BGC0000290: A-47934 biosynthetic gene cluster from Streptomyces toyocaensis
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Location: 1 - 69,301 nt. (total: 69,301 nt).
This entry is originally from NCBI GenBank U82965.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000290
Short description A-47934 biosynthetic gene cluster from Streptomyces toyocaensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Glycopeptide stereochemistry is known not to correlate with the presence of E domains."
Biosynthetic class(es)
  • NRP (Glycopeptide)
Loci NCBI GenBank: U82965.2
Compounds
  • A-47934
Species Streptomyces toyocaensis [taxonomy]
References
Chemical products information
A-47934
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C58H44Cl3N7O21S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAM80527.1
 766 - 2022 (-) StaN
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  • AAM80528.1
 2485 - 4071 (-) StaM
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  • AAM80529.1
 4151 - 4963 (-) StaL
  • Tailoring (Sulfation)
Activity assay
Heterologous expression
Sequence-based prediction
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  • AAM80530.1
 4960 - 6267 (-) StaK
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  • AAM80531.1
 6312 - 7490 (-) StaJ
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  • AAM80532.1
 7534 - 9072 (-) StaI
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  • AAM80533.1
 9077 - 10273 (-) StaH
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  • AAM80534.1
 10263 - 11417 (-) StaG
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  • AAM80535.1
 11438 - 12613 (-) StaF
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  • AAM80536.1
 12951 - 18518 (-) StaD
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  • AAM80537.1
 18538 - 30738 (-) StaC
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  • AAM80538.1
 30768 - 35243 (-) StaB
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  • AAM80539.1
 35246 - 41458 (-) StaA
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  • AAM80540.1
 41455 - 43398 (-) StaU
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  • AAM80541.1
 43657 - 44352 (+) VanRst
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  • AAM80542.1
 44339 - 45442 (+) VanSst
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  • AAM80543.1
 45521 - 45985 (-) StaS
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  • AAM80544.1
 46330 - 49038 (+) StaR
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  • AAM80545.1
 49419 - 50222 (-) DpgD
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  • AAM80546.1
 50219 - 51535 (-) DpgC
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  • AAM80547.1
 51532 - 52209 (-) DpgB
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  • AAM80548.1
 52221 - 53393 (-) DpgA
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  • AAM80549.1
 53539 - 54897 (-) HpgT
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  • AAM80550.1
 55059 - 56213 (-) Pdh
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  • AAM80551.1
 56388 - 57497 (+) HmaS
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  • AAM80552.1
 57481 - 58581 (+) Hmo
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  • AAM80553.1
 58703 - 59704 (-) StaQ
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  • AAM80554.1
 61296 - 62138 (+) StaP
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  • AAM80555.1
 62227 - 63393 (+) StaO
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  • AAC23581.2
  • murX
 63406 - 64746 (-) MurX
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  • AAC23583.1
  • DLDHStoy
 64874 - 65866 (+) D-lactate dehydrogenase
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  • AAC23582.2
  • DdlM
 65854 - 66894 (+) D-alanine:D-alanine ligase-related protein
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  • AAD02118.1
  • vanXst
 66891 - 67517 (+) D-ala-D-ala dipeptidase
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  • AAD02119.1
 67715 - 69301 (+) unknown
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NRP-specific information
Subclass Glycopeptide
Cyclic? no
Release type
  • Hydrolysis
Thioesterase genes
  • AAM80536.1 (Type I)
NRP-synthases
Gene Modules
AAM80539.1
Module 1
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AAM80549.1, AAM80550.1, AAM80551.1, AAM80552.1
Condensation domain type: Unknown
Module 2
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
AAM80538.1
Module 3
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AAM80549.1, AAM80545.1, AAM80546.1, AAM80547.1, AAM80548.1
Condensation domain type: Unknown
AAM80537.1
Module 4
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AAM80549.1, AAM80550.1, AAM80551.1, AAM80552.1
Condensation domain type: Unknown
Module 5
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AAM80549.1, AAM80550.1, AAM80551.1, AAM80552.1
Condensation domain type: Unknown
Module 6
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AAM80528.1
Condensation domain type: Unknown
AAM80536.1
Module 7
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Genes encoding specified AA: AAM80549.1, AAM80545.1, AAM80546.1, AAM80547.1, AAM80548.1
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: L2Z4MI3G5WXN6AS52Y55RDTF, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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