BGC0000327: netropsin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
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Location: 1,082,965 - 1,112,107 nt. (total: 29,143 nt).
This entry is originally from NCBI GenBank AM238664.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000327
Short description netropsin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AM238664.2
Compounds
  • netropsin
Species Streptomyces ambofaciens ATCC 23877 [taxonomy]
References
Chemical products information
netropsin
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C18H26N10O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAMR0900
  • CAJ88609.1
 1082965 - 1083330 (-) putative nonribosomal peptide synthetase
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  • SAMR0901
  • CAJ88610.1
 1083388 - 1086591 (-) putative non-ribosomal peptide synthetase
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  • SAMR0902
  • CAJ88611.1
 1086588 - 1087634 (-) putative dehydrogenase
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  • SAMR0903
  • CAJ88612.1
 1087631 - 1088968 (-) putative non ribosomal peptide synthetase
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  • SAMR0904
  • CAJ88613.1
 1088992 - 1089765 (-) putative SAM-dependent methyltransferase
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  • SAMR0905
  • CAJ88614.1
 1089805 - 1090578 (-) putative metal-dependent hydrolase of the TIM-barrel fold
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  • SAMR0906
  • CAJ88615.1
 1090710 - 1092635 (-) conserved hypothetical protein
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  • SAMR0907
  • CAJ88616.1
 1092623 - 1093768 (-) putative lipopolysaccharide biosynthesis protein
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  • SAMR0908
  • CAJ88617.1
 1093765 - 1094529 (-) putative nucleoside-diphosphate-sugar pyrophosphorylase
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  • SAMR0909
  • CAJ88618.1
 1094526 - 1095542 (-) putative glycosyl transferase
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  • SAMR0910
  • CAJ88619.1
 1095605 - 1096588 (-) putative epimerase
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  • SAMR0911
  • CAJ88620.1
 1096581 - 1097852 (-) putative UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase
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  • SAMR0912
  • CAJ88621.1
 1097935 - 1099068 (-) hypothetical protein
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  • SAMR0913
  • CAJ88622.1
 1099116 - 1099937 (-) putative creatinase
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  • SAMR0914
  • CAJ88623.1
 1099948 - 1100841 (-) putative hihydroorotate dehydrogenase
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  • SAMR0915
  • CAJ88624.1
 1100838 - 1101383 (-) conserved hypothetical protein
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  • SAMR0916
  • CAJ88625.1
 1101380 - 1102828 (-) putative aldehyde dehydrogenase
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  • SAMR0917
  • CAJ88626.1
 1103647 - 1105059 (-) putative non-ribosomal antibiotic-related peptide synthase
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  • SAMR0918
  • CAJ88627.1
 1105399 - 1106070 (-) putative two component response regulator-like
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  • SAMR0919
  • CAJ88628.1
 1106811 - 1108670 (+) putative netropsin resistance protein subunit 1
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  • SAMR0920
  • CAJ88629.1
 1108670 - 1110505 (+) putative netropsin resistance protein subunit 2
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  • SAMR0921
  • CAJ88630.1
 1110509 - 1112107 (+) putative acyl-CoA synthetase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
SAMR0901
Module ?
Specificity: guanidinoacetic acid
Evidence for specificity:
  • Structure-based inference
  • ATP-PPi exchange assay
SAMR0921
Module ?
Specificity: 4-acetamidopyrrole-2-carboxylic acid
Evidence for specificity:
  • Structure-based inference
  • ATP-PPi exchange assay
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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