BGC0000388: mannopeptimycin biosynthetic gene cluster from Streptomyces hygroscopicus
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Location: 1 - 48,200 nt. (total: 48,200 nt).
This entry is originally from NCBI GenBank AY735112.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000388
Short description mannopeptimycin biosynthetic gene cluster from Streptomyces hygroscopicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AY735112.1
via
Compounds
  • mannopeptimycin
Species Streptomyces hygroscopicus [taxonomy]
References
Chemical products information
mannopeptimycin Evidence: Mass spectrometry [1]
Copy SMILES
C58H86N12O26
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAU34194.1
  • mppC
 77 - 1048 (+) acetyltransferase MppC
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    • AAU34195.1
    • mppD
    		 1045 - 2460 (+) sugar binding protein MppD
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      • AAU34196.1
      • mppE
      		 2495 - 3406 (+) ABC transporter MppE
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        • AAU34197.1
        • mppF
        		 3403 - 4293 (+) ABC transporter MppF
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          • AAU34198.1
          • mppG
          		 4359 - 5636 (+) polyprenyl mannose synthase MppG
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            • AAU34199.1
            • mppH
            		 5822 - 7234 (+) polyprenyl phospho-mannosyltransferase MppH
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              • AAU34200.1
              • mppI
              		 7293 - 8822 (+) polyprenyl phospho-mannosyltransferase MppI
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