BGC0000130: pyrrolomycin A biosynthetic gene cluster from Streptomyces vitaminophilus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 55,655 nt. (total: 55,655 nt).
This entry is originally from NCBI GenBank EF140901.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000130
Short description pyrrolomycin A biosynthetic gene cluster from Streptomyces vitaminophilus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
EF140901.1
via
Compounds
  • pyrrolomycin A
  • pyrrolomycin B
  • pyrrolomycin C
  • pyrrolomycin D
Species Streptomyces vitaminophilus [taxonomy]
References
Chemical products information
pyrrolomycin A Evidence:
Copy SMILES
C4H2Cl2N2O2
pyrrolomycin B Evidence:
Copy SMILES
C11H6Cl4N2O3
Chemical database entries
PubCHEM
pyrrolomycin C Evidence:
Copy SMILES
C11H5Cl4N1O2
Chemical database entries
NPAtlas
pyrrolomycin D Evidence:
Copy SMILES
C11H4Cl5N1O2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABO15837.1
 1 - 843 (+) formate dehydrogenase
    copy AA seq
    copy Nt seq
    • ABO15838.1
    • pyr2
    		 892 - 2502 (-) FAD-dependent monooxygenase
      copy AA seq
      copy Nt seq
      • ABO15839.1
      • pyr3
      		 2579 - 3199 (-) TetR family regulator
        copy AA seq
        copy Nt seq
        • ABO15840.1
        • pyr4
        		 3490 - 5427 (+) 2-oxoglutarate ferredoxin oxidoreductase alpha subunit
          copy AA seq
          copy Nt seq
          • ABO15841.1
          • pyr5
          		 5513 - 6580 (+) 2-oxoglutarate ferredoxin oxidoreductase beta subunit
            copy AA seq
            copy Nt seq
            • ABO15842.1
            • pyr6
            		 6626 - 8065 (+) membrane antiporter
              copy AA seq
              copy Nt seq
              • ABO15843.1
              • pyr7
              		 8174 - 9313 (+) acyl-CoA dehydrogenase
                copy AA seq
                copy Nt seq
                • ABO15844.1
                • pyr8
                		 9376 - 10788 (+) amino acid adenyltransferase
                  copy AA seq
                  copy Nt seq
                  • ABO15845.1
                  • pyr9
                  		 10788 - 11351 (+) flavin reductase
                    copy AA seq
                    copy Nt seq
                    • ABO15846.1
                    • pyr10
                    		 11426 - 11725 (-) acyl-carrier protein
                      copy AA seq
                      copy Nt seq
                      • ABO15847.1
                      • pyr11
                      		 11887 - 13560 (-) halogenase
                        copy AA seq
                        copy Nt seq
                        • ABO15848.1
                        • pyr12
                        		 13733 - 14602 (-) hypothetical membrane protein
                          copy AA seq
                          copy Nt seq
                          • ABO15849.1
                          • pyr13
                          		 14861 - 15643 (-) oxidoreductase
                            copy AA seq
                            copy Nt seq
                            • ABO15850.1
                            • pyr14
                            		 16121 - 16639 (-) hypothetical protein
                              copy AA seq
                              copy Nt seq
                              • ABO15851.1
                              • pyr15
                              		 17291 - 18232 (+) oxidoreductase
                                copy AA seq
                                copy Nt seq
                                • ABO15852.1
                                • pyr16
                                		 18641 - 20395 (+) halogenase
                                  copy AA seq
                                  copy Nt seq
                                  • ABO15853.1
                                  • pyr17
                                  		 20429 - 22087 (+) halogenase
                                    copy AA seq
                                    copy Nt seq
                                    • ABO15854.1
                                    • pyr18
                                    		 22254 - 24338 (+) assimilatory nitrate reductase catalytic subunit
                                      copy AA seq
                                      copy Nt seq
                                      • ABO15855.1
                                      • pyr19
                                      		 24575 - 25996 (+) assimilatory nitrate reductase electron transfer subunit
                                        copy AA seq
                                        copy Nt seq
                                        • ABO15856.1
                                        • pyr20
                                        		 26400 - 27617 (+) cytochrome P450
                                          copy AA seq
                                          copy Nt seq
                                          • ABO15857.1
                                          • pyr21
                                          		 27983 - 28297 (+) monooxygenase
                                            copy AA seq
                                            copy Nt seq
                                            • ABO15858.1
                                            • pyr22
                                            		 28625 - 29323 (-) methyl transferase
                                              copy AA seq
                                              copy Nt seq
                                              • ABO15859.1
                                              • pyr23
                                              		 29608 - 30675 (-) putative membrane protein
                                                copy AA seq
                                                copy Nt seq
                                                • ABO15860.1
                                                • pyr24
                                                		 30893 - 37588 (-) polyketide synthase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • ABO15861.1
                                                  • pyr25
                                                  		 37591 - 44094 (-) polyketide synthase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • ABO15862.1
                                                    • pyr26
                                                    		 44146 - 45054 (+) thioesterase
                                                      copy AA seq
                                                      copy Nt seq
                                                      • ABO15863.1
                                                      • pyr27
                                                      		 45020 - 45643 (-) TetR family regulator
                                                        copy AA seq
                                                        copy Nt seq
                                                        • ABO15864.1
                                                        • pyr28
                                                        		 45992 - 46264 (+) proline carrier protein
                                                          copy AA seq
                                                          copy Nt seq
                                                          • ABO15865.1
                                                          • pyr29
                                                          		 46328 - 47671 (+) halogenase
                                                            copy AA seq
                                                            copy Nt seq
                                                            • ABO15866.1
                                                            • pyr30
                                                            		 47945 - 48838 (-) 4'-phosphopantetheinyl transferase
                                                              copy AA seq
                                                              copy Nt seq
                                                              • ABO15867.1
                                                              • pyr31
                                                              		 49044 - 50828 (-) acyl-CoA dehydrogenase
                                                                copy AA seq
                                                                copy Nt seq
                                                                • ABO15868.1
                                                                		 51057 - 52499 (+) homogentisate 1,2-dioxygenase
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • ABO15869.1
                                                                  		 52496 - 53248 (+) GntR-family regulator
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • ABO15870.1
                                                                    		 53341 - 54492 (+) acyl-CoA dehydrogenase
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • ABO15871.1
                                                                      		 54492 - 55655 (+) L-carnitine dehydratase
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        Biosynthesis information

                                                                        No biosynthesis information available for this record.

                                                                        Annotation changelog

                                                                        Entry version: 4

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-10-07
                                                                        Update chemical activity to schema version 2.11
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 3

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-09-15
                                                                        Updated bioactivity data
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 2

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2019-10-16
                                                                        Migrated from v1.4
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2019-10-16
                                                                        Updated compound(s) information (NPAtlas curation)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 1

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2015-06-12
                                                                        Submitted
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        Similar known clusters from MIBiG 4.0
                                                                        Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                        Detailed help and explanations are available here.

                                                                        Click on reference genes to show details of similarities to genes within the current region.
                                                                        Double click on a reference drawing to reverse the display of the genes.

                                                                        Click on an accession to open that entry in the MIBiG database.


                                                                        Location:

                                                                        Identifier
                                                                        Identity
                                                                        Coverage
                                                                        Detailed domain annotation
                                                                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                        A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                        Selected features only
                                                                        Show module domains