BGC0000036: chlorothricin biosynthetic gene cluster from Streptomyces antibioticus
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Location: 1 - 111,968 nt. (total: 111,968 nt).
This entry is originally from NCBI GenBank DQ116941.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000036
Short description chlorothricin biosynthetic gene cluster from Streptomyces antibioticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
  • saccharide (oligosaccharide)
Loci
DQ116941.2
via Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • chlorothricin
  • deschlorothricin
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
chlorothricin [synonyms: chl] Evidence:
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C49H61Cl1O16
deschlorothricin [synonyms: deschl] Evidence:
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C49H62O16
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAZ77668.1
 1 - 672 (-) acetyltransferase
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    • AAZ77669.1
    		 890 - 1300 (-) hypothetical protein
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      • AAZ77670.1
      		 2256 - 2876 (+) unknown
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        • AAZ77671.1
        		 2986 - 3726 (-) Orf0
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          • AAZ77672.1
          		 3934 - 5169 (-) glycosyltransferase
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            • AAZ77673.1
            		 5200 - 10470 (-) type I PKS
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              • AAZ77674.1
              		 10544 - 11893 (-) flavin-dependent halogenase
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                • AAZ77675.1
                		 11913 - 12179 (-) discrete ACP
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                  • AAZ77676.1
                  		 12246 - 13289 (-) ketoacyl-ACP synthase; condensing protein
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                    • AAZ77677.1
                    		 13337 - 13750 (-) ChlH
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                      • AAZ77678.1
                      		 13782 - 14498 (+) O-methyltransferase
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                        • AAZ77679.1
                        		 14736 - 15794 (+) ketoacyl-ACP synthase; condensing protein
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                          • AAZ77680.1
                          		 15865 - 16608 (-) 4-ketoreductase
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                            • AAZ77681.1
                            		 16671 - 17666 (-) 3-ketoreductase
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                              • AAZ77682.1
                              		 17698 - 19014 (-) 2,3-dehydratase
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                                • AAZ77683.1
                                		 19162 - 19374 (-) coupling protein of carboxyl transferase
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                                  • AAZ77684.1
                                  		 19395 - 21002 (-) ChlJ
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                                    • AAZ77685.1
                                    		 21139 - 21747 (+) transcriptional regulator
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                                      • AAZ77686.1
                                      		 21904 - 23370 (+) export protein
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                                        • AAZ77687.1
                                        		 23585 - 24370 (-) response regulator of 2-component system
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                                          • AAZ77688.1
                                          		 24379 - 25179 (-) type II TE
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                                            • AAZ77689.1
                                            		 26081 - 27064 (-) dDNP-glucose-4,6-dehydratase
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                                              • AAZ77690.1
                                              		 27078 - 28145 (-) dDNP-glucose synthase
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                                                • AAZ77691.1
                                                		 28263 - 29477 (-) glycosyltransferase
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                                                  • AAZ77692.1
                                                  		 29807 - 31357 (+) FAD-dependent oxygenase
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                                                    • AAZ77693.1
                                                    		 31481 - 45580 (+) type I PKS
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                                                      • AAZ77694.1
                                                      		 45580 - 57447 (+) type I PKS
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                                                        • AAZ77695.1
                                                        		 57522 - 58718 (+) cytochrome P450 hydroxylase
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                                                          • AAZ77696.1
                                                          		 58888 - 76044 (+) type I PKS
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                                                            • AAZ77697.1
                                                            		 76074 - 81635 (+) type I PKS
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                                                              • AAZ77698.1
                                                              		 81667 - 93477 (+) type I PKS
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                                                                • AAZ77699.1
                                                                		 93554 - 98305 (+) type I PKS
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                                                                  • AAZ77700.1
                                                                  		 98302 - 99798 (+) FAD-dependent oxygenase
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                                                                    • AAZ77701.1
                                                                    		 99866 - 100441 (-) ribosomal protein L15P
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                                                                      • AAZ77702.1
                                                                      		 100612 - 101739 (+) 3-oxoacyl-ACP synthase III
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                                                                        • AAZ77703.1
                                                                        		 101743 - 103698 (+) ChlD1
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                                                                          • AAZ77704.1
                                                                          		 103695 - 103922 (+) discrete ACP
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                                                                            • AAZ77705.1
                                                                            		 103919 - 104734 (+) pyruvate/2-oxoglutarate dehydrogenase
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                                                                              • AAZ77706.1
                                                                              		 104713 - 105801 (+) predicted hydrolase or acyltransferase
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                                                                                • AAZ77707.1
                                                                                		 106089 - 106484 (-) peptidase M20
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                                                                                  • ABI35990.1
                                                                                  		 107684 - 110125 (-) putative helicase
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                                                                                    • ABI35989.1
                                                                                    		 110144 - 111268 (-) ankyrin
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                                                                                      • ABI35991.1
                                                                                      		 111482 - >111967 (-) tankyrase1-binding protein
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                                                                                        Biosynthesis information

                                                                                        Biosynthetic modules

                                                                                        Name
                                                                                        0
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77693.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                                                        Name
                                                                                        1
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77693.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                        Name
                                                                                        2
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77693.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                        Name
                                                                                        3
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77694.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                        Name
                                                                                        4
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77694.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                                                        Name
                                                                                        5
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77696.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                                                        Name
                                                                                        6
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77696.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                        Name
                                                                                        7
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77696.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                        Name
                                                                                        8
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77697.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                        Name
                                                                                        9
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77698.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                                                        Name
                                                                                        10
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77698.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                        Name
                                                                                        11
                                                                                        Type
                                                                                        pks-modular
                                                                                        Genes
                                                                                        AAZ77699.1
                                                                                        Substrates
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                                                        Annotation changelog

                                                                                        Entry version: next

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2024-05-14
                                                                                        MIBiG v4 annotathon
                                                                                        • (ID: NHJ6M55E7ZEHUFNMEG4QIZWY)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 4

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-10-07
                                                                                        Update chemical activity to schema version 2.11
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 3

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-09-15
                                                                                        Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        2022-09-15
                                                                                        Corrected gene identifiers
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 2

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2019-10-16
                                                                                        Migrated from v1.4
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 1

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2015-06-12
                                                                                        Submitted
                                                                                        • (ID: FEQLSWI73YICHNTDWNWMD3JQ)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        Detailed domain annotation
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