BGC0000223: rabelomycin biosynthetic gene cluster from uncultured bacterium BAC AB649/1850
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Location: 1 - 66,898 nt. (total: 66,898 nt).
This entry is originally from NCBI GenBank HM193369.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000223
Short description rabelomycin biosynthetic gene cluster from uncultured bacterium BAC AB649/1850
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Angucycline)
Loci NCBI GenBank: HM193369.1
Compounds
  • rabelomycin
  • dehydrorabelomycin
  • fluostatin F
  • fluostatin G
  • fluostatin H
Species uncultured bacterium BAC AB649/1850 [taxonomy]
References
Chemical products information
rabelomycin
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C19H14O6
Chemical database entries
NPAtlas
PubCHEM
dehydrorabelomycin
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C19H12O5
Chemical database entries
PubCHEM
fluostatin F
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C19H14O6
Chemical database entries
NPAtlas
PubCHEM
fluostatin G
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C24H22O7
fluostatin H
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C24H22O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEE65458.1
 614 - 1570 (-) beta-lactamase domain protein
  • Other enzymatic
Sequence-based prediction
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  • AEE65459.1
 1680 - 2564 (-) bata-lactamase
  • Other enzymatic
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  • AEE65460.1
 2601 - 3557 (+) transcriptional regulater
  • Regulation
Sequence-based prediction
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  • AEE65461.1
 3794 - 5467 (-) carboxyl transferase
  • Tailoring (Carboxylation)
Sequence-based prediction
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  • AEE65462.1
 5440 - 6888 (-) oxygenase
  • Tailoring (Oxidation)
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  • AEE65463.1
 6885 - 8390 (-) Oxygenase reductase-like protein
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AEE65464.1
 8387 - 9337 (-) aromatase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AEE65465.1
 9361 - 10143 (-) ketoreductase
  • Tailoring (Reduction)
Sequence-based prediction
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  • AEE65466.1
 10156 - 10431 (-) acyl carrier protein
  • Scaffold biosynthesis
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  • AEE65467.1
 10428 - 11690 (-) chain length determinant
  • Scaffold biosynthesis
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  • AEE65468.1
 11687 - 12958 (-) ketoacyl synthase
  • Scaffold biosynthesis
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  • AEE65469.1
 12955 - 13284 (-) putative polyketide cyclase
  • Scaffold biosynthesis
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  • AEE65470.1
 13307 - 15043 (-) carboxylase, alpha subunit
  • Tailoring (Carboxylation)
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  • AEE65471.1
 15219 - 15905 (-) two component regulater
  • Regulation
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  • AEE65472.1
 16178 - 16579 (+) oxidase-related FMN-binding protein
  • Unknown
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  • AEE65473.1
 16708 - 18198 (+) oxygenase-like protein
  • Tailoring (Oxidation)
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  • AEE65474.1
 18230 - 18943 (+) oxidase-like protein
  • Tailoring (Oxidation)
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  • AEE65475.1
 18982 - 19521 (+) hypothetical protein
  • Unknown
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  • AEE65476.1
 19584 - 20678 (+) hypothetical protein
  • Unknown
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  • AEE65477.1
 20742 - 21503 (-) NAD-dependent epimerase/dehydratase
  • Tailoring (Epimerization)
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  • AEE65478.1
 21583 - 23058 (-) putative oxygenase
  • Tailoring (Oxidation)
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  • AEE65479.1
 23303 - 24526 (-) oxidoreductase
  • Tailoring (Unknown)
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  • AEE65480.1
 24532 - 25539 (-) putative O-methyltransferase
  • Tailoring (Methylation)
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  • AEE65481.1
 25792 - 26571 (+) hypothetical protein
  • Unknown
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  • AEE65522.1
 27526 - 28497 (-) alcohol dehydrogenase
  • Tailoring (Oxidation)
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  • AEE65482.1
 28497 - 29531 (-) 3-oxoacyl-(acyl carrier protein) synthase III
  • Scaffold biosynthesis
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  • AEE65483.1
 29557 - 30282 (-) short-chain dehydrogenase/reductase SDR
  • Tailoring (Reduction)
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  • AEE65484.1
 30279 - 31766 (-) monooxygenase
  • Tailoring (Monooxygenation)
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  • AEE65485.1
 31810 - 32802 (-) streptomycin biosynthesis operon regulator
