BGC0000366: gobichelin A biosynthetic gene cluster from Streptomyces sp. NRRL F-4415
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Location: 1 - 36,842 nt. (total: 36,842 nt).
This entry is originally from NCBI GenBank KC215181.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000366
Short description gobichelin A biosynthetic gene cluster from Streptomyces sp. NRRL F-4415
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KC215181.1
via
Compounds
  • gobichelin A
  • gobichelin B
Species Streptomyces sp. NRRL F-4415 [taxonomy]
References
Chemical products information
gobichelin A Evidence:
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C30H41N9O9
Chemical database entries
NPAtlas
gobichelin B Evidence:
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C30H41N9O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGE11883.1
  • gobA
 183 - 806 (+) TetR transcriptional regulator
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    • AGE11884.1
    • gobB
    		 1044 - 1874 (-) NH3 dependent NAD+ synthase
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      • AGE11885.1
      • gobC
      		 2103 - 2756 (-) hypothetical protein
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        • AGE11886.1
        • gobD
        		 2990 - 3457 (-) acetyltransferase
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          • AGE11887.1
          • gobE
          		 3803 - 4459 (+) isochorismatase
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            • AGE11888.1
            • gobF
            		 4479 - 4775 (+) hypothetical protein
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              • AGE11889.1
              • gobG
              		 5111 - 5713 (+) amidinotransferase
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                • AGE11890.1
                • gobH
                		 5869 - 7338 (-) salicylate synthase
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                  • AGE11891.1
                  • gobJ
                  		 8437 - 12144 (-) nonribosomal peptide synthetase
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                    • AGE11892.1
                    • gobK
                    		 12184 - 13917 (+) 2,3-dihydroxybenzoate-AMP ligase
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                      • AGE11893.1
                      • gobL
                      		 13945 - 14187 (+) MbtH
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                        • AGE11894.1
                        • gobM
                        		 14251 - 15312 (-) iron siderophore uptake ABC system
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                          • AGE11895.1
                          • gobN
                          		 15407 - 16243 (-) ABC transporter
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                            • AGE11896.1
                            • gobO
                            		 16246 - 17331 (-) ABC transporter
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                              • AGE11897.1
                              • gobP
                              		 17335 - 18396 (+) iron siderophore transporter
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                                • AGE11898.1
                                • gobR
                                		 20174 - 27922 (+) nonribosomal peptide synthetase
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                                  • AGE11899.1
                                  • gobS
                                  		 27919 - 34965 (+) nonribosomal peptide synthetase
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                                    • AGE11900.1
                                    • gobT
                                    		 35036 - 36463 (-) L-ornithine 5-monooxygenase
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      Unk01
                                      Type
                                      nrps-type1
                                      Genes
                                      gobJ
                                      Substrates
                                      serine (evidence: Structure-based inference, Radio labelling)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk02
                                      Type
                                      nrps-type1
                                      Genes
                                      gobK
                                      Substrates
                                      salicylic acid (evidence: Structure-based inference [1])
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk03
                                      Type
                                      nrps-type1
                                      Genes
                                      gobR
                                      Substrates
                                      histidine (evidence: Structure-based inference, Radio labelling)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk04
                                      Type
                                      nrps-type1
                                      Genes
                                      gobR
                                      Substrates
                                      lysine (evidence: Structure-based inference [1])
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk05
                                      Type
                                      nrps-type1
                                      Genes
                                      gobS
                                      Substrates
                                      serine (evidence: Structure-based inference [1])
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk06
                                      Type
                                      nrps-type1
                                      Genes
                                      gobS
                                      Substrates
                                      N5-hydroxyornithine (evidence: Structure-based inference, Homology)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Added NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated compound(s) information (NPAtlas curation)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-06-12
                                      Submitted
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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