BGC0000145: salinosporamide A biosynthetic gene cluster from Salinispora tropica
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Location: 1 - 32,637 nt. (total: 32,637 nt).
This entry is originally from NCBI GenBank EF397502.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000145
Short description salinosporamide A biosynthetic gene cluster from Salinispora tropica
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
EF397502.1
via Knock-out studies
Compounds
  • salinosporamide A
Species Salinispora tropica [taxonomy]
References
Chemical products information
salinosporamide A Evidence:
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C15H20Cl1N1O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABP73634.1
  • salU
 2 - 307 (+) SalU
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    • ABP73635.1
    • salT
    		 355 - 1158 (+) SalT
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      • ABP73636.1
      • salS
      		 1364 - 1819 (+) SalS
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        • ABP73637.1
        • salRIII
        		 2926 - 3948 (+) SalRIII
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          • ABP73638.1
          • salQ
          		 4754 - 8203 (-) SalQ
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            • ABP73639.1
            • salRII
            		 8587 - 9264 (+) SalRII
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              • ABP73640.1
              • salO
              		 9296 - 10129 (-) SalO
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                • ABP73641.1
                • salN
                		 10134 - 10913 (-) SalN
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                  • ABP73642.1
                  • salM
                  		 11151 - 11918 (+) SalM
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                    • ABP73643.1
                    • salL
                    		 12058 - 12909 (+) SalL
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                      • ABP73644.1
                      • salK
                      		 13250 - 14095 (-) SalK
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                        • ABP73645.1
                        • salA
                        		 14478 - 20639 (+) SalA
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                          • ABP73646.1
                          • salB
                          		 20636 - 22534 (+) SalB
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                            • ABP73647.1
                            • salC
                            		 22531 - 24324 (+) SalC
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                              • ABP73648.1
                              • salD
                              		 24345 - 25598 (+) SalD
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                                • ABP73649.1
                                • salE
                                		 25604 - 25819 (+) SalE
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                                  • ABP73650.1
                                  • salF
                                  		 25819 - 26679 (+) SalF
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                                    • ABP73651.1
                                    • salG
                                    		 26667 - 28049 (+) SalG
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                                      • ABP73652.1
                                      • salH
                                      		 28033 - 29811 (+) SalH
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                                        • ABP73653.1
                                        • salI
                                        		 30256 - 31092 (-) SalI
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                                          • ABP73654.1
                                          • salJ
                                          		 32338 - >32637 (+) SalJ
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                                            Biosynthesis information

                                            Biosynthetic modules

                                            Name
                                            Unk01
                                            Type
                                            nrps-type1
                                            Genes
                                            salB
                                            Substrates
                                            3S-cyclohex-2-enylalanine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Annotation changelog

                                            Entry version: 4

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Added missing NRP class
                                            • (ID: CUSGWVK3I4TVHJH7NHPFAP2L)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Updated bioactivity data
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Added NRP substrate specificities
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2019-10-16
                                            Updated compound(s) information (NPAtlas curation)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2015-06-12
                                            Submitted
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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