  • Regulation
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  • AEE65486.1
 33136 - 34338 (+) Nitric-oxide synthase
  • Other enzymatic
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  • AEE65487.1
 34343 - 35182 (+) amidohydrolase-like protein
  • Tailoring (Hydrolysis)
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  • AEE65488.1
 35234 - 35635 (-) GCN5-related N-acetyltransferase
  • Tailoring (Acetylation)
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  • AEE65489.1
 35632 - 36906 (-) adenylosuccinate lyase
  • Tailoring (Hydrolysis)
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  • AEE65490.1
 37062 - 38558 (+) amidase
  • Tailoring (Amination)
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  • AEE65491.1
 38558 - 40063 (+) glutamine synthetase
  • Precursor biosynthesis
Sequence-based prediction
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  • AEE65492.1
 40142 - 40501 (+) putative ferredoxin
  • Other enzymatic
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  • AEE65493.1
 40498 - 42384 (+) hypothetical protein
  • Unknown
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  • AEE65494.1
 42374 - 43063 (-) response regulator
  • Regulation
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  • AEE65495.1
 43647 - 43910 (+) Hypothetical protein
  • Unknown
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  • AEE65496.1
 44467 - 46689 (-) PAS/PAC sensor signal transduction histidine kinase
  • Regulation
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  • AEE65497.1
 46815 - 47255 (+) ShdA
  • Transport
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  • AEE65498.1
 47504 - 48412 (+) antitoxin component
  • Unknown
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  • AEE65499.1
 48468 - 48659 (+) putative regulatory protein
  • Regulation
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  • AEE65500.1
 48916 - 49116 (+) putative regulatory protein
  • Regulation
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  • AEE65501.1
 49176 - 49718 (+) conserved hypothetical protein
  • Unknown
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  • AEE65502.1
 49751 - 50869 (-) geranylgeranyl reductase
  • Tailoring (Reduction)
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  • AEE65503.1
 50949 - 51494 (+) galactoside O-acetyltransferase
  • Tailoring (Acetylation)
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  • AEE65504.1
 51491 - 52057 (+) transcriptional regulator, TetR family
  • Regulation
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  • AEE65505.1
 52054 - 53262 (+) putative DeoR-type transcriptional regulator
  • Regulation
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  • AEE65506.1
 53273 - 53719 (-) hypothetical protein
  • Unknown
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  • AEE65507.1
 53718 - 54041 (+) AGR369Wp
  • Unknown
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  • AEE65508.1
 54188 - 54628 (+) hypothetical protein
  • Unknown
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  • AEE65509.1
 54701 - 55240 (+) intracellular protease
  • Other enzymatic
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  • AEE65510.1
 55266 - 56552 (-) integral membrane protein
  • Unknown
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  • AEE65511.1
 56591 - 57010 (-) NUDIX hydrolase
  • Unknown
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  • AEE65512.1
 57122 - 58060 (-) Ku protein
  • Unknown
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  • AEE65513.1
 58153 - 59100 (+) DNA polymerase LigD ligase region
  • Unknown
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  • AEE65514.1
 59093 - 60001 (+) DNA polymerase LigD, polymerase domain protein
  • Unknown
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  • AEE65515.1
 60063 - 60851 (+) hypothetical protein
  • Unknown
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  • AEE65516.1
 60934 - 61275 (+) transcriptional regulator, PadR-like family
  • Regulation
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  • AEE65517.1
 61272 - 61697 (+) hypothetical protein
  • Unknown
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  • AEE65518.1
 61694 - 63355 (-) helicase domain protein
  • Unknown
Sequence-based prediction
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  • AEE65519.1
 63393 - 65792 (-) hypothetical protein
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  • AEE65520.1
 65874 - 66107 (+) hypothetical protein
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  • AEE65521.1
 66104 - 66760 (+) hypothetical protein
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Polyketide-specific information
Subclass Angucycline
Starter unit Acetyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
AEE65469.1
+
AEE65468.1
+
AEE65464.1 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: V5OJFE3GCDVKSA62LSGPW5E6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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