BGC0000336: daptomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
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Location: 45,828 - 108,856 nt. (total: 63,029 nt).
This entry is originally from NCBI GenBank AY787762.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000336
Short description daptomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AY787762.1
Compounds
  • daptomycin
Species Streptomyces filamentosus NRRL 11379 [taxonomy]
References
Chemical products information
daptomycin
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C72H101N17O26
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAX31552.1
  • dptP
 45829 - 46449 (-) hypothetical protein
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  • AAX31553.1
  • dptM
 47208 - 48167 (+) putative ABC transporter ATP-binding protein
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  • AAX31554.1
  • dptN
 48161 - 49030 (+) putative ABC transporter permease
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  • AAX31555.1
  • dptE
 49421 - 51214 (+) acyl-CoA ligase
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  • AAX31556.1
  • dptF
 51283 - 51552 (+) probable acyl carrier protein
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  • AAX31557.1
  • dptA
 51568 - 69060 (+) peptide synthetase 1
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  • AAX31558.1
  • dptBC
 69057 - 91073 (+) peptide synthetase 2
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  • AAX31559.1
  • dptD
 91070 - 98209 (+) peptide synthetase 3
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  • AAX31560.1
  • dptG
 98283 - 98510 (+) putative esterase
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  • AAX31561.1
  • dptH
 98548 - 99363 (+) putative hydrolase
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  • AAX31562.1
  • dptI
 99447 - 100433 (+) hypothetical protein
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  • AAX31563.1
  • dptJ
 100430 - 101167 (+) putative oxidoreductase
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  • AAX31564.1
 102921 - 103574 (+) probable phosphatase
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  • AAX31565.1
 103684 - 106551 (-) putative neutral metalloprotease
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  • AAX31566.1
  • dptR1
 106688 - 107713 (+) probable regulatory protein
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  • AAX31567.1
  • dptR2
 107741 - 108856 (-) probable transcriptional regulator
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
dptA
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Module ?
Specificity: asparagine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Module ?
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Module ?
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
dptBC
Module ?
Specificity: ornithine
Evidence for specificity:
Module ?
Specificity: aspartic acid
Evidence for specificity:
Module ?
Specificity: alanine
Evidence for specificity:
Module ?
Specificity: aspartic acid
Evidence for specificity:
Module ?
Specificity: glycine
Evidence for specificity:
Module ?
Specificity: serine
Evidence for specificity:
dptD
Module ?
Specificity: 3R-methylglutamic acid
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Module ?
Specificity: kynurenine
Evidence for specificity:
  • Sequence-based prediction
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Refined reference coordinates
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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