BGC0000054: erythromycin biosynthetic gene cluster from Aeromicrobium erythreum
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Location: 1 - 61,845 nt. (total: 61,845 nt).
This entry is originally from NCBI GenBank AY623658.2.

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core biosynthetic genes
additional biosynthetic genes
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General
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000054
Short description erythromycin biosynthetic gene cluster from Aeromicrobium erythreum
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AY623658.2
Compounds
  • erythromycin
Species Aeromicrobium erythreum [taxonomy]
References
Chemical products information
erythromycin
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C37H67N1O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAU93784.2
 228 - 869 (-) putative transcriptional repressor
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  • AAU93785.1
 925 - 1746 (+) putative dehydrogenase/reductase
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  • AAU93786.2
 2172 - 2729 (+) unknown
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  • AAU93787.1
  • eryD1
 2920 - 3813 (+) dTDP-glucose synthase
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  • AAU93788.2
  • eryC1
 3822 - 4937 (+) transaminase
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  • AAU93789.1
  • eryBVII
 4934 - 5527 (-) dTDP-4-keto-6-deoxyglucose 3,5-epimerase
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  • AAU93790.1
  • eryCV
 5530 - 6969 (-) deoxyhexose reductase
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  • AAU93791.1
  • eryCIV
 6997 - 8202 (-) deoxyhexose dehydratase
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  • AAU93792.1
  • eryBVI
 8199 - 9635 (-) deoxyhexose dehydratase
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  • AAU93793.1
  • eryTII
 9706 - 10446 (-) thioesterase type II
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  • AAU93794.1
  • eryP
 10443 - 11132 (-) phosphopantetheinyl transferase
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  • AAU93795.1
  • eryK
 11160 - 12323 (-) erythromycin C-12 hydroxylase
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  • AAU93796.1
  • ermR
 12450 - 13472 (+) ribosomal RNA methyltransferase
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  • AAU93797.1
  • eryBI
 13469 - 15913 (-) beta-glucosidase
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  • AAU93798.1
  • eryBIII
 16039 - 17274 (+) methyltransferase
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  • AAU93799.1
  • eryF
 17271 - 18491 (+) cytochrome P450 oxidoreductase
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  • AAU93800.1
  • eryTI
 18495 - 19229 (+) thioesterase
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  • AAU93801.1
  • eryG
 19226 - 20140 (-) methylase
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  • AAU93802.1
  • eryBII
 20203 - 21198 (-) deoxyhexose reductase
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  • AAU93803.1
  • eryCIII
 21195 - 22466 (-) L-desosaminyltransferase
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  • AAU93804.1
  • eryCII
 22468 - 23553 (-) deoxyhexose isomerase
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  • AAU93805.2
  • eryAIII
 23550 - 33137 (-) polyketide synthase modules 5 and 6
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  • AAU93806.2
  • eryAII
 33185 - 43909 (-) polyketide synthase modules 3 and 4
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  • AAU93807.2
  • eryAI
 43959 - 54545 (-) polyketide synthase modules 1 and 2
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  • AAU93808.1
  • eryBIV
 54874 - 55818 (+) deoxyhexose dehydratase
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  • AAU93809.2
  • eryBV
 55820 - 57058 (+) L-mycarosyltransferase
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  • AAU93810.1
  • eryCVI
 57099 - 57815 (+) N-methyltransferase
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  • AAU93811.1
 57857 - 58300 (-) marR family transcriptional regulator
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  • AAU93812.1
 58328 - 59569 (-) putative oxidoreductase
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  • AAU93813.2
 59714 - 60817 (+) LipN
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  • AAU93814.2
 60814 - >61845 (+) monoamine oxidase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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