BGC0000106: naphthomycin A biosynthetic gene cluster from Streptomyces sp. CS
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Location: 1 - 106,181 nt. (total: 106,181 nt).
This entry is originally from NCBI GenBank GQ452266.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000106
Short description naphthomycin A biosynthetic gene cluster from Streptomyces sp. CS
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Ansamycin)
Loci NCBI GenBank: GQ452266.1
Compounds
  • naphthomycin A
Species Streptomyces sp. CS [taxonomy]
References
Chemical products information
naphthomycin A
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C40H46Cl1N1O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADM46349.1
 3 - 1730 (+) ATP/GTP-binding protein
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  • ADM46350.1
 1897 - 4032 (+) ATP/GTP-binding protein
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  • ADM46351.1
 4107 - 4250 (-) hypothetical protein
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  • ADM46352.1
 4714 - 5007 (-) protoporphyrinogen oxidase
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  • ADM46353.1
 6855 - 8072 (+) transcriptional regulator
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  • ADM46354.1
 8300 - 8935 (+) acyl carrier protein phosphodiesterase
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  • ADM46355.1
 9033 - 10226 (+) cytochrome P450-like protein
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  • ADM46356.1
  • natA
 10604 - 27700 (+) polyketide synthase
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  • ADM46357.1
  • natB
 27735 - 43754 (+) polyketide synthase
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  • ADM46358.1
  • natC
 43801 - 59766 (+) polyketide synthase
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  • ADM46359.1
  • natD
 59868 - 70733 (+) polyketide synthase
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  • ADM46360.1
  • natE
 70764 - 81365 (+) polyketide synthase
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  • ADM46361.1
  • natF
 81409 - 82278 (+) amide synthase
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  • ADM46362.1
  • nat1
 82335 - 83678 (+) halogenase
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  • ADM46363.1
  • natG
 83802 - 84863 (+) 3-dehydroquinate synthase
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  • ADM46364.1
  • natH
 84896 - 86332 (+) DAHP synthase
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  • ADM46365.1
  • natI
 86329 - 87174 (+) shikimate/quinate dehydrogenase
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  • ADM46366.1
  • natK
 87338 - 88498 (+) 3-amino-5-hydroxybenzoic acid synthase
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  • ADM46367.1
  • natL
 88495 - 89589 (+) oxidoreductase
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  • ADM46368.1
  • natM
 89597 - 90292 (+) phosphatase
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  • ADM46369.1
  • natN
 90295 - 91215 (+) glucose kinase
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  • ADM46370.1
  • nat2
 91304 - 93061 (-) FAD-dependent oxidoreductase
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  • ADM46371.1
  • natR
 93194 - 93967 (+) thioesterase
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  • ADM46372.1
  • nat4
 94001 - 95386 (+) membrane ion antiporter
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  • ADM46373.1
  • natJ
 95383 - 95823 (+) aminodehydroquinate dehydratase
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  • ADM46374.1
  • nat5
 95894 - 96586 (+) putative alpha/beta fold family protein
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  • ADM46375.1
  • nat6
 96664 - 97227 (+) activator of Hsp90 ATPase
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  • ADM46376.1
  • nat7
 97324 - 98754 (-) metallopeptidase
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  • ADM46377.1
  • nat8
 98931 - 99689 (+) gntr family transcriptional regulator
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  • ADM46378.1
  • nat9
 99954 - 101543 (+) amino-acid permease transmembrane protein
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  • ADM46379.1
  • nat10
 101969 - 102385 (+) hydrolase
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  • ADM46380.1
  • nat11
 103250 - 105862 (+) magnesium or manganese-dependent protein phosphatase
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Polyketide-specific information
Subclass Ansamycin
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Macrolactamization
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: HRPPCVKCIQDPTKAL4P4W6CV7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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