BGC0000291: A54145 biosynthetic gene cluster from Streptomyces fradiae
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Location: 1 - 126,933 nt. (total: 126,933 nt).
This entry is originally from NCBI GenBank DQ118863.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000291
Short description A54145 biosynthetic gene cluster from Streptomyces fradiae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
DQ118863.1
via
Compounds
  • A54145
Species Streptomyces fradiae [taxonomy]
References
Chemical products information
A54145 Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAZ23044.1
 <5 - 851 (+) hypothetical protein
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    • AAZ23045.1
    		 848 - 2473 (+) probable p-aminobenzoyl-glutamate transporter
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      • AAZ23046.1
      		 3365 - 4900 (-) probable histidine ammonia-lyase
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        • AAZ23047.1
        		 5048 - 5815 (+) transcriptional regulator
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          • AAZ23048.1
          		 6739 - 7635 (+) probable hydrolase
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            • AAZ23049.1
            		 8966 - 10024 (+) possible oxidoreductase
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              • AAZ23050.1
              		 10027 - 10467 (+) hypothetical protein
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                • AAZ23051.1
                		 11363 - 12862 (-) probable sugar kinase
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                  • AAZ23052.1
                  		 13059 - 15098 (-) probable dehydrogenase
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                    • AAZ23053.1
                    		 15190 - 16359 (-) probable sugar isomerase
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                      • AAZ23054.1
                      		 18507 - 19304 (+) hypothetical protein
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                        • AAZ23055.1
                        		 19323 - 20366 (-) hypothetical protein
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                          • AAZ23056.1
                          		 20753 - 21838 (-) hypothetical protein
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                            • AAZ23057.1
                            		 21918 - 23210 (-) probable integral membrane protein
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                              • AAZ23058.1
                              		 23207 - 24364 (-) probable secreted protein
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                                • AAZ23059.1
                                		 24542 - 25225 (-) probable putative response regulator
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                                  • AAZ23060.1
                                  		 25222 - 26619 (-) probable sensor kinase
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                                    • AAZ23061.1
                                    		 26669 - 28321 (-) probable D-aminoacylase
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                                      • AAZ23062.1
                                      		 28359 - 29798 (-) possible permease
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                                        • AAZ23063.1
                                        		 29795 - 31207 (-) probable decarboxylase
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                                          • AAZ23064.1
                                          		 31333 - 33018 (-) possible DNA-binding protein
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                                            • AAZ23065.1
                                            		 33118 - 34419 (-) hypothetical protein
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                                              • AAZ23066.1
                                              		 34423 - 35001 (+) hypothetical protein
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                                                • AAZ23067.1
                                                		 34950 - 35426 (+) hypothetical protein
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                                                  • AAZ23068.1
                                                  		 35510 - 36931 (-) hypothetical protein
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                                                    • AAZ23069.1
                                                    		 37360 - 38181 (+) hypothetical protein
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                                                      • AAZ23070.1
                                                      		 38233 - 38958 (-) possible response regulator
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                                                        • AAZ23071.1
                                                        		 38955 - 39803 (-) possible sensor kinase
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                                                          • AAZ23072.1
                                                          		 39941 - 40651 (+) hypothetical protein
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                                                            • AAZ23073.1
                                                            		 40648 - 42957 (+) hypothetical protein
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                                                              • AAZ23074.1
                                                              • lptEF
                                                              		 43616 - 45814 (+) acyl-CoA ligase
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                                                                • AAZ23075.1
                                                                • lptA
                                                                		 45924 - 64802 (+) peptide synthetase
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                                                                  • AAZ23076.1
                                                                  • lptB
                                                                  		 64799 - 71230 (+) peptide synthetase
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                                                                    • AAZ23077.1
                                                                    • lptC
                                                                    		 71227 - 86967 (+) peptide synthetase
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                                                                      • AAZ23078.1
                                                                      • lptD
                                                                      		 86967 - 94121 (+) peptide synthetase
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                                                                        • AAZ23079.1
                                                                        • lptG
                                                                        		 94118 - 94360 (+) hypothetical protein
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                                                                          • AAZ23080.1
                                                                          • lptH
                                                                          		 94443 - 95237 (+) possible thioesterase
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                                                                            • AAZ23081.1
                                                                            • lptJ
                                                                            		 95249 - 96244 (+) hypothetical protein
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                                                                              • AAZ23082.1
                                                                              • lptK
                                                                              		 96241 - 97029 (+) possible O-methyltransferase
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                                                                                • AAZ23083.1
                                                                                • lptL
                                                                                		 97099 - 98058 (+) possible hydrolase
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                                                                                  • AAZ23084.1
                                                                                  • lptM
                                                                                  		 98058 - 99119 (+) possible ABC transporter
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                                                                                    • AAZ23085.1
                                                                                    • lptN
                                                                                    		 99116 - 99964 (+) possible ABC transporter permease
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                                                                                      • AAZ23086.1
                                                                                      • lptP
                                                                                      		 100029 - 100649 (-) hypothetical protein
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                                                                                        • AAZ23087.1
                                                                                        • lptI
                                                                                        		 101479 - 102537 (+) possible methyltransferase
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                                                                                          • AAZ23088.1
                                                                                          		 104185 - 105123 (+) possible regulator
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                                                                                            • AAZ23089.1
                                                                                            		 105287 - 105697 (+) hypothetical protein
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                                                                                              • AAZ23090.1
                                                                                              		 105694 - 105879 (-) hypothetical protein
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                                                                                                • AAZ23091.1
                                                                                                		 106395 - 107252 (-) possible transposase
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                                                                                                  • AAZ23092.1
                                                                                                  		 110701 - 112812 (-) possible protein kinase
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                                                                                                    • AAZ23093.1
                                                                                                    		 112824 - 113243 (-) hypothetical protein
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                                                                                                      • AAZ23094.1
                                                                                                      		 113931 - 114662 (-) possible transposase
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                                                                                                        • AAZ23095.1
                                                                                                        		 118101 - 119465 (+) possible DNA helicase
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                                                                                                          • AAZ23096.1
                                                                                                          		 118989 - 120017 (-) hypothetical protein
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                                                                                                            • AAZ23097.1
                                                                                                            		 120066 - 120731 (-) hypothetical protein
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                                                                                                              • AAZ23098.1
                                                                                                              		 121573 - 121971 (+) hypothetical protein
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                                                                                                                • AAZ23099.1
                                                                                                                		 122339 - 123214 (-) probable transposase
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                                                                                                                  • AAZ23100.1
                                                                                                                  		 123359 - 123673 (+) hypothetical protein
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                                                                                                                    • AAZ23101.1
                                                                                                                    		 123917 - 124387 (+) possible transposase
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                                                                                                                      • AAZ23102.1
                                                                                                                      		 124378 - 124752 (+) possible transposase
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                                                                                                                        • AAZ23103.1
                                                                                                                        		 125782 - 126729 (+) hypothetical protein
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                                                                                                                          Biosynthesis information

