BGC0000333: cyclomarin D biosynthetic gene cluster from Salinispora arenicola CNS-205
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Location: 5,140,169 - 5,187,645 nt. (total: 47,477 nt).
This entry is originally from NCBI GenBank CP000850.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000333
Short description cyclomarin D biosynthetic gene cluster from Salinispora arenicola CNS-205
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CP000850.1
Compounds
  • cyclomarin D
Species Salinispora arenicola CNS-205 [taxonomy]
References
Chemical products information
cyclomarin D
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C55H80N8O10
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Sare_4547
  • ABW00316.1
 5140169 - 5141329 (-) pyruvate phosphate dikinase PEP/pyruvate-binding
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  • Sare_4548
  • ABW00317.1
 5141420 - 5142064 (+) conserved hypothetical protein
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  • Sare_4549
  • ABW00318.1
 5142074 - 5142676 (+) Phosphoglycerate mutase
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  • Sare_4550
  • ABW00319.1
 5142742 - 5143686 (+) daunorubicin resistance ABC transporter ATPase subunit
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  • Sare_4551
  • ABW00320.1
 5143683 - 5144477 (+) ABC-2 type transporter
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  • Sare_4552
  • ABW00321.1
 5144395 - 5147526 (-) transcriptional regulator, winged helix family
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  • Sare_4553
  • ABW00322.1
 5147696 - 5148910 (+) cytochrome P450
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  • Sare_4554
  • ABW00323.1
 5148907 - 5149698 (+) methyltransferase FkbM family
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  • Sare_4555
  • ABW00324.1
 5149695 - 5150423 (+) Thioesterase
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  • Sare_4556
  • ABW00325.1
 5150433 - 5150924 (+) hypothetical protein
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  • Sare_4557
  • ABW00326.1
 5150951 - 5152213 (-) cytochrome P450
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  • Sare_4558
  • ABW00327.1
 5152562 - 5153386 (+) transposase IS4 family protein
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  • Sare_4559
  • ABW00328.1
 5153724 - 5156357 (+) transcriptional regulator, LuxR family
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  • Sare_4560
  • ABW00329.1
 5156489 - 5157676 (+) cytochrome P450
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  • Sare_4561
  • ABW00330.1
 5157756 - 5158550 (+) Phytanoyl-CoA dioxygenase
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  • Sare_4562
  • ABW00331.1
 5158591 - 5181948 (+) amino acid adenylation domain
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  • Sare_4563
  • ABW00332.1
 5181948 - 5182163 (+) MbtH domain protein
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  • Sare_4564
  • ABW00333.1
 5182167 - 5182757 (+) isopentenyl-diphosphate delta-isomerase, type 1
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  • Sare_4565
  • ABW00334.1
 5182801 - 5183922 (+) hypothetical protein
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  • Sare_4566
  • ABW00335.1
 5183919 - 5184806 (+) Acetaldehyde dehydrogenase
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  • Sare_4567
  • ABW00336.1
 5184806 - 5185852 (+) pyruvate carboxyltransferase
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  • Sare_4568
  • ABW00337.1
 5185871 - 5186854 (+) Methyltransferase type 12
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  • Sare_4569
  • ABW00338.1
 5186851 - 5187645 (+) 4-oxalocrotonate decarboxylase
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NRP-specific information
Subclass N/A
Cyclic? yes
Release type
  • Macrolactamization
Thioesterase genes
  • Sare_4565 (Type I)
NRP-synthases
Gene Modules
Sare_4562
Module 7
Specificity: 2-amino-3,5-dimethyl-4-hexenoic Acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 6
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 5
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 4
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 3
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 2
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Module 1
Specificity: tryptophan / 1-(1,1-dimethylallyl)-tryptophan / N-(1-methyl)-tryptophan / N-(1-propargyl)-tryptophan
Evidence for specificity:
  • Feeding study
  • Knock-out studies
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FGOE6VD55GZRETNYSNOKUJZO, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Corrected NRP gene names
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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