BGC0000059: filipin biosynthetic gene cluster from Streptomyces avermitilis MA-4680 = NBRC 14893
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Location: 486,648 - 567,017 nt. (total: 80,370 nt).
This entry is originally from NCBI GenBank BA000030.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
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General
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000059
Short description filipin biosynthetic gene cluster from Streptomyces avermitilis MA-4680 = NBRC 14893
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: BA000030.3
Compounds
  • filipin
Species Streptomyces avermitilis MA-4680 = NBRC 14893 [taxonomy]
References
Chemical products information
filipin
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C35H58O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAV_407
  • BAC68117.1
  • pteH
 486648 - 487415 (-) thioesterase
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  • SAV_408
  • BAC68118.1
  • pteG
 487512 - 489155 (-) putative cholesterol oxidase
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  • SAV_409
  • BAC68119.1
  • pteF
 489621 - 490319 (-) putative LuxR-family transcriptional regulator
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  • SAV_410
  • BAC68120.2
  • pteR
 490599 - 494192 (+) DnrI/RedD/AfsR-family transcriptional regulator
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  • SAV_411
  • BAC68121.1
  • pteE
 494248 - 494442 (-) ferredoxin
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  • SAV_412
  • BAC68122.2
  • pteD
 494487 - 495701 (-) cytochrome P450 hydroxylase
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  • SAV_413
  • BAC68123.1
  • pteC
 496283 - 497482 (-) cytochrome P450 hydroxylase
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  • SAV_414
  • BAC68124.1
  • pteB
 497529 - 498785 (-) putative dehydrogenase
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  • SAV_415
  • BAC68125.1
  • pteA5
 498846 - 508904 (-) modular polyketide synthase
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  • SAV_416
  • BAC68126.1
  • pteA4
 508951 - 527388 (-) modular polyketide synthase
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  • SAV_417
  • BAC68127.1
  • pteA3
 527468 - 532975 (-) modular polyketide synthase
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  • SAV_418
  • BAC68128.1
  • pteA2
 533011 - 543705 (-) modular polyketide synthase
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  • SAV_419
  • BAC68129.1
  • pteA1
 543777 - 567017 (-) modular polyketide synthase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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