-) CalS12
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                                                                                                                      • AAM94797.1
                                                                                                                      • calS13
                                                                                                                      		 70221 - 71351 (+) CalS13
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                                                                                                                        • AAM94798.1
                                                                                                                        • calG3
                                                                                                                        		 71392 - 72522 (+) CalG3
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                                                                                                                          • AAM94799.1
                                                                                                                          • calO2
                                                                                                                          		 72606 - 73799 (+) CalO2
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                                                                                                                            • AAM70353.1
                                                                                                                            • calO3
                                                                                                                            		 73840 - 75102 (+) CalO3
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                                                                                                                              • AAM70354.1
                                                                                                                              • calO4
                                                                                                                              		 75152 - 76186 (+) CalO4
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                                                                                                                                • AAM70355.1
                                                                                                                                • calO5
                                                                                                                                		 76231 - 80046 (+) CalO5
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                                                                                                                                  • AAM70356.1
                                                                                                                                  • calO6
                                                                                                                                  		 80077 - 81147 (+) CalO6
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                                                                                                                                    • AAM70357.1
                                                                                                                                    • calU17
                                                                                                                                    		 81152 - 82102 (+) CalU17
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                                                                                                                                      • AAM70358.1
                                                                                                                                      • calU18
                                                                                                                                      		 82105 - 82371 (+) CalU18
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                                                                                                                                        • AAM70359.1
                                                                                                                                        • calS14
                                                                                                                                        		 82456 - 83886 (+) CalS14
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                                                                                                                                          • AAM94800.1
                                                                                                                                          • calE10
                                                                                                                                          		 84045 - 85229 (+) CalE10
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                                                                                                                                            • AAM70361.1
                                                                                                                                            • calU19
                                                                                                                                            		 85300 - 85998 (-) CalU19
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                                                                                                                                              • AAM70362.1
                                                                                                                                              • calU20
                                                                                                                                              		 86118 - 86669 (-) CalU20
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                                                                                                                                                • AAM70363.1
                                                                                                                                                • calU21
                                                                                                                                                		 86678 - 87271 (-) CalU21
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                                                                                                                                                  • AAM94801.1
                                                                                                                                                  • calU22
                                                                                                                                                  		 87351 - 88853 (-) CalU22
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                                                                                                                                                    • AAM70365.1
                                                                                                                                                    • calG4
                                                                                                                                                    		 89143 - 90348 (-) CalG4
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                                                                                                                                                      Biosynthesis information
                                                                                                                                                      Annotation changelog

                                                                                                                                                      Entry version: next

                                                                                                                                                      Date
                                                                                                                                                      Changes
                                                                                                                                                      Submitters
                                                                                                                                                      Reviewers
                                                                                                                                                      2024-06-04
                                                                                                                                                      MIBiG v4 annotathon
                                                                                                                                                      • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                                                                                                                                                      • (ID: MGLE5JJ3S32DQA3YR5WPYH4W)
                                                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                      Entry version: 4

                                                                                                                                                      Date
                                                                                                                                                      Changes
                                                                                                                                                      Submitters
                                                                                                                                                      Reviewers
                                                                                                                                                      2022-10-07
                                                                                                                                                      Update chemical activity to schema version 2.11
                                                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                      Entry version: 3

                                                                                                                                                      Date
                                                                                                                                                      Changes
                                                                                                                                                      Submitters
                                                                                                                                                      Reviewers
                                                                                                                                                      2022-09-15
                                                                                                                                                      Updated bioactivity data
                                                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                      Entry version: 2

                                                                                                                                                      Date
                                                                                                                                                      Changes
                                                                                                                                                      Submitters
                                                                                                                                                      Reviewers
                                                                                                                                                      2019-10-16
                                                                                                                                                      Migrated from v1.4
                                                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                      Entry version: 1

                                                                                                                                                      Date
                                                                                                                                                      Changes
                                                                                                                                                      Submitters
                                                                                                                                                      Reviewers
                                                                                                                                                      2015-06-12
                                                                                                                                                      Submitted
                                                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                      Detailed domain annotation
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