BGC0000158: tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 78,527 nt. (total: 78,527 nt).
This entry is originally from NCBI GenBank EU035755.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000158
Short description tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: EU035755.1
Compounds
  • tautomycetin
Species Streptomyces griseochromogenes [taxonomy]
References
Chemical products information
tautomycetin
Copy SMILES
C33H50O10
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABV91285.1
 449 - 1237 (+) probable transposase
copy AA seq
copy Nt seq
  • ABV91302.1
  • ttnQ
 1777 - 3195 (-) regulator
  • Regulation
Knock-out
copy AA seq
copy Nt seq
  • ABV91295.1
  • ttnJ
 3490 - 5172 (-) putative multidrug transporter
copy AA seq
copy Nt seq
  • ABV91294.1
  • ttnI
 5176 - 6525 (-) cytochrome P450
  • Tailoring (Oxidation)
Knock-out
copy AA seq
copy Nt seq
  • ABV91303.1
  • ttnR
 6522 - 7934 (-) MmgE/PrpD family protein
  • Tailoring (Dehydration)
Knock-out
copy AA seq
copy Nt seq
  • ABV91304.1
  • ttnS
 7931 - 8743 (-) putative cyclase
  • Unknown
Knock-out
copy AA seq
copy Nt seq
  • ABV91293.1
  • ttnH
 8774 - 9553 (-) probable thioesterase
copy AA seq
copy Nt seq
  • ABV91292.1
  • ttnG
 9973 - 12753 (+) putative transcriptional regulator
copy AA seq
copy Nt seq
  • ABV91291.1
  • ttnF
 12770 - 14287 (+) dehydratase
  • Tailoring (Dehydration)
Knock-out
copy AA seq
copy Nt seq
  • ABV91290.1
  • ttnE
 15238 - 16572 (-) predicted crotonyl-CoA reductase
copy AA seq
copy Nt seq
  • ABV91289.1
  • ttnD
 16600 - 18057 (-) decarboxylase
  • Tailoring (Decarboxylation)
Knock-out
copy AA seq
copy Nt seq
  • ABV91288.1
  • ttnC
 18054 - 18683 (-) decarboxylase
  • Tailoring (Unknown)
Knock-out
copy AA seq
copy Nt seq
  • ABV91287.1
  • ttnB
 18689 - 41419 (-) type I modular polyketide synthase
copy AA seq
copy Nt seq
  • ABV91286.1
  • ttnA
 41439 - 70025 (-) type I modular polyketide synthase
  • Scaffold biosynthesis
Knock-out
copy AA seq
copy Nt seq
  • ABV91296.1
  • ttnK
 70295 - 71692 (+) putative type B carboxylesterase
copy AA seq
copy Nt seq
  • ABV91301.1
  • ttnP
 71711 - 72862 (+) acyl-CoA transferases
  • Precursor biosynthesis
Knock-out
copy AA seq
copy Nt seq
  • ABV91300.1
  • ttnO
 72859 - 73788 (+) probable citrate lyase beta subunit
copy AA seq
copy Nt seq
  • ABV91299.1
  • ttnN
 73785 - 74876 (+) conserved hypothetical protein
copy AA seq
copy Nt seq
  • ABV91298.1
  • ttnM
 74920 - 75939 (+) predicted hydroxylase
  • Tailoring (Hydroxylation)
Knock-out
copy AA seq
copy Nt seq
  • ABV91297.1
  • ttnL
 76039 - 76596 (+) conserved hypothetical protein
copy AA seq
copy Nt seq
  • ABV91284.1
 76744 - 78267 (+) putative glycosyl transferase
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
ttnB
+
ttnA 		Synthase subclass: Modular type I
Module 0
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnA
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnB
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnB
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 8
Specificity: Ethylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnB
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 9
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ttnB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP), Thioesterase
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: E2T2HCM4X7QXVS4LL4JVBPPK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.