BGC0000110: spectinabilin biosynthetic gene cluster from Streptomyces orinoci
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 38,365 nt. (total: 38,365 nt).
This entry is originally from NCBI GenBank AM778535.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000110
Short description spectinabilin biosynthetic gene cluster from Streptomyces orinoci
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The AT domain within module 6 is inactive and thus module 6 uses the AT domain from module 5."
Biosynthetic class(es)
  • Polyketide (Polyene)
Loci NCBI GenBank: AM778535.1
Compounds
  • spectinabilin
  • orinocin
  • SNF4435C
  • SNF4435D
Species Streptomyces orinoci [taxonomy]
References
Chemical products information
spectinabilin
Copy SMILES
C28H31N1O6
Chemical database entries
NPAtlas
orinocin
Copy SMILES
C19H19N1O6
Chemical database entries
NPAtlas
SNF4435C
Copy SMILES
C28H31N1O6
Chemical database entries
NPAtlas
ChemSpider
SNF4435D
Copy SMILES
C28H31N1O6
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAO85889.1
  • norD
 1 - 390 (+) regulator protein NorD
copy AA seq
copy Nt seq
  • CAO85890.1
  • norE
 387 - 2237 (-) aryl-coA ligase
copy AA seq
copy Nt seq
  • CAO85891.1
  • norF
 2170 - 3186 (+) N-oxygenase
copy AA seq
copy Nt seq
  • CAO85892.1
  • norJ
 3223 - 4287 (+) NorJ protein
copy AA seq
copy Nt seq
  • CAO85893.1
  • norA
 4343 - 10036 (+) modular polyketide synthase NorA
copy AA seq
copy Nt seq
  • CAO85894.1
  • norG
 10047 - 12158 (+) PABA synthase
copy AA seq
copy Nt seq
  • CAO85895.1
  • norH
 12208 - 13428 (+) cytochrome P-450 monooxygenase
copy AA seq
copy Nt seq
  • CAO85896.1
  • norA_
 13478 - 24355 (+) protein modular polyketide synthase NorA'
copy AA seq
copy Nt seq
  • CAO85897.1
  • norB
 24342 - 30866 (+) modular polyketide synthase NorB
copy AA seq
copy Nt seq
  • CAO85898.1
  • norC
 30873 - 37673 (+) modular polyketide synthase NorC
copy AA seq
copy Nt seq
  • CAO85899.1
  • norI
 37673 - 38365 (+) methyltransferase NorI
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Polyene
Starter unit p-Nitrobenzoate
Cyclic? no
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
norA
+
norC
+
norB
+
norA_ 		Synthase subclass: Modular type I
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: norA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: norA_
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: norA_
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: norB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Methylmalonyl-CoA
Genes: norC
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 6
Genes: norC
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.