BGC0000150: sporolide A biosynthetic gene cluster from Salinispora tropica CNB-440
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Location: 3,027,087 - 3,086,780 nt. (total: 59,694 nt).
This entry is originally from NCBI GenBank CP000667.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000150
Short description sporolide A biosynthetic gene cluster from Salinispora tropica CNB-440
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Enediyne type I)
Loci
CP000667.1
3027087 - 3086780
via Enzymatic assays
Compounds
  • sporolide A
  • sporolide B
Species Salinispora tropica CNB-440 [taxonomy]
References
Chemical products information
sporolide A Evidence:
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C24H23Cl1O12
sporolide B Evidence:
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C24H23Cl1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Strop_2691
  • ABP55135.1
 3027087 - 3027416 (-) hypothetical protein
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    • Strop_2692
    • ABP55136.1
    		 3027520 - 3028152 (-) transcriptional regulator
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      • Strop_2693
      • ABP55137.1
      		 3028644 - 3029429 (+) transcriptional regulator, AraC family
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        • Strop_2694
        • ABP55138.1
        		 3029601 - 3030959 (-) cytochrome P450
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          • Strop_2695
          • ABP55139.1
          		 3030956 - 3031492 (-) flavin reductase domain protein, FMN-binding
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            • Strop_2696
            • ABP55140.1
            		 3031492 - 3031956 (-) hypothetical protein
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              • Strop_2697
              • ABP55141.1
              		 3031962 - 3037733 (-) beta-ketoacyl synthase
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                • Strop_2698
                • ABP55142.1
                		 3037730 - 3038716 (-) hypothetical protein
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                  • Strop_2699
                  • ABP55143.1
                  		 3038722 - 3040689 (-) ASPIC/UnbV domain protein
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                    • Strop_2700
                    • ABP55144.1
                    		 3040693 - 3041691 (-) protein of unknown function DUF1702
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                      • Strop_2701
                      • ABP55145.1
                      		 3041874 - 3042851 (-) protein of unknown function DUF1702
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                        • Strop_2702
                        • ABP55146.1
                        		 3043140 - 3044204 (+) NAD-dependent epimerase/dehydratase
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                          • Strop_2703
                          • ABP55147.1
                          		 3044128 - 3045210 (-) alkylhydroperoxidase like protein, AhpD family
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                            • Strop_2704
                            • ABP55148.1
                            		 3045293 - 3046945 (-) glucose-methanol-choline oxidoreductase
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                              • Strop_2705
                              • ABP55149.1
                              		 3046942 - 3047505 (-) hypothetical protein
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                                • Strop_2706
                                • ABP55150.1
                                		 3047931 - 3048851 (+) Wyosine base formation
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                                  • Strop_2707
                                  • ABP55151.1
                                  		 3049000 - 3049611 (+) hypothetical protein
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                                    • Strop_2708
                                    • ABP55152.1
                                    		 3049948 - 3051120 (+) Acyl-CoA dehydrogenase, type 2, C-terminal domain
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                                      • Strop_2709
                                      • ABP55153.1
                                      		 3051279 - 3051698 (+) hypothetical protein
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                                        • Strop_2710
                                        • ABP55154.1
                                        		 3051728 - 3053107 (+) monooxygenase, FAD-binding
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                                          • Strop_2711
                                          • ABP55155.1
                                          		 3053122 - 3054279 (+) Epoxide hydrolase domain protein
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                                            • Strop_2712
                                            • ABP55156.1
                                            		 3054480 - 3055646 (+) luciferase family protein
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                                              • Strop_2713
                                              • ABP55157.1
                                              		 3055726 - 3057276 (+) 4-hydroxyphenylacetate 3-hydroxylase
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                                                • Strop_2714
                                                • ABP55158.1
                                                		 3057393 - 3058703 (-) Sigma-70, region 4 type 2
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                                                  • Strop_2715
                                                  • ABP55159.1
                                                  		 3058700 - 3059080 (-) DGPFAETKE family protein
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                                                    • Strop_2716
                                                    • ABP55160.1
                                                    		 3059835 - 3060125 (+) hypothetical protein
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                                                      • Strop_2717
                                                      • ABP55161.1
                                                      		 3060126 - 3061049 (+) hypothetical protein
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                                                        • Strop_2718
                                                        • ABP55162.1
                                                        		 3061524 - 3063110 (-) major facilitator superfamily MFS_1
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                                                          • Strop_2719
                                                          • ABP55163.1
                                                          		 3063558 - 3063917 (+) DGPFAETKE family protein
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                                                            • Strop_2720
                                                            • ABP55164.1
                                                            		 3064097 - 3065341 (-) Acyl-CoA dehydrogenase, type 2, C-terminal domain
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                                                              • Strop_2721
                                                              • ABP55165.1
                                                              		 3065529 - 3066860 (+) condensation domain protein
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                                                                • Strop_2722
                                                                • ABP55166.1
                                                                		 3066965 - 3068305 (-) hypothetical protein
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                                                                  • Strop_2723
                                                                  • ABP55167.1
                                                                  		 3068318 - 3069334 (-) Alcohol dehydrogenase GroES domain protein
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                                                                    • Strop_2724
                                                                    • ABP55168.1
                                                                    		 3069331 - 3070560 (-) cytochrome P450
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                                                                      • Strop_2725
                                                                      • ABP55169.1
