BGC0000034: candicidin biosynthetic gene cluster from Streptomyces sp. FR-008
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Location: 1 - 138,203 nt. (total: 138,203 nt).
This entry is originally from NCBI GenBank AY310323.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000034
Short description candicidin biosynthetic gene cluster from Streptomyces sp. FR-008
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AY310323.2
via Knock-out studies
Compounds
  • candicidin
Species Streptomyces sp. FR-008 [taxonomy]
References
Chemical products information
candicidin Evidence:
Copy SMILES
C59H84N2O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAQ82549.1
  • fscO
 574 - 1950 (-) FscO
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    • AAQ82550.2
    • pabC
    		 2264 - 3037 (-) PabC
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      • AAQ82551.1
      • fscRI
      		 3150 - 3818 (-) FscRI
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        • AAQ82552.1
        • fscRII
        		 4377 - 7205 (-) FscRII
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          • AAQ82553.1
          • fscRIII
          		 7210 - 10254 (-) FscRIII
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            • AAQ82554.1
            • fscRIV
            		 10298 - 13315 (-) FscRIV
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              • AAQ82555.1
              • fscMI
              		 13522 - 14898 (+) FscMI
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                • AAQ82556.1
                • fscMII
                		 14953 - 16011 (+) FscMII
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                  • AAQ82557.1
                  • fscP
                  		 16106 - 17287 (+) FscP
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                    • AAQ82558.1
                    • fscFE
                    		 17334 - 17528 (+) FscFE
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                      • AAQ82559.1
                      • fscTE
                      		 17556 - 18413 (+) FscTE
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                        • AAQ82560.1
                        • pabAB
                        		 18610 - 20781 (+) PabAB
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                          • AAQ82561.1
                          • fscA
                          		 20927 - 26158 (+) FscA
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                            • AAQ82562.1
                            • fscTI
                            		 26333 - 27340 (+) FscTI
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                              • AAQ82563.1
                              • fscTII
                              		 27561 - 28280 (+) FscTII
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                                • AAQ82564.1
                                • fscC
                                		 28983 - 60860 (-) FscC
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                                  • AAQ82565.1
                                  • fscB
                                  		 60962 - 77587 (-) FscB
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                                    • AAQ82566.1
                                    • fscF
                                    		 77983 - 84132 (-) FscF
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                                      • AAQ82567.1
                                      • fscE
                                      		 84170 - 107485 (-) FscE
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                                        • AAQ82568.1
                                        • fscD
                                        		 107496 - 136148 (-) FscD
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                                          • AAQ82569.1
                                          • fscMIII
                                          		 136558 - 137766 (-) FscMIII
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                                            Biosynthesis information

                                            Biosynthetic modules

                                            Name
                                            Unk01
                                            Type
                                            nrps-type1
                                            Genes
                                            fscA
                                            Substrates
                                            para-aminobenzoic acid (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Annotation changelog

                                            Entry version: 4

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Updated bioactivity data
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Added NRP substrate specificities
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Fixed biosynthetic classes
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2015-06-12
                                            Submitted
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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