BGC0000042: cremimycin biosynthetic gene cluster from Streptomyces sp. MJ635-86F5
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Location: 1 - 105,855 nt. (total: 105,855 nt).
This entry is originally from NCBI GenBank AB818354.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000042
Short description cremimycin biosynthetic gene cluster from Streptomyces sp. MJ635-86F5
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AB818354.1
Compounds
  • cremimycin
Species Streptomyces sp. MJ635-86F5 [taxonomy]
References
Chemical products information
cremimycin
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C35H53N1O9
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAO66509.1
 7 - 1047 (-) SAM-dependent methyltransferase
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  • BAO66510.1
 1119 - 1610 (-) putative transcriptional regulator
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  • BAO66511.1
 1638 - 2312 (-) phosphopantetheinyl transferase
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  • BAO66512.1
 2309 - 3163 (-) metallophosphatase
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  • BAO66513.1
  • cmiC1
 3580 - 4350 (-) dTDP-6-deoxy-L-hexose-3-O-methyltransferase
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  • BAO66514.1
  • cmiC2
 4365 - 5408 (-) 4-ketoreductase
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  • BAO66515.1
  • cmiM1
 5489 - 6367 (-) retinol dehydrogenase
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  • BAO66516.1
  • cmiM2
 6364 - 7230 (-) xylose isomerase
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  • BAO66517.1
  • cmiR1
 7441 - 8211 (+) type II thioesterase
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  • BAO66518.1
  • cmiC3
 8269 - 8859 (+) dTDP-4-deoxyglucose 3,5-epimerase
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  • BAO66519.1
  • cmiP1
 8973 - 19733 (-) type I polyketide synthase
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  • BAO66520.1
  • cmiR2
 20047 - 20802 (-) TetR-type transcriptional regulator
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  • BAO66521.1
  • cmiR3
 21016 - 21996 (+) ABC transporter
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  • BAO66522.1
  • cmiR4
 21993 - 22838 (+) ABC transporter
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  • BAO66523.1
  • cmiM3
 22990 - 23856 (+) carveol dehydrogenase
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  • BAO66524.1
  • cmiM4
 23963 - 25201 (-) P450 monooxygenase
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  • BAO66525.1
  • cmiS1
 25426 - 26001 (+) putative NRPS accessory protein
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  • BAO66526.1
  • cmiP2
 26009 - 28183 (+) type I polyketide synthase
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  • BAO66527.1
  • cmiS2
 28258 - 29385 (+) FAD-dependent glycine oxydase
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  • BAO66528.1
  • cmiP3
 29390 - 32524 (-) type I polyketide synthase
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  • BAO66529.1
  • cmiP4
 32555 - 48247 (-) type I polyketide synthase
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  • BAO66530.1
  • cmiS3
 48180 - 49730 (-) nonribosomal peptide synthase
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  • BAO66531.1
  • cmiS4
 49840 - 50076 (+) peptidyl carrier protein
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  • BAO66532.1
  • cmiS5
 50151 - 51104 (-) acyltransferase
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  • BAO66533.1
  • cmiS6
 51284 - 52867 (+) nonribosomal peptide synthase
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  • BAO66534.1
  • cmiM5
 53013 - 54254 (+) glycosyltransferase
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  • BAO66535.1
  • cmiC4
 54261 - 55259 (-) 3-ketoreductase
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  • BAO66536.1
  • cmiC5
 55256 - 56794 (-) NDP-hexose 2,3-dehydratase
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  • BAO66537.1
  • cmiC6
 56791 - 57789 (-) dTDP-glucose 4,6-dehydratase
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  • BAO66538.1
  • cmiC7
 57786 - 58850 (-) NDP-1-glucose synthase
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  • BAO66539.1
  • cmiP5
 59120 - 67081 (-) type I polyketide synthase
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  • BAO66540.1
  • cmiM6
 67126 - 68019 (-) putative proline iminopeptidase
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  • BAO66541.1
  • cmiP6
 68036 - 74047 (-) type I polyketide synthase
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  • BAO66542.1
  • cmiP7
 74047 - 89649 (-) type I polyketide synthase
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  • BAO66543.1
  • cmiP8
 89683 - 94560 (-) type I polyketide synthase
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  • BAO66544.1
  • cmiM7
 94586 - 95455 (-) xylose isomerase
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  • BAO66545.1
  • cmiR5
 95624 - 98380 (-) LuxR-type transcriptional regulator
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  • BAO66546.1
 98983 - 101670 (+) LuxR-type transcriptional regulator
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  • BAO66547.1
 102133 - 103728 (-) cyclohexanecarboxylate-CoA ligase
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  • BAO66548.1
 104317 - 105777 (-) purine cytosine permease
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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