BGC0000350: ET-743 biosynthetic gene cluster from uncultured organism
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Location: 1 - 35,392 nt. (total: 35,392 nt).
This entry is originally from NCBI GenBank HQ609499.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000350
Short description ET-743 biosynthetic gene cluster from uncultured organism
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
HQ609499.1
via Enzymatic assays
Compounds
  • ET-743
Species uncultured organism [taxonomy]
References
Chemical products information
ET-743 Evidence:
Copy SMILES
C39H43N3O11S1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ETU_000001
  • ADQ55468.1
 <1 - 1167 (-) acetyl-CoA carboxylase biotin carboxylase subunit
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    • ETU_000002
    • ADQ55469.1
    		 1215 - 1673 (-) acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
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      • ETU_000003
      • ADQ55470.1
      		 2074 - 2862 (-) Mg-dependent DNase
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        • ETU_000004
        • ADQ55471.1
        		 2954 - 3868 (-) DNA polymerase III delta prime subunit
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          • ETU_000005
          • ADQ55472.1
          		 4283 - 5089 (+) hypothetical 29 kDa protein
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            • ETU_000006
            • ADQ55473.1
            		 5154 - 6239 (+) SAM-dependent methyltransferase
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              • ETU_000007
              • ADQ55474.1
              		 6255 - 8201 (+) NRPS
              • Scaffold biosynthesis
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              • ETU_000008
              • ADQ55475.1
              		 8319 - 12653 (+) NRPS
              • Scaffold biosynthesis
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              • ETU_000009
              • ADQ55476.1
              		 12734 - 18106 (+) NRPS
              • Scaffold biosynthesis
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              • ETU_000010
              • ADQ55477.1
              		 18099 - 20105 (+) pyruvate dehydrogenase E1 component
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                • ETU_000011
                • ADQ55478.1
                		 20074 - 21171 (+) pyruvate dehydrogenase E2 component
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                  • ETU_000012
                  • ADQ55479.1
                  		 21249 - 22742 (+) FAD-binding monooxygenase
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                    • ETU_000013
                    • ADQ55480.1
                    		 22720 - 23382 (-) O-methyltransferase family 3
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                      • ETU_000014
                      • ADQ55481.1
                      		 23389 - 23868 (-) catechol hydroxylase
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                        • ETU_000015
                        • ADQ55482.1
                        		 24066 - 24407 (-) transcriptional regulator MerR family
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                          • ETU_000016
                          • ADQ55483.1
                          		 24434 - 26680 (-) penicillin acylase
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                            • ETU_000017
                            • ADQ55484.1
                            		 26897 - 28357 (-) aspartyl glutamyl-tRNA Asn Gln amidotransferase subunit B
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                              • ETU_000018
                              • ADQ55485.1
                              		 28368 - 29549 (-) aspartyl glutamyl-tRNA Asn Gln amidotransferase subunit A
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                                • ETU_000019
                                • ADQ55486.1
                                		 29878 - 30186 (-) aspartyl glutamyl-tRNA Asn Gln amidotransferase subunit C
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                                  • ETU_000020
                                  • ADQ55487.1
                                  		 30383 - 31828 (+) peptidase U62
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                                    • ETU_000021
                                    • ADQ55488.1
                                    		 31961 - 32491 (+) shikimate kinase I
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                                      • ETU_000022
                                      • ADQ55489.1
                                      		 32712 - 33116 (-) DnaK suppressor protein
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                                        • ETU_000023
                                        • ADQ55490.1
                                        		 33226 - 34143 (-) putative drug_metabolite transporter superfamily protein
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                                          • ETU_000024
                                          • ADQ55491.1
                                          • polA
                                          		 34413 - 35036 (+) DNA polymerase I
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                                            • ETU_000025
                                            • ADQ55492.1
                                            		 35042 - >35392 (+) hypothetical protein
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                                              Biosynthesis information

                                              Biosynthetic modules

                                              Name
                                              0
                                              Type
                                              nrps-type1
                                              Genes
                                              ETU_000009
                                              Substrates
                                              fatty acid (evidence: Structure-based inference)
                                              Integrated Monomers
                                              Domains
                                              condensation, adenylation
                                              Name
                                              1
                                              Type
                                              nrps-type1
                                              Genes
                                              ETU_000009
                                              Substrates
                                              cysteine (evidence: Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              condensation, adenylation
                                              Name
                                              2
                                              Type
                                              nrps-type1
                                              Genes
                                              ETU_000007
                                              Substrates
                                              glycolic acid (evidence: Sequence-based prediction)
                                              Integrated Monomers
                                              Domains
                                              condensation, adenylation
                                              Name
                                              3
                                              Type
                                              nrps-type1
                                              Genes
                                              ETU_000008
                                              Substrates
                                              3-hydroxy-O-methyl-5-methyltyrosine (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Annotation changelog

                                              Entry version: 4

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-10-07
                                              Update chemical activity to schema version 2.11
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 3

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Corrected NRP module activity
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2022-09-15
                                              Corrected NRP substrate specificities
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2022-09-15
                                              Updated NRP substrate specificities
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Migrated from v1.4
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2015-06-12
                                              Submitted
                                              • (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                              Detailed domain annotation
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