BGC0000213: colabomycin E biosynthetic gene cluster from Streptomyces aureus
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Location: 1 - 46,538 nt. (total: 46,538 nt).
This entry is originally from NCBI GenBank KF850685.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000213
Short description colabomycin E biosynthetic gene cluster from Streptomyces aureus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyene)
Loci NCBI GenBank: KF850685.1
Compounds
  • colabomycin E
Species Streptomyces aureus [taxonomy]
References
Chemical products information
colabomycin E
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C32H32N2O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIL50152.1
 205 - 858 (+) hypothetical protein
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  • AIL50153.1
 855 - 2408 (+) hypothetical protein
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  • AIL50154.1
 2405 - 4351 (+) hypothetical protein
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  • AIL50156.1
 4424 - 5776 (+) putative dioxygenase
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  • AIL50155.1
 5782 - 7218 (+) putative glutamine synthetase
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  • AIL50157.1
 7235 - 8377 (+) putative oxidoreductase
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  • AIL50158.1
 8251 - 9963 (-) putative feruolyl esterase
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  • AIL50159.1
 10258 - 11232 (+) putative nitrate ABC transport substrate-binding protein
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  • AIL50160.1
 11246 - 12421 (-) putative cytochrome P450
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  • AIL50161.1
 12596 - 14581 (+) hypothetical protein
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  • AIL50162.1
  • colH1
 14631 - 15533 (-) hypothetical protein
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  • AIL50163.1
  • colR5
 15655 - 16407 (-) regulatory protein
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  • AIL50164.1
  • colC16
 16644 - 17378 (-) DSBA oxido/reductase
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  • AIL50165.1
  • colC3
 17366 - 18505 (-) hypothetical protein
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  • AIL50166.1
  • colC4
 18502 - 19710 (-) putative beta-ketoacyl synthase
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  • AIL50167.1
  • colC5
 19712 - 19966 (-) putative ACP
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  • AIL50168.1
  • colC10
 20026 - 20766 (-) putative ketoreductase
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  • AIL50169.1
  • colC2
 20766 - 21623 (-) putative arylamine N-acetyltransferase
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  • AIL50170.1
  • colM1
 21914 - 23440 (-) putative transport protein
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  • AIL50171.1
  • colC15
 23534 - 24313 (-) putative type II thioesterase
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  • AIL50172.1
  • colC9
 24310 - 25113 (-) putative acyl dehydratase
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  • AIL50173.1
  • colC8
 25113 - 25547 (-) putative acyl dehydratase
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  • AIL50174.1
  • colA2
 25544 - 26953 (-) putative 3,4-AHBA carboxyl group adenylase
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  • AIL50175.1
  • colA1
 26971 - 28098 (-) putative 3,4-AHBA synthase
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  • AIL50176.1
  • colA3
 28393 - 29208 (+) putative 2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate synthase
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  • AIL50177.1
  • colC11
 29304 - 29582 (+) putative ACP
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  • AIL50178.1
  • colC12
 29579 - 29860 (+) putative 3,4-AHBA ACP
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  • AIL50179.1
  • colC13
 29850 - 31043 (+) putative type II PKS ketosynthase alpha subunit
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  • AIL50180.1
  • colC14
 31098 - 31835 (+) putative beta-ketoacyl synthase beta subunit (CLF)
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  • AIL50181.1
  • colE3
 31846 - 32970 (+) putative 4-hydroxyprotocolabomycin epoxidase
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  • AIL50182.1
  • colC7
 33051 - 33755 (-) putative ketoreductase
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  • AIL50183.1
  • colE2
 33854 - 34387 (-) putative flavin reductase
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  • AIL50184.1
  • colC6
 34403 - 34858 (-) putative thioesterase
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  • AIL50187.1
  • colR2
 35095 - 35673 (-) putative TetR family transcriptional regulator
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  • AIL50186.1
  • colR1
 35716 - 36357 (-) putative transcriptional regulator
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  • AIL50185.1
  • colC1
 36419 - 37126 (-) putative phosphopantetheinyl transferase
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  • AIL50188.1
  • colE1
 37513 - 38730 (+) putative protocolabomycin 4-hydroxylase
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  • AIL50189.1
  • colD3
 38800 - 40341 (-) putative 5-aminolevulinate CoA-ligase
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  • AIL50190.1
  • colD2
 40417 - 41646 (-) putative 5-aminolevulinate synthase
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  • AIL50191.1
  • colD1
 41726 - 43279 (-) putative amide synthetase
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  • AIL50192.1
  • colR3
 43561 - 44136 (-) putative TetR family transcriptional regulator
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  • AIL50193.1
 44298 - 44936 (+) hypothetical protein
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  • AIL50194.1
 44985 - 45716 (-) hypothetical protein
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  • AIL50195.1
 46301 - >46538 (+) hypothetical protein
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Polyketide-specific information
Subclass Polyene
Ketide length 9
Cyclic? no
Polyketide-synthases
Genes Properties Modules
colC13
+
colC4 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: XHMATMYJAZTXOWXACEUS7VTO, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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