BGC0000177: iso-migrastatin biosynthetic gene cluster from Streptomyces platensis subsp. rosaceus
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Location: 1 - 53,336 nt. (total: 53,336 nt).
This entry is originally from NCBI GenBank GQ274953.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000177
Short description iso-migrastatin biosynthetic gene cluster from Streptomyces platensis subsp. rosaceus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolide)
Loci NCBI GenBank: GQ274953.1
Compounds
  • iso-migrastatin
  • migrastatin
  • dorrigocin A
  • dorrigocin B
  • 13-epi-dorrigocin A
Species Streptomyces platensis subsp. rosaceus [taxonomy]
References
Chemical products information
iso-migrastatin [synonyms: iso-mgs]
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C27H39N1O7
Chemical database entries
NPAtlas
PubCHEM
ChEMBL
migrastatin [synonyms: mgs]
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C27H39N1O7
Chemical database entries
NPAtlas
PubCHEM
dorrigocin A
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C27H41N1O8
Chemical database entries
NPAtlas
PubCHEM
dorrigocin B
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C27H41N1O8
Chemical database entries
NPAtlas
PubCHEM
13-epi-dorrigocin A
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C27H41N1O8
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACY01386.1
 1 - 3654 (-) transcriptional regulator
  • Regulation
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  • ACY01387.1
 4026 - 5615 (+) trans-acting acyl transferase/thioesterase fusion protein
  • Scaffold biosynthesis
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  • ACY01388.1
 5701 - 5952 (+) acyl carrier protein
  • Scaffold biosynthesis
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  • ACY01389.1
 5957 - 7927 (+) amidotransferase
  • Tailoring (Amination)
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  • ACY01390.1
 7943 - 17521 (+) AT-less polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ACY01391.1
 17568 - 41648 (+) AT-less polyketide synthase
  • Scaffold biosynthesis
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  • ACY01392.1
 41705 - 47566 (+) AT-less polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ACY01393.1
 47568 - 49823 (+) trans-acting acyl transferase/oxidoreductase fusion protein
  • Scaffold biosynthesis
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  • ACY01394.1
 49855 - 50871 (+) oxidoreductase
  • Tailoring (Reduction)
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  • ACY01395.1
 51167 - 52012 (+) O-methyl transferase
  • Tailoring (Methylation)
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  • ACY01396.1
 52125 - 53336 (+) hydroxylase
  • Tailoring (Hydroxylation)
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Polyketide-specific information
Subclass Macrolide
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
ACY01392.1
+
ACY01390.1
+
ACY01391.1
+
ACY01388.1
+
ACY01393.1 		Synthase subclass: Modular type I/Trans-AT type I
Trans-acyltansferases: ACY01393.1
Module 0
Genes: ACY01388.1
Core domains: Thiolation (ACP/PCP)
Module 1
Genes: ACY01390.1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Genes: ACY01390.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Michael branching
Module 3
Genes: ACY01390.1, ACY01391.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Genes: ACY01391.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 5
Genes: ACY01391.1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 6
Genes: ACY01391.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 7
Genes: ACY01391.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 8
Genes: ACY01391.1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 9
Genes: ACY01391.1, ACY01392.1
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 10
Genes: ACY01392.1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: HPZ6LL7T2WJIC44FKRYGWFQ6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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