BGC0000181: macrolactin H biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 1 - 54,840 nt. (total: 54,840 nt).
This entry is originally from NCBI GenBank AJ634061.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000181
Short description macrolactin H biosynthetic gene cluster from Bacillus velezensis FZB42
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AJ634061.2
Compounds
  • macrolactin H
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
macrolactin H
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C24H34O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG23963.1
  • pks2A
 1 - 2307 (+) malonyl CoA [acyl-carrier-protein] transacylase
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  • CAG23964.1
  • pks2B
 2329 - 14589 (+) polyketide synthase type I
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  • CAG23965.1
  • pks2C
 14589 - 19361 (+) polyketide synthase type I
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  • CAG23966.1
  • pks2D
 19379 - 28117 (+) polyketide synthase type I
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  • CAG23967.1
  • pks2E
 28110 - 35114 (+) polyketide synthase type I
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  • CAG23968.1
  • pks2F
 35129 - 40849 (+) polyketide synthase type I
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  • CAG23969.1
  • pks2G
 40846 - 48228 (+) polyketide synthase type I
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  • CAG23970.2
  • pks2H
 48267 - 52130 (+) polyketide synthase type I
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  • CAJ57404.1
  • pks2I
 52127 - 53254 (+) pbp related beta-lactamase precursor
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  • CAJ57405.1
  • pdhA
 53725 - 54840 (+) pyruvate dehydrogenase (E1 alpha subunit)
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
pks2A
+
pks2E
+
pks2H
+
pks2B
+
pks2F
+
pks2C
+
pks2D
+
pks2G 		Synthase subclass:
Module 0
Genes: pks2A
Core domains: Acyltransferase
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 1
Genes: pks2B
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Genes: pks2B
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Genes: pks2B, pks2C
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Genes: pks2C, pks2D
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Genes: pks2D
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Genes: pks2D, pks2E
Core domains: Ketosynthase, Thiolation (ACP/PCP), Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Genes: pks2E
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 8
Genes: pks2E, pks2F
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP), Ketoreductase
KR-domain stereochemistry: Unknown
Module 9
Genes: pks2F, pks2G
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Genes: pks2G
Core domains: Ketosynthase, Thiolation (ACP/PCP), Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 11
Genes: pks2G, pks2H
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP), Thiolation (ACP/PCP), Ketoreductase, Thioesterase
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FICEQDRJCNKWHHGNCRVDDP5D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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