BGC0000153: stigmatellin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
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Location: 1 - 66,808 nt. (total: 66,808 nt).
This entry is originally from NCBI GenBank AJ421825.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000153
Short description stigmatellin biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AJ421825.1
via Knock-out studies
Compounds
  • stigmatellin
Species Stigmatella aurantiaca Sg a15 [taxonomy]
References
Chemical products information
stigmatellin Evidence:
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C30H42O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAD19077.1
 4978 - 6231 (-) cytochrome P450 monooxygenase
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    • CAD19078.1
    		 6369 - 7730 (+) protein kinase
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      • CAD19079.1
      		 7849 - 8577 (-) methyl transferase
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        • CAD19080.1
        		 8622 - 8879 (-) acyl-CoA binding protein
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          • CAD19081.1
          		 8961 - 10070 (+) potassium channel beta chain
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            • CAD19082.1
            		 10428 - 10862 (+) ribosome binding factor
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              • CAD19083.1
              		 10859 - 12016 (+)
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                • CAD19084.1
                		 12082 - 13974 (-) cellulase
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                  • CAD19085.1
                  • stiA
                  		 14345 - 21466 (+) StiA protein
                  • Scaffold biosynthesis
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                  • CAD19086.1
                  • stiB
                  		 21463 - 26220 (+) StiB protein
                  • Scaffold biosynthesis
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                  • CAD19087.1
                  • stiC
                  		 26284 - 31941 (+) StiC protein
                  • Scaffold biosynthesis
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                  • CAD19088.1
                  • stiD
                  		 31943 - 37738 (+) StiD protein
                  • Scaffold biosynthesis
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                  • CAD19089.1
                  • stiE
                  		 37740 - 43553 (+) StiE protein
                  • Scaffold biosynthesis
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                  • CAD19090.1
                  • stiF
                  		 43546 - 50202 (+) StiF protein
                  • Scaffold biosynthesis
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                  • CAD19091.1
                  • stiG
                  		 50205 - 54401 (+) StiG protein
                  • Scaffold biosynthesis
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                  • CAD19092.1
                  • stiH
                  		 54398 - 59212 (+) StiH protein
                  • Scaffold biosynthesis
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                  • CAD19093.1
                  • stiJ
                  		 59223 - 63002 (+) StiJ protein
                  • Scaffold biosynthesis
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                  • CAD19094.1
                  • stiK
                  		 63070 - 63840 (+) methyl transferase
                  • Tailoring
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                  • CAD19095.1
                  • stiL
                  		 63899 - 65470 (+) cytochrome P450 dependent monooxygenase
                  • Tailoring
                  • Knock-out
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                  • CAD19096.1
                  		 65537 - 66808 (+) polynucleotide adenyltransferase
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    1
                    Type
                    pks-modular
                    Genes
                    stiA
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                    Name
                    2
                    Type
                    pks-modular
                    Genes
                    stiB
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                    Name
                    3
                    Type
                    pks-modular
                    Genes
                    stiC
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                    Name
                    4
                    Type
                    pks-modular
                    Genes
                    stiD
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, methyltransferase, carrier (ACP)
                    Name
                    5
                    Type
                    pks-modular
                    Genes
                    stiD
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, methyltransferase, carrier (ACP)
                    Name
                    6
                    Type
                    pks-modular
                    Genes
                    stiE
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                    Name
                    7
                    Type
                    pks-modular
                    Genes
                    stiF
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
                    Name
                    8
                    Type
                    pks-modular
                    Genes
                    stiG
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                    Name
                    9
                    Type
                    pks-modular
                    Genes
                    stiH
                    Substrates
                    Integrated Monomers
                    Domains
                    acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Fixed incorrect gene identifiers
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2019-10-16
                    Updated compound(s) information (NPAtlas curation)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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