BGC0000092: megalomicin A biosynthetic gene cluster from Micromonospora megalomicea subsp. nigra
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Location: 1 - 47,981 nt. (total: 47,981 nt).
This entry is originally from NCBI GenBank AF263245.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
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Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000092
Short description megalomicin A biosynthetic gene cluster from Micromonospora megalomicea subsp. nigra
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AF263245.1
via
Compounds
  • megalomicin A
  • megalomicin B
  • megalomicin C1
  • megalomicin C2
Species Micromonospora megalomicea subsp. nigra [taxonomy]
References
Chemical products information
megalomicin A Evidence:
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C44H80N2O15
Chemical database entries
PubCHEM
megalomicin B Evidence:
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C46H82N2O16
Chemical database entries
PubCHEM
megalomicin C1 Evidence:
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C48H84N2O17
Chemical database entries
PubCHEM
megalomicin C2 Evidence:
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C49H86N2O17
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAG13906.1
  • megT
 <1 - 144 (-) TDP-4-keto-6-deoxyglucose-2,3-dehydratase
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    • AAG13907.1
    • megDVI
    		 928 - 2061 (+) TDP-4-keto-6-deoxyhexose 3,4-isomerase
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      • AAG13908.1
      • megDI
      		 2072 - 3382 (+) TDP-megosamine glycosyltransferase
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        • AAG13909.1
        • megY
        		 3462 - 4634 (+) mycarose O-acyltransferase
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          • AAG13910.1
          • megDII
          		 4651 - 5775 (+) TDP-3-keto-6-deoxyhexose 3-aminotransaminase
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            • AAG13912.1
            • megDIII
            		 5822 - 6595 (+) daunosaminyl-N,N-dimethyltransferase
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              • AAG13911.1
              • megDIV
              		 6592 - 7197 (+) TDP-4-keto-6-deoxyhexose 3,5-epimerase
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                • AAG13913.1
                • megDV
                		 7220 - 8206 (+) TDP-4-keto-6-deoxyhexose 4-ketoreductase
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                  • AAG13914.1
                  • megDVII
                  		 8228 - 9220 (-) TDP-4-keto-6-deoxyhexose 2,3-reductase
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                    • AAG13915.1
                    • megBV
                    		 9226 - 10479 (-) TDP-mycarose glycosyltransferase
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                      • AAG13916.1
                      • megBIV
                      		 10483 - 11424 (-) TDP-4-keto-6-deoxyhexose 4-ketoreductase
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                        • AAG13917.1
                        • megAI
                        		 12181 - 22821 (+) megalomicin 6-deoxyerythronolide B synthase 1
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                          • AAG13918.1
                          • megAII
                          		 22867 - 33555 (+) megalomicin 6-deoxyerythronolide B synthase 2
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                            • AAG13919.1
                            • megAIII
                            		 33666 - 43271 (+) megalomicin 6-deoxyerythronolide B synthase 3
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                              • AAG13920.1
                              • megCII
                              		 43268 - 44344 (+) TDP-4-keto-6-deoxyglucose 3,4-isomerase
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                                • AAG13921.1
                                • megCIII
                                		 44355 - 45623 (+) TDP-desosamine glycosyltransferase
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                                  • AAG13922.1
                                  • megBII
                                  		 45620 - 46591 (+) TDP-4-keto-6-deoxyglucose 2,3 dehydratase
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                                    • AAG13923.1
                                    • megH
                                    		 46660 - 47403 (-) TEII
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                                      • AAG13924.1
                                      • megF
                                      		 47411 - >47979 (-) C-6 hydroxylase
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                                        Biosynthesis information

                                        No biosynthesis information available for this record.

                                        Annotation changelog

                                        Entry version: 4

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-10-07
                                        Update chemical activity to schema version 2.11
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 3

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-09-15
                                        Updated bioactivity data
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 2

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2019-10-16
                                        Migrated from v1.4
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2019-10-16
                                        Updated compound(s) information (MIBiG Annotathon)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 1

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2015-06-12
                                        Submitted
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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