BGC0000275: tetracenomycin C biosynthetic gene cluster from Streptomyces glaucescens
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Location: 1 - 13,123 nt. (total: 13,123 nt).
This entry is originally from NCBI GenBank M80674.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
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Polyketide
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000275
Short description tetracenomycin C biosynthetic gene cluster from Streptomyces glaucescens
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Anthracycline)
Loci NCBI GenBank: M80674.1
Compounds
  • tetracenomycin C
Species Streptomyces glaucescens [taxonomy]
References
Chemical products information
tetracenomycin C
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C23H20O11
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAA67508.1
  • tcmR
 59 - >742 (-) tetracenomycin C resistance and export gene repressor
  • Regulation
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  • AAA67509.1
  • tcmA
 878 - 2494 (+) tetracenomycin C resistance and export protein
  • Transport
Sequence-based prediction
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  • AAA67510.1
  • tcmP
 2609 - >3424 (-) O-methyltransferase
  • Tailoring (Methylation)
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  • AAA67511.1
  • tcmG
 3954 - 5639 (+) hydroxylase
  • Tailoring (Hydroxylation)
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  • AAA67512.1
  • tcmH
 5644 - 5982 (+) monooxygenase
  • Tailoring (Oxidation)
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  • AAA67513.1
  • tcmI
 5985 - 6314 (+) cyclase
  • Scaffold biosynthesis
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  • AAA67514.1
  • tcmJ
 6328 - 6777 (+) predicted protein
  • Scaffold biosynthesis
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  • AAA67515.1
  • tcmK
 6779 - 8059 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
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  • AAA67516.1
  • tcmL
 8056 - 9285 (+) beta-ketoacyl synthase,chain length factor
  • Scaffold biosynthesis
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  • AAA67517.1
  • tcmM
 9358 - 9609 (+) acyl carrier protein
  • Scaffold biosynthesis
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  • AAA67518.1
  • tcmN
 9611 - 11095 (+) aromatase/cyclase
  • Scaffold biosynthesis
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  • AAA67519.1
  • tcmO
 11192 - 12211 (+) O-methyltransferase
  • Tailoring (Methylation)
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Polyketide-specific information
Subclass Anthracycline
Starter unit Acetyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
tcmK
+
tcmN 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: HPZ6LL7T2WJIC44FKRYGWFQ6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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