                                                                                                                          Biosynthetic modules

                                                                                                                          Name
                                                                                                                          Unk01
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptA
                                                                                                                          Substrates
                                                                                                                          tryptophan (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk02
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptA
                                                                                                                          Substrates
                                                                                                                          glutamic acid (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk03
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptA
                                                                                                                          Substrates
                                                                                                                          asparagine, 3-hydroxyasparagine (evidence: Structure-based inference, Knock-out studies)
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk04
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptA
                                                                                                                          Substrates
                                                                                                                          threonine (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk05
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptA
                                                                                                                          Substrates
                                                                                                                          glycine (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk06
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptB
                                                                                                                          Substrates
                                                                                                                          alanine (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk07
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptB
                                                                                                                          Substrates
                                                                                                                          aspartic acid (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk08
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptC
                                                                                                                          Substrates
                                                                                                                          lysine (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk09
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptC
                                                                                                                          Substrates
                                                                                                                          aspartic acid, 3-hydroxyaspartic acid, 3-methoxyaspartic acid (evidence: Structure-based inference, Knock-out studies)
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk10
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptC
                                                                                                                          Substrates
                                                                                                                          glycine (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk11
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptC
                                                                                                                          Substrates
                                                                                                                          asparagine (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk12
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptD
                                                                                                                          Substrates
                                                                                                                          3R-methylglutamic acid, glutamic acid (evidence: Structure-based inference, Knock-out studies)
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Name
                                                                                                                          Unk13
                                                                                                                          Type
                                                                                                                          nrps-type1
                                                                                                                          Genes
                                                                                                                          lptD
                                                                                                                          Substrates
                                                                                                                          isoleucine, valine (evidence: Structure-based inference [1])
                                                                                                                          Integrated Monomers
                                                                                                                          Domains
                                                                                                                          adenylation
                                                                                                                          Annotation changelog

                                                                                                                          Entry version: 4

                                                                                                                          Date
                                                                                                                          Changes
                                                                                                                          Submitters
                                                                                                                          Reviewers
                                                                                                                          2022-10-07
                                                                                                                          Update chemical activity to schema version 2.11
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                          Entry version: 3

                                                                                                                          Date
                                                                                                                          Changes
                                                                                                                          Submitters
                                                                                                                          Reviewers
                                                                                                                          2022-09-15
                                                                                                                          Updated bioactivity data
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                          2022-09-15
                                                                                                                          Added NRP substrate specificities
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                          Entry version: 2

                                                                                                                          Date
                                                                                                                          Changes
                                                                                                                          Submitters
                                                                                                                          Reviewers
                                                                                                                          2019-10-16
                                                                                                                          Migrated from v1.4
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                          Entry version: 1

                                                                                                                          Date
                                                                                                                          Changes
                                                                                                                          Submitters
                                                                                                                          Reviewers
                                                                                                                          2015-06-12
                                                                                                                          Submitted
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                                                                          Detailed domain annotation
                                                                                                                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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