BGC0000120: patulin biosynthetic gene cluster from Penicillium expansum
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Location: 1 - 40,217 nt. (total: 40,217 nt).
This entry is originally from NCBI GenBank KF899892.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000120
Short description patulin biosynthetic gene cluster from Penicillium expansum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "The patulin genes cluster and its boudaries have been validated by the deletetion of patL (AIG62143), gene encoding the specific transcription factor (PMID: 26582186 ).\n\nThe patulin cluster has been described in A. clavatus (PMID:19383676)\n\nThe role of PatH (AIG62144) , PatI (AIG62145) and PatG (AIG62133) has been determined by heterologous expression studies (PMID:19383676 and PMID:24334092)\n\nThe role of PatE (AIG62134) has been determined by knock-out (27913847)."
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: KF899892.1
Compounds
  • patulin
Species Penicillium expansum [taxonomy]
References
Chemical products information
patulin [synonyms: Clavacin, Expansin, Clavatin, Claviform, Expansine, Patuline, Clairformin, Claviformin, Gigantin, Leucopin, Tercinin, Mycoin, Mycoine C3, Mycoin C3, Penicidin, Mycosin, Penatin, Terinin, Mycoin C, Sch-351633, Clavicin, Clavitin, Expansion]
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C7H6O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIG62144.1
  • patH
 195 - 2035 (-) M-cresol hydroxylase
  • Tailoring (Hydroxylation)
Heterologous expression
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  • AIG62133.1
  • patG
 2810 - 3834 (-) 6-methylsalicylic decarboxylase
  • Tailoring (Decarboxylation)
Heterologous expression
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  • AIG62137.1
  • patF
 4350 - 4949 (-) hypothetical protein
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  • AIG62134.1
  • patE
 5362 - 7362 (+) patulin synthase
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  • AIG62135.1
  • patD
 7640 - 9147 (-) hypothetical protein
  • Tailoring (Unknown)
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  • AIG62136.1
  • patC
 9636 - 11387 (-) MFS transporter
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  • AIG62138.1
  • patB
 12080 - 14006 (+) carboxylesterase family protein
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  • AIG62139.1
  • patA
 14650 - 15690 (-) acetate transporter
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  • AIG62140.1
  • patM
 16342 - 20894 (-) ABC transporter
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  • AIG62141.1
  • patN
 21354 - 22249 (+) isoepoxydon dehydrogenase
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  • AIG62142.1
  • patO
 22914 - 24873 (+) isoamyl alcohol oxidase
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  • AIG62143.1
  • patL
 26056 - 28511 (-) C6 transcription activator
  • Regulation
Knock-out
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  • AIG62145.1
  • patI
 30147 - 32032 (-) M-hydroxybenzyl alcohol hydroxylase
  • Tailoring (Hydroxylation)
Heterologous expression
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  • AIG62147.1
  • patJ
 32661 - 33776 (-) hypothetical protein
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  • AIG62146.1
  • patK
 34613 - 40016 (+) 6-methylsalicylic acid synthase
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
patK Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, C2-C7 first
Iteration counts: 3
Module 1
Specificity: Malonyl-CoA
Genes: patK
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Activity assay
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7M4BGWDEABIQBOJEBD7LO4YZ, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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