BGC0000381: lichenysin biosynthetic gene cluster from Bacillus licheniformis DSM 13 = ATCC 14580
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Location: 370,023 - 408,881 nt. (total: 38,859 nt).
This entry is originally from NCBI GenBank AE017333.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000381
Short description lichenysin biosynthetic gene cluster from Bacillus licheniformis DSM 13 = ATCC 14580
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AE017333.1
370023 - 408881
via
Compounds
  • lichenysin
Species Bacillus licheniformis DSM 13 = ATCC 14580 [taxonomy]
References
Chemical products information
lichenysin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BLi00395
  • AAU39353.1
  • hyuA1
 370023 - 372077 (+) hydantoinase A
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    • BLi00396
    • AAU39354.1
    • hyuB1
    		 372080 - 374074 (+) hydantoinase B
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      • BLi00397
      • AAU39355.1
      		 374077 - 375159 (+) putative spermidine/putrescine ABC transporter solute-binding protein
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        • BLi00398
        • AAU39356.1
        		 375169 - 376287 (+) putative spermidine/putrescine ABC transporter ATP-binding protein
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          • BLi00399
          • AAU39357.1
          		 376274 - 377140 (+) putative spermidine/putrescine ABC transporter permease
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            • BLi00400
            • AAU39358.1
            		 377133 - 377945 (+) putative spermidine/putrescine ABC transporter permease
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              • BLi00401
              • AAU39359.1
              • lchAA
              		 378683 - 389425 (+) lichenysin synthase LchAA
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                • BLi00402
                • AAU39360.1
                • lchAB
                		 389445 - 400211 (+) lichenysin synthase LchAB
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                  • BLi00403
                  • AAU39361.1
                  • lchAC
                  		 400269 - 404117 (+) lichenysin synthase LchAC
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                    • BLi00404
                    • AAU39362.1
                    • lchAD
                    		 404121 - 404861 (+) lichenysin synthase LchAD
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                      • BLi00405
                      • AAU39363.1
                      • ycxC
                      		 404908 - 405819 (-) putative transporter YcxC
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                        • BLi00406
                        • AAU39364.1
                        • ycxD
                        		 405955 - 407304 (+) putative PLP-dependent transcriptional regulator YcxD
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                          • BLi00407
                          • AAU39365.1
                          • sfp
                          		 407316 - 407996 (-) 4'-phosphopantetheinyl transferase Sfp
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                            • BLi00408
                            • AAU39366.1
                            		 408066 - 408881 (+) putative esterase
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              lchAA
                              Substrates
                              glutamine (evidence: Structure-based inference, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              lchAA
                              Substrates
                              leucine (evidence: Structure-based inference, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              lchAA
                              Substrates
                              leucine (evidence: Structure-based inference, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              lchAB
                              Substrates
                              valine (evidence: Structure-based inference, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk05
                              Type
                              nrps-type1
                              Genes
                              lchAB
                              Substrates
                              aspartic acid (evidence: Structure-based inference, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk06
                              Type
                              nrps-type1
                              Genes
                              lchAB
                              Substrates
                              leucine (evidence: Structure-based inference, Homology)
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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