BGC0000182: pseudomonic acid A biosynthetic gene cluster from Pseudomonas fluorescens
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 75,137 nt. (total: 75,137 nt).
This entry is originally from NCBI GenBank AF318063.3.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000182
Short description pseudomonic acid A biosynthetic gene cluster from Pseudomonas fluorescens
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: AF318063.3
Compounds
  • pseudomonic acid A
Species Pseudomonas fluorescens [taxonomy]
References
Chemical products information
pseudomonic acid A [synonyms: mupirocin]
Copy SMILES
C26H44O9
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFD33556.1
  • mupZ
 201 - 569 (+) MupZ
copy AA seq
copy Nt seq
  • AAK28503.1
  • mupA
 600 - 1709 (+) MupA
copy AA seq
copy Nt seq
  • AAM12909.2
  • mmpA
 1706 - 10243 (+) MmpA
copy AA seq
copy Nt seq
  • AAM12910.1
  • mupB
 10278 - 11183 (+) MupB
copy AA seq
copy Nt seq
  • AAM12911.1
  • mmpB
 11325 - 17555 (+) MmpB
copy AA seq
copy Nt seq
  • AAM12912.1
  • mmpC
 17629 - 20961 (+) MmpC
copy AA seq
copy Nt seq
  • AAM12913.2
  • mmpD
 20958 - 40526 (+) MmpD
copy AA seq
copy Nt seq
  • AAM12914.1
  • mupC
 40523 - 41818 (+) MupC
copy AA seq
copy Nt seq
  • AAM12915.1
  • macpA
 41870 - 42175 (+) MacpA
copy AA seq
copy Nt seq
  • AAM12916.1
  • mupD
 42216 - 42959 (+) MupD
copy AA seq
copy Nt seq
  • AAM12917.1
  • mupE
 42983 - 44005 (+) MupE
copy AA seq
copy Nt seq
  • AAM12918.1
  • macpB
 44062 - 44313 (+) MacpB
copy AA seq
copy Nt seq
  • AAM12919.1
  • mupF
 44334 - 45344 (-) MupF
copy AA seq
copy Nt seq
  • AAM12920.1
  • macpC
 45506 - 45742 (+) MacpC
copy AA seq
copy Nt seq
  • AAM12921.1
  • mupG
 45729 - 46967 (+) MupG
copy AA seq
copy Nt seq
  • AAM12922.1
  • mupH
 46964 - 48229 (+) MupH
copy AA seq
copy Nt seq
  • AAM12923.1
  • mupJ
 48226 - 48993 (+) MupJ
copy AA seq
copy Nt seq
  • AAM12924.1
  • mupK
 49047 - 49790 (+) MupK
copy AA seq
copy Nt seq
  • AAM12925.2
  • mmpE
 49802 - 53377 (+) MmpE
copy AA seq
copy Nt seq
  • AAM12926.1
  • mupL
 53423 - 54361 (+) MupL
copy AA seq
copy Nt seq
  • AAM12927.2
  • mupM
 54444 - 57536 (+) MupM
copy AA seq
copy Nt seq
  • AAM12928.2
  • mupN
 57597 - 58448 (+) MupN
copy AA seq
copy Nt seq
  • AAM12929.2
  • mupO
 58574 - 59938 (+) MupO
copy AA seq
copy Nt seq
  • AAM12930.2
  • mupP
 59935 - 60864 (+) MupP
copy AA seq
copy Nt seq
  • AAM12931.1
  • mupQ
 60912 - 62267 (+) MupQ
copy AA seq
copy Nt seq
  • AAM12932.1
  • mupS
 62264 - 63037 (+) MupS
copy AA seq
copy Nt seq
  • AAM12933.1
  • macpD
 63031 - 63351 (+) MacpD
copy AA seq
copy Nt seq
  • AAM12934.1
  • mmpF
 63348 - 65585 (+) MmpF
copy AA seq
copy Nt seq
  • AAM12935.1
  • macpE
 65730 - 65972 (+) MacpE
copy AA seq
copy Nt seq
  • AAM12936.1
  • mupT
 65995 - 66345 (+) MupT
copy AA seq
copy Nt seq
  • AAM12937.1
  • mupU
 66415 - 67992 (+) MupU
copy AA seq
copy Nt seq
  • AAM12938.1
  • mupV
 68027 - 70015 (+) MupV
copy AA seq
copy Nt seq
  • AAM12939.1
  • mupW
 70055 - 71446 (+) MupW
copy AA seq
copy Nt seq
  • AAK28504.1
  • mupR
 71638 - 72342 (+) MupR
copy AA seq
copy Nt seq
  • AAM12940.1
  • mupX
 72380 - 73918 (+) MupX
copy AA seq
copy Nt seq
  • AAK28505.1
  • mupI
 73911 - 74486 (-) MupI
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
mmpB
+
mmpA
+
mmpD 		Synthase subclass: Iterative type I/Trans-AT type I
Trans-acyltansferases: mmpC
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 3
Module 1
Genes: mmpD
Core domains: Ketosynthase, Dehydratase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 2
Genes: mmpD
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Genes: mmpD
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 4
Genes: mmpD
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Genes: mmpA
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 6
Genes: mmpA
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Genes: mmpA
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Scaffold-modifying domains: Beta-branching
Module 8
Genes: mmpB
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP), Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: E74IDV7HCE4GDGQ2TWFM7I3H, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed entry error in polyketide synthase gene list
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
  • Fix trans_at gene ID
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.