BGC0000224: fredericamycin A biosynthetic gene cluster from Streptomyces griseus
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Location: 1 - 33,064 nt. (total: 33,064 nt).
This entry is originally from NCBI GenBank AF525490.2.

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core biosynthetic genes
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000224
Short description fredericamycin A biosynthetic gene cluster from Streptomyces griseus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: AF525490.2
Compounds
  • fredericamycin A
Species Streptomyces griseus [taxonomy]
References
Chemical products information
fredericamycin A
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C30H21N1O9
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAQ08909.1
 33 - 1631 (-) putative acyl CoA decarboxylase
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  • AAQ08910.1
 1727 - 2770 (+) putative acyl transferase
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  • AAQ08911.1
 2731 - 4920 (-) putative multicopper oxidase
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  • AAQ08912.1
 4971 - 5771 (+) putative 3-ketoacyl-ACP reductase
  • Tailoring (Reduction)
Other in vivo study
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  • AAQ08913.1
 5782 - 7263 (+) putative peptide transporter
  • Transport
Sequence-based prediction
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  • AAQ08914.1
 7420 - 7740 (+) putative polyketide cyclase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAQ08915.1
 7804 - 8229 (+) putative polyketide cyclase
  • Scaffold biosynthesis
Other in vivo study
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  • AAQ08916.1
 8226 - 9491 (+) 3-ketoacyl-ACP synthase
  • Scaffold biosynthesis
Activity assay
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  • AAQ08917.1
 9488 - 10699 (+) chain length factor
  • Scaffold biosynthesis
Activity assay
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  • AAQ08918.1
 10764 - 11018 (+) ACP
  • Scaffold biosynthesis
Activity assay
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  • AAQ08919.1
 11020 - 11487 (+) putative polyketide cyclase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AAQ08920.1
 11484 - 11807 (+) putative monooxygenase
  • Tailoring (Oxidation)
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  • AAQ08921.1
 11825 - 12259 (+) putative oxygenase
  • Tailoring (Oxidation)
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  • AAQ08922.1
 12333 - 13073 (-) putative monooxygenase
  • Tailoring (Oxidation)
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  • AAQ08923.1
 13111 - 13560 (-) putative monooxygenase
  • Tailoring (Hydroxylation)
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  • AAQ08924.1
 13801 - 14265 (+) putative monooxygenase
  • Tailoring (Hydroxylation)
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  • AAQ08925.1
 14322 - 15383 (+) putative o-methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AAQ08926.1
 15497 - 16246 (+) putative 3-ketoacyl-ACP reductase
  • Tailoring (Reduction)
Other in vivo study
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  • AAQ08927.1
 16248 - 16559 (+) putative monooxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AAQ08928.1
 16559 - 16876 (+) putative monooxygenase
  • Tailoring (Oxidation)
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  • AAQ08929.1
 17040 - 18041 (-) putative 3-keto-acyl-ACP synthase
  • Scaffold biosynthesis
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  • AAQ08930.1
 18122 - 19153 (-) putative membrane transporter
  • Transport
Sequence-based prediction
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  • AAQ08931.2
 19310 - 19741 (-) transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AAQ08932.2
 19943 - 20368 (+) Unknown
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  • AAQ08933.1
 20468 - 22336 (+) asparagine synthetase
  • Tailoring (Amination)
Activity assay
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  • AAQ08934.1
 22401 - 24236 (-) regulatory protein
  • Regulation
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Other in vivo study
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  • AAQ08935.1
 24472 - 26067 (+) putative membrane transporter
  • Transport
Sequence-based prediction
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  • AAQ08936.1
 26150 - 26629 (+) holo-ACP synthase
  • Scaffold biosynthesis
Activity assay
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  • AAQ08937.1
 26869 - 27381 (+) transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AAQ08938.1
 27689 - 28906 (+) transposase
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  • AAQ08939.1
 28988 - 30565 (+) putative membrane transporter
  • Transport
Sequence-based prediction
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  • AAQ08940.1
 30621 - 31229 (-) unknown
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  • AAQ08941.1
 31226 - 32515 (-) unknown
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Ketide length 15
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
AAQ08914.1
+
AAQ08915.1
+
AAQ08916.1 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: HPZ6LL7T2WJIC44FKRYGWFQ6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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