BGC0000087: lasalocid biosynthetic gene cluster from Streptomyces lasaliensis
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Location: 1 - 110,927 nt. (total: 110,927 nt).
This entry is originally from NCBI GenBank FM173265.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000087
Short description lasalocid biosynthetic gene cluster from Streptomyces lasaliensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: FM173265.1
Compounds
  • lasalocid
Species Streptomyces lasaliensis [taxonomy]
References
Chemical products information
lasalocid
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C34H53Na1O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAQ64671.1
 317 - 1129 (-) hypothetical protein
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  • CAQ64672.1
 1471 - 2379 (-) Ku70/Ku80 protein
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  • CAQ64673.1
 2632 - 3312 (-) putative secreted protein
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  • CAQ64674.1
 3605 - 5002 (-) putative MFS-type efflux protein
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  • pseudo5478_6051
 5479 - 6051 (+)
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  • CAQ64676.1
 6061 - 7269 (-) IS10 transposase
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  • pseudo7374_7788
 7375 - 7788 (+)
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  • pseudo7897_9088
 7898 - 9088 (+)
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  • pseudo9093_9519
 9094 - 9519 (+)
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  • CAQ64680.1
  • las1
 9538 - 10287 (-) thioesterase
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  • CAQ64681.1
  • las2
 10490 - 12046 (-) putative resistance protein, transporter
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  • CAQ64682.1
  • las3
 12178 - 12663 (+) putative transcriptional regulator
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  • CAQ64683.1
  • las4
 13216 - 15954 (+) LuxR-family transcriptional regulator
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  • CAQ64684.1
  • las5
 15965 - 17329 (+) crotonyl-CoA reductase
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  • CAQ64685.1
  • las6
 17453 - 19174 (-) 3-hydroxyacyl-CoA dehydrogenase
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  • CAQ64686.1
  • lasAI
 19470 - 34430 (+) lasalocid modular polyketide synthase
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  • CAQ64687.1
  • lasAII
 34479 - 50888 (+) lasalocid modular polyketide synthase
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  • CAQ64688.1
  • lasAIII
 50932 - 54258 (+) lasalocid modular polyketide synthase
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  • CAQ64689.1
  • lasAIV
 54322 - 59265 (+) lasalocid modular polyketide synthase
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  • CAQ64690.1
  • lasAV
 59390 - 70429 (+) lasalocid modular polyketide synthase
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  • CAQ64691.1
  • lasAVI
 70541 - 76174 (+) lasalocid modular polyketide synthase
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  • CAQ64692.1
  • lasAVII
 76171 - 80106 (+) lasalocid modular polyketide synthase
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  • CAQ64693.1
  • las7
 80229 - 80597 (-) hypothetical protein
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  • CAQ64694.1
  • lasC
 80792 - 82210 (+) tetronomycin epoxidase
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  • CAQ64695.1
  • lasB
 82223 - 83071 (+) epoxide hydrolase
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  • CAQ64696.1
 83421 - 84350 (+) serine-type D-Ala-D-Ala carboxypeptidase
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  • CAQ64697.1
 84406 - 85167 (-) hypothetical protein
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  • CAQ64698.1
 85247 - 85972 (+) hypothetical protein
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  • CAQ64699.1
 86050 - 86265 (-) hypothetical protein
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  • CAQ64700.1
 86553 - 87341 (+) hypothetical protein
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  • CAQ64701.1
 87418 - 88023 (-) TetR family transcriptional regulator
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  • CAQ64702.1
 88177 - 88923 (+) probable glucose dehydrogenase
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  • CAQ64703.1
 89074 - 89643 (+) hypothetical protein
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  • CAQ64704.1
 89789 - 90247 (+) hypothetical protein
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  • CAQ64705.1
 90282 - 91271 (-) peptidase U61 LD-carboxypeptidase A
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  • CAQ64706.1
 91714 - 91944 (+) hypothetical protein
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  • CAQ64707.1
 92100 - 92255 (-) hypothetical protein
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  • CAQ64708.1
 92919 - 93482 (-) TetR family transcriptional regulator
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  • CAQ64709.1
 93475 - 94311 (-) hydrolase
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  • CAQ64710.1
 94763 - 95233 (+) hypothetical protein
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  • CAQ64711.1
 95386 - 95733 (+) hypothetical protein
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  • CAQ64712.1
 96014 - 96328 (-) hypothetical protein
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  • CAQ64713.1
 96688 - 97188 (-) cupin domain protein
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  • CAQ64714.1
 97517 - 98020 (-) MarR family transcriptional regulator
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  • CAQ64715.1
 98348 - 99292 (+) alcohol dehydrogenase zinc-binding domain protein
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  • CAQ64716.1
 99585 - 100478 (-) AraC family transcriptional regulator
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  • CAQ64717.1
 101038 - 104343 (+) glycoside hydrolase family 2, sugar binding
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  • CAQ64718.1
 104531 - 105610 (+) sugar ABC transporter, solute-binding protein
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  • CAQ64719.1
  • rbsA
 105689 - 107377 (+) sugar uptake ABC transporter, ATP-binding protein
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  • CAQ64720.1
 107374 - 108342 (+) sugar uptake ABC transporter, permease protein
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  • CAQ64721.1
  • rbsC
 108339 - 109364 (+) sugar ABC transporter, permease protein
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  • CAQ64722.1
 109429 - 110445 (+) LacI-family transcriptional regulator
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  • CAQ64723.1
  • adpA
 110467 - >110925 (-) AraC family transcriptional regulator
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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