BGC0000199: arimetamycin B biosynthetic gene cluster from uncultured bacterium
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Location: 1 - 40,894 nt. (total: 40,894 nt).
This entry is originally from NCBI GenBank KF040454.1.

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core biosynthetic genes
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000199
Short description arimetamycin B biosynthetic gene cluster from uncultured bacterium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Tetracycline)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: KF040454.1
Compounds
  • arimetamycin B
  • arimetamycin C
  • arimetamycin A
Species uncultured bacterium [taxonomy]
References
Chemical products information
arimetamycin B
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C27H28O12
Chemical database entries
NPAtlas
arimetamycin C
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C28H30O12
arimetamycin A
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C39H52N2O13
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHA81971.1
 1 - 781 (-) putative hydroxylase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • AHA82007.1
  • arm1
 884 - 1561 (-) O-methyl transferase
  • Tailoring (Demethylation)
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  • AHA81972.1
  • arm2
 1554 - 2483 (-) Aromatase
  • Scaffold biosynthesis
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  • AHA81973.1
  • arm3
 2591 - 3370 (-) Cyclase
  • Scaffold biosynthesis
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  • AHA81974.1
  • arm4
 3553 - 3993 (+) Cyclase
  • Scaffold biosynthesis
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  • AHA81975.1
  • arm5
 4035 - 4802 (+) Ketoreductase
  • Scaffold biosynthesis
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  • AHA81976.1
  • arm6
 4869 - 5210 (+) Monooygenase
  • Tailoring (Monooxygenation)
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  • AHA81977.1
  • arm7
 5243 - 6511 (+) KSα
  • Scaffold biosynthesis
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  • AHA81978.1
  • arm8
 6508 - 7731 (+) KSβ (CLF)
  • Scaffold biosynthesis
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  • AHA81979.1
  • arm9
 7747 - 8004 (+) ACP
  • Scaffold biosynthesis
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  • AHA81980.1
  • arm10
 8457 - 9212 (+) SARP family transcriptional regulator
  • Regulation
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  • AHA81981.1
  • arm11
 9461 - 10612 (+) P450-oxidoreductase
  • Tailoring (Unknown)
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  • AHA81982.1
  • arm12
 10674 - 11924 (+) Glycosyltransferase
  • Scaffold biosynthesis
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  • AHA81983.1
  • arm13
 11953 - 12282 (+) Unknown
  • Unknown
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  • AHA81984.1
  • arm14
 12279 - 13454 (+) O-methyltransferase
  • Tailoring (Demethylation)
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  • AHA81985.1
  • arm15
 13473 - 14639 (+) Oxygenase
  • Tailoring (Monooxygenation)
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  • AHA81986.1
  • arm16
 14716 - 16263 (-) Dehydrogenase
  • Tailoring (Oxidation)
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  • AHA81987.1
  • arm17
 16260 - 17456 (-) P450-oxidoreductase
  • Tailoring (Unknown)
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  • AHA81988.1
  • arm19
 18104 - 20044 (+) MarR family transcriptional regulator
  • Regulation
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  • AHA81989.1
  • arm20
 20041 - 20604 (+) Unknown
  • Unknown
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  • AHA81990.1
  • arm21
 20618 - 23404 (-) Unknown
  • Unknown
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  • AHA81991.1
  • arm22
 23624 - 24763 (+) NDP-hexose-C3-methyltransferase
  • Tailoring (Glycosylation)
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  • AHA81992.1
  • arm23
 24783 - 25757 (-) NDP-4-keto-6-deoxyhexose reductase
  • Tailoring (Glycosylation)
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  • AHA81993.1
  • arm24
 25948 - 27111 (+) NDP-hexose-3-aminotransferase
  • Tailoring (Glycosylation)
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  • AHA81994.1
  • arm25
 27147 - 28430 (+) Glycosyltransferase
  • Scaffold biosynthesis
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  • AHA81995.1
  • arm26
 28503 - 29354 (-) ABC transporter
  • Transport
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  • AHA81996.1
  • arm27
 29351 - 30412 (-) ANC transporter A TP-binding protein
  • Transport
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  • AHA81997.1
  • arm28
 30529 - 31518 (-) NDP-hexose-3-ketoreductase
  • Tailoring (Glycosylation)
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  • AHA81998.1
  • arm29
 31717 - 32871 (+) NDP-hexose-4-aminotransferase
  • Tailoring (Glycosylation)
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  • AHA81999.1
  • arm30
 32891 - 33655 (+) NDP-hexose-N,N-dimethyltransferase
  • Tailoring (Glycosylation)
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  • AHA82000.1
  • arm31
 33652 - 34878 (+) NDP-hexose-C3-methyltransferase
  • Tailoring (Glycosylation)
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  • AHA82001.1
  • arm32
 34868 - 36043 (+) P450-oxidoreductase
  • Tailoring (Unknown)
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  • AHA82002.1
  • arm33
 36073 - 37410 (+) Glycosyltransferase
  • Scaffold biosynthesis
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  • AHA82003.1
  • arm34
 37403 - 38113 (+) NDP-hexose-N,N-dimethyltransferase
  • Tailoring (Glycosylation)
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  • AHA82004.1
  • arm35
 38103 - 38723 (-) NDP-hexose-3,5-epimerase
  • Tailoring (Glycosylation)
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  • AHA82005.1
  • arm36
 38720 - 40273 (-) NDP-hexose-2,3-dehydratase
  • Tailoring (Glycosylation)
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  • AHA82006.1
 40441 - 40743 (+) transposase
  • Unknown
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Polyketide-specific information
Subclass Tetracycline
Starter unit Acetyl-CoA
Ketide length 20
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
arm5
+
arm4
+
arm7
+
arm8
+
arm2
+
arm3
+
arm9 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: V5OJFE3GCDVKSA62LSGPW5E6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
  • Removed duplicate gene name
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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