BGC0000093: meilingmycin biosynthetic gene cluster from Streptomyces nanchangensis
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Location: 1 - 185,250 nt. (total: 185,250 nt).
This entry is originally from NCBI GenBank FJ952082.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000093
Short description meilingmycin biosynthetic gene cluster from Streptomyces nanchangensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: FJ952082.1
Compounds
  • meilingmycin
Species Streptomyces nanchangensis [taxonomy]
References
Chemical products information
meilingmycin
Copy SMILES
C36H52O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADC45511.1
 1 - 1337 (-) Na+/H+ antiporter
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  • ADC45512.1
 1603 - 2280 (-) intracellular protease/amidase
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  • ADC45513.1
 2432 - 3331 (+) LysR-family transcriptional regulator
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  • ADC45514.1
 3487 - 4683 (+) cytochrome P450
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  • ADC45515.1
  • pks2
 4699 - 10563 (-) modular polyketide synthase
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  • ADC45516.1
  • pks1
 10556 - 17425 (-) modular polyketide synthase
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  • ADC45517.1
 17671 - 19389 (+) AMP-dependent synthetase and ligase
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  • ADC45518.1
 19386 - 20252 (+) hypothetical protein
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  • ADC45519.1
 20249 - 20779 (+) thioesterase
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  • ADC45520.1
 20776 - 21066 (+) acyl carrier protein
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  • ADC45521.1
 21063 - 21932 (+) cyclopropane-fatty-acyl-phospholipid synthase
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  • ADC45522.1
 21929 - 22801 (+) acyl-[acyl-carrier protein] desaturase
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  • ADC45523.1
 22816 - 24429 (-) secreted amidase
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  • ADC45524.1
 24504 - 25007 (-) hypothetical protein
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  • ADC45525.1
 25161 - 27209 (+) alpha-glucuronidase
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  • ADC45526.1
 27238 - 31071 (-) hypothetical protein
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  • ADC45527.1
 31153 - 32580 (-) gluconate transporter
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  • ADC45528.1
 32668 - 33654 (-) hypothetical protein
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  • ADC45529.1
 33753 - 35426 (+) two-component system histidine kinase
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  • ADC45530.1
 35423 - 36115 (+) two-component system response regulator
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  • ADC45531.1
 36139 - 37263 (-) hypothetical protein
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  • ADC45532.1
 37274 - 37849 (-) heavy metal translocating P-type ATPase
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  • ADC45533.1
 38044 - 39195 (+) hypothetical protein
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  • ADC45534.1
  • meiA2
 39452 - 57415 (+) modular polyketide synthase
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  • AAM97313.1
  • meiC
 57429 - 58421 (+) post-polyketide modification protein
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  • AAM97314.1
  • meiE
 58480 - 59859 (-) cytochrome P450 hydroxylase
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  • ADC45535.1
  • meiA4
 59936 - 75769 (-) modular polyketide synthase
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  • ADC45536.1
 76029 - 76829 (+) reductase
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  • AAP13848.2
  • meiF
 76867 - 77679 (-) C5-ketoreductase
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  • ADC45537.1
 77846 - 78601 (-) hypothetical protein
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  • ADC45538.1
  • meiA3
 78606 - 96074 (-) modular polyketide synthase
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  • ADC45539.1
  • meiR
 96121 - 99015 (-) LuxR-family transcriptional regulator
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  • ADC45540.1
 99318 - 100469 (+) hypothetical protein
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  • ADC45541.1
 100671 - 102113 (+) beta-lactamase-like protein
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  • ADC45542.1
 102173 - 103669 (-) Na+/solute symporter
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  • ADC45543.1
 103666 - 103896 (-) hypothetical protein
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  • ADC45544.1
 104276 - 104656 (+) hypothetical protein
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  • ADC45545.1
 104656 - 105486 (+) hydroxypyruvate isomerase
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  • ADC45546.1
 105556 - 106452 (+) 2-hydroxy-3-oxopropionate reductase
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  • ADC45547.1
 106518 - 108287 (+) glyoxylate carboligase
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  • ADC45548.1
 108318 - 109508 (-) mandelate racemase
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  • ADC45549.1
 109505 - 110284 (-) 5-carboxymethyl-2-hydroxymuconate delta-isomerase
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  • ADC45550.1
 110464 - 111825 (-) anion/cation symporter
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  • ADC45551.1