                                                                      		 3070970 - 3072736 (+) amino acid adenylation domain
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                                                                        • Strop_2726
                                                                        • ABP55170.1
                                                                        		 3072733 - 3072942 (+) MbtH domain protein
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                                                                          • Strop_2727
                                                                          • ABP55171.1
                                                                          		 3072970 - 3074046 (+) 4-hydroxyphenylpyruvate dioxygenase
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                                                                            • Strop_2728
                                                                            • ABP55172.1
                                                                            		 3074043 - 3074945 (+) hypothetical protein
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                                                                              • Strop_2729
                                                                              • ABP55173.1
                                                                              		 3075278 - 3075574 (+) hypothetical protein
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                                                                                • Strop_2730
                                                                                • ABP55174.1
                                                                                		 3075612 - 3076169 (+) hypothetical protein
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                                                                                  • Strop_2731
                                                                                  • ABP55175.1
                                                                                  		 3076625 - 3078043 (-) FAD linked oxidase domain protein
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                                                                                    • Strop_2732
                                                                                    • ABP55176.1
                                                                                    		 3078123 - 3079193 (+) hypothetical protein
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                                                                                      • Strop_2733
                                                                                      • ABP55177.1
                                                                                      		 3079206 - 3080726 (+) Methyltransferase type 11
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                                                                                        • Strop_2734
                                                                                        • ABP55178.1
                                                                                        		 3080799 - 3081056 (+) hypothetical protein
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                                                                                          • Strop_2735
                                                                                          • ABP55179.1
                                                                                          		 3081183 - 3082628 (-) major facilitator superfamily MFS_1
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                                                                                            • Strop_2736
                                                                                            • ABP55180.1
                                                                                            		 3082666 - 3083334 (-) protein of unknown function DUF899, thioredoxin family protein
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                                                                                              • Strop_2737
                                                                                              • ABP55181.1
                                                                                              		 3083472 - 3086780 (+) transcriptional activator domain
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                                                                                                Biosynthesis information

                                                                                                Biosynthetic modules

                                                                                                Name
                                                                                                1
                                                                                                Type
                                                                                                pks-modular
                                                                                                Genes
                                                                                                Strop_2697
                                                                                                Substrates
                                                                                                Integrated Monomers
                                                                                                Domains
                                                                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase
                                                                                                Annotation changelog

                                                                                                Entry version: 3

                                                                                                Date
                                                                                                Changes
                                                                                                Submitters
                                                                                                Reviewers
                                                                                                2022-09-15
                                                                                                Corrected NRP module activity
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                2022-09-15
                                                                                                Corrected gene identifiers
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                Entry version: 2

                                                                                                Date
                                                                                                Changes
                                                                                                Submitters
                                                                                                Reviewers
                                                                                                2019-10-16
                                                                                                Migrated from v1.4
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                2019-10-16
                                                                                                Updated compound(s) information (NPAtlas curation)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                Entry version: 1

                                                                                                Date
                                                                                                Changes
                                                                                                Submitters
                                                                                                Reviewers
                                                                                                2015-06-12
                                                                                                Submitted
                                                                                                • (ID: FGOE6VD55GZRETNYSNOKUJZO)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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