BGC0000036: chlorothricin biosynthetic gene cluster from Streptomyces antibioticus
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Location: 1 - 111,968 nt. (total: 111,968 nt).
This entry is originally from NCBI GenBank DQ116941.2.

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core biosynthetic genes
additional biosynthetic genes
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TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000036
Short description chlorothricin biosynthetic gene cluster from Streptomyces antibioticus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolide)
  • Saccharide (oligosaccharide)
Loci NCBI GenBank: DQ116941.2
Compounds
  • chlorothricin
  • deschlorothricin
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
chlorothricin [synonyms: chl]
Copy SMILES
C49H61Cl1O16
deschlorothricin [synonyms: deschl]
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C49H62O16
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAZ77668.1
 1 - 672 (-) acetyltransferase
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  • AAZ77669.1
 890 - 1300 (-) hypothetical protein
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  • AAZ77670.1
 2256 - 2876 (+) unknown
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  • AAZ77671.1
 2986 - 3726 (-) Orf0
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  • AAZ77672.1
 3934 - 5169 (-) ChlC7
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  • AAZ77673.1
 5200 - 10470 (-) ChlB1
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  • AAZ77674.1
 10544 - 11893 (-) ChlB4
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  • AAZ77675.1
 11913 - 12179 (-) ChlB2
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  • AAZ77676.1
 12246 - 13289 (-) ChlB3
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  • AAZ77677.1
 13337 - 13750 (-) ChlH
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  • AAZ77678.1
 13782 - 14498 (+) ChlB5
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  • AAZ77679.1
 14736 - 15794 (+) ChlB6
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  • AAZ77680.1
 15865 - 16608 (-) ChlC5
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  • AAZ77681.1
 16671 - 17666 (-) ChlC4
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  • AAZ77682.1
 17698 - 19014 (-) ChlC3
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  • AAZ77683.1
 19162 - 19374 (-) ChlI
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  • AAZ77684.1
 19395 - 21002 (-) ChlJ
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  • AAZ77685.1
 21139 - 21747 (+) ChlF1
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  • AAZ77686.1
 21904 - 23370 (+) ChlG
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  • AAZ77687.1
 23585 - 24370 (-) ChlF2
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  • AAZ77688.1
 24379 - 25179 (-) ChlK
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  • AAZ77689.1
 26081 - 27064 (-) ChlC2
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  • AAZ77690.1
 27078 - 28145 (-) ChlC1
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  • AAZ77691.1
 28263 - 29477 (-) ChlC6
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  • AAZ77692.1
 29807 - 31357 (+) ChlE1
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  • AAZ77693.1
 31481 - 45580 (+) ChlA1
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  • AAZ77694.1
 45580 - 57447 (+) ChlA2
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  • AAZ77695.1
 57522 - 58718 (+) ChlE2
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  • AAZ77696.1
 58888 - 76044 (+) ChlA3
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  • AAZ77697.1
 76074 - 81635 (+) ChlA4
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  • AAZ77698.1
 81667 - 93477 (+) ChlA5
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  • AAZ77699.1
 93554 - 98305 (+) ChlA6
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  • AAZ77700.1
 98302 - 99798 (+) ChlE3
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  • AAZ77701.1
 99866 - 100441 (-) ChlL
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  • AAZ77702.1
 100612 - 101739 (+) ChlM
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  • AAZ77703.1
 101743 - 103698 (+) ChlD1
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  • AAZ77704.1
 103695 - 103922 (+) ChlD2
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  • AAZ77705.1
 103919 - 104734 (+) ChlD3
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  • AAZ77706.1
 104713 - 105801 (+) ChlD4
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  • AAZ77707.1
 106089 - 106484 (-) peptidase M20
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  • ABI35990.1
 107684 - 110125 (-) putative helicase
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  • ABI35989.1
 110144 - 111268 (-) ankyrin
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  • ABI35991.1
 111482 - >111967 (-) tankyrase1-binding protein
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Polyketide-specific information
Subclass Macrolide
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Claisen condensation
Polyketide-synthases
Genes Properties Modules
AAZ77693.1
+
AAZ77697.1
+
AAZ77698.1
+
AAZ77696.1
+
AAZ77673.1
+
AAZ77694.1
+
AAZ77699.1 		Synthase subclass: Modular type I/Iterative type I
Iterative PKS type: Partially reducing, C2-C7 first
Iteration counts: 2
Module 0
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77693.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77693.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77693.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77694.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77694.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77696.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 6
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77696.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77696.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 8
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77697.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 9
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77698.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 10
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77698.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 11
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AAZ77699.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Saccharide-specific information
Subclass oligosaccharide
Glycosyltransferases
AAZ77691.1
Evidence:
  • Sequence-based prediction
AAZ77672.1
Evidence:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FEQLSWI73YICHNTDWNWMD3JQ, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected gene identifiers
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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