 112100 - 112885 (+) dimethylmenaquinone methyltransferase
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  • ADC45552.1
 112882 - 113391 (+) hypothetical protein
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  • ADC45553.1
 113420 - 114931 (+) aldehyde dehydrogenase
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  • ADC45554.1
 114915 - 115772 (-) aldose 1-epimerase
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  • ADC45555.1
 115938 - 117386 (+) sugar transporter
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  • ADC45556.1
 117383 - 118279 (+) 2-hydroxycyclohexanecarboxyl-CoA dehyrogenase
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  • ADC45557.1
 118276 - 119445 (+) isomerase
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  • ADC45558.1
 119490 - 120278 (-) transcriptional regulator
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  • ADC45559.1
 120722 - 121447 (-) acetyl-xylan esterase
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  • ADC45560.1
 121600 - 122463 (-) citrate lyase beta subunit
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  • ADC45561.1
 122516 - 123400 (-) hypothetical protein
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  • ADC45562.1
 123478 - 124077 (-) sulfopyruvate decarboxylase beta subunit
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  • ADC45563.1
 124077 - 124613 (-) sulfopyruvate decarboxylase alpha subunit
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  • ADC45564.1
 124725 - 125549 (-) hydrolase
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  • ADC45565.1
 125629 - 126582 (-) LysR-family transcriptional regulator
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  • ADC45566.1
 126703 - 127887 (+) L-carnitine dehydratase
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  • ADC45567.1
 127932 - 129095 (+) acyl-CoA dehydrogenase
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  • ADC45568.1
 129165 - 132380 (-) rhamnosidase
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  • ADC45569.1
 132620 - 132940 (-) hypothetical protein
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  • ADC45570.1
 133101 - 133751 (-) transcriptional regulator
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  • ADC45571.1
 133941 - 134603 (+) hypothetical protein
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  • ADC45572.1
 134605 - 135198 (-) TetR-family transcriptional regulator
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  • ADC45573.1
 135388 - 136407 (+) aldoketoreductase
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  • ADC45574.1
 136478 - 137323 (+) flavin-dependent oxidoreductase
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  • ADC45575.1
 137355 - 138866 (-) hydrolase
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  • ADC45576.1
 139224 - 140276 (+) hypothetical protein
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  • ADC45577.1
 140258 - 141583 (+) hypothetical protein
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  • ADC45578.1
 141628 - 142818 (+) lysine/ornithine decarboxylase
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  • ADC45579.1
 142827 - 143357 (+) hypothetical protein
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  • ADC45580.1
 143354 - 144553 (+) transmembrane transport protein
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  • ADC45581.1
 144519 - 145820 (-) glycoside hydrolase
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  • ADC45582.1
 145963 - 148932 (-) hypothetical protein
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  • ADC45583.1
 149148 - 150152 (+) sugar-binding transcriptional regulator
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  • ADC45584.1
 150307 - 152142 (+) monooxygenase
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  • ADC45585.1
 152139 - 153836 (+) hypothetical protein
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  • ADC45586.1
  • meiA1
 154052 - 167044 (+) modular polyketide synthase
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  • ADC45587.1
  • meiD
 167087 - 167947 (+) C5-O-methyltransferase
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  • ADC45588.1
 167960 - 171655 (-) hydrolase
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  • ADC45589.1
 171713 - 172498 (-) short-chain dehydrogenase/reductase SDR
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  • ADC45590.1
 172569 - 174362 (-) beta-glucuronidase precursor
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  • ADC45591.1
 174404 - 175621 (-) beta-glucosidase
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  • ADC45592.1
 175618 - 176493 (-) ABC transporter
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  • ADC45593.1
 176490 - 178325 (-) ABC transporter
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  • ADC45594.1
 178322 - 179278 (-) transporter
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  • ADC45595.1
 179275 - 180837 (-) extracellular solute-binding protein
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  • ADC45596.1
 181085 - 181693 (+) TetR-family transcriptional regulator
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  • ADC45597.1
 181698 - 182726 (-) LacI-family transcriptional regulator
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  • ADC45598.1
 182934 - 183905 (+) carbohydrate kinase
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  • ADC45599.1
 183922 - 184824 (+) hypothetical protein
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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