BGC0000100: monensin biosynthetic gene cluster from Streptomyces cinnamonensis
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Location: 1 - 103,450 nt. (total: 103,450 nt).
This entry is originally from NCBI GenBank AF440781.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000100
Short description monensin biosynthetic gene cluster from Streptomyces cinnamonensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AF440781.1
Compounds
  • monensin
Species Streptomyces cinnamonensis [taxonomy]
References
Chemical products information
monensin
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C36H62O11
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAO65782.1
  • gdhA
 1 - 1038 (-) glutamate dehydrogenase
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  • AAO65783.1
  • dapA
 1220 - 2140 (-) dihidro-dipicolinate synthase
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  • AAO65784.1
 2211 - 3152 (+) hypothetical DNA binding protein
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  • AAO65785.1
 3264 - 3680 (+) hypothetical protein
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  • AAO65786.1
 3684 - 4307 (-) hypothetical protein
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  • AAO65787.1
 4570 - 4758 (+) hypothetical protein
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  • AAO65788.1
 5058 - 5612 (+) hypothetical protein
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  • AAO65789.1
 5693 - 6010 (-) acyl carrier protein
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  • AAO65790.1
 6045 - 8531 (-) ketosynthase-like protein
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  • AAO65791.1
  • monCII
 8643 - 9542 (-) monensin cyclase
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  • AAO65792.1
  • monE
 9596 - 10426 (-) monensin 3-O-methyl transferase
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  • AAO65793.1
  • monT
 10656 - 12191 (+) putative monensin resistance protein
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  • AAO65794.1
  • monRII
 12205 - 12780 (+) putative monensin cluster negative regulator
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  • AAO65795.1
  • monAIX
 13023 - 13829 (-) PKS thioesterase
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  • AAO65796.1
  • monAI
 14121 - 23198 (+) monensin polyketide synthase loading module and module 1
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  • AAO65797.1
  • monAII
 23205 - 29921 (+) monensin polyketide synthase module 2
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  • AAO65798.1
  • monAIII
 29974 - 42372 (+) monensin polyketide synthase modules 3 and 4
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  • AAO65799.1
  • monAIV
 42448 - 54564 (+) monensin polyketide synthase modules 5 and 6
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  • AAO65800.1
  • monAV
 54614 - 66934 (+) monensin polyketide synthase modules 7 and 8
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  • AAO65801.1
  • monAVI
 66952 - 72054 (+) monensin polyketide synthase module 9
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  • AAO65802.1
  • monH
 72051 - 74993 (+) putative regulatory protein
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  • AAO65803.1
  • monC1
 75051 - 76541 (-) monensin epoxidase
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  • AAO65804.1
  • monBII
 76538 - 76960 (-) probable monensin biosynthesis isomerase
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  • AAO65805.1
  • monBI
 77016 - 77450 (-) probable monensin biosynthesis isomerase
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  • AAO65806.1
  • monAVIII
 77447 - 88708 (-) monensin polyketide synthase modules 11 and 12
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  • AAO65807.1
  • monAVII
 88816 - 93741 (-) monensin polyketide synthase module 10
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  • AAO65808.1
  • monD
 93981 - 95273 (+) monensin hydroxylase
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  • AAO65809.1
  • monRI
 95338 - 96141 (-) activator protein
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  • AAO65810.1
  • monAX
 96138 - 96941 (-) thioesterase
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  • AAO65811.1
 97580 - 98953 (+) unknown
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  • AAO65812.1
 98991 - 99983 (-) putative lipase
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  • AAO65813.1
 100507 - 101433 (-) hypothetical transport protein
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  • AAO65814.1
 101490 - 102581 (-) unknown
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  • AAO65815.1
  • amtA
 102924 - >103450 (+) glycine amidinotransferase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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