BGC0000225: frenolicin B biosynthetic gene cluster from Streptomyces roseofulvus
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Location: 1 - 25,306 nt. (total: 25,306 nt).
This entry is originally from NCBI GenBank AF058302.1.

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core biosynthetic genes
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Gene details
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000225
Short description frenolicin B biosynthetic gene cluster from Streptomyces roseofulvus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AF058302.1
Compounds
  • frenolicin B
Species Streptomyces roseofulvus [taxonomy]
References
Chemical products information
frenolicin B
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C18H16O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAC18096.1
  • frnA
 1563 - 3875 (+) FrnA
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  • AAC18097.1
  • frnB
 3872 - 4843 (+) membrane protein of putative ABC transporter
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  • AAC18098.1
  • frnC
 4947 - 5771 (+) membrane component of putative ABC transporter
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  • AAC18099.1
  • frnD
 5768 - 7342 (+) ATPase component of putative ABC transporter
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  • AAC18100.1
  • frnE
 7460 - 8110 (+) FrnE
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  • AAC18101.1
  • frnF
 8271 - 9824 (+) putative antibiotic antiporter
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  • AAC18102.1
  • frnG
 10091 - 10939 (+) pathway specific regulator
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  • AAC18103.1
  • frnH
 11033 - 11548 (-) actVB homolog
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  • AAC18104.1
  • frnI
 11545 - 12555 (-) putative four carbon starter unit synthase
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  • AAC18105.1
  • frnJ
 12736 - 12993 (+) acyl carrier protein
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  • AAC18106.1
  • frnK
 13081 - 14136 (-) putative acyltransferase for starter unit
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  • AAC18107.1
  • frnL
 14336 - 15613 (+) ketoacyl synthase
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  • AAC18108.1
  • frnM
 15694 - 16974 (+) chain length factor
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  • AAC18109.1
  • frnN
 17047 - 17298 (+) acyl carrier protein
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  • AAC18110.1
  • frnO
 17380 - 17862 (-) actVI-ORFA homolog
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  • AAC18111.1
  • frnP
 18015 - 18830 (+) ketoreductase
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  • AAC18112.1
  • frnQ
 18830 - 19825 (+) aromatase
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  • AAC18113.1
  • frnR
 19822 - 20766 (+) cyclase/dehydrase
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  • AAC18114.1
  • frnS
 20917 - 21834 (-) FrnS
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  • AAC18115.1
  • frnT
 21831 - 23021 (-) putative enoyl reductase
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  • AAC18116.1
  • frnU
 23106 - 23432 (-) quinone-forming monooxygenase
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  • AAC18117.1
  • gapX
 23613 - 24998 (-) glyceraldehyde-3-phosphate dehydrogenase homolog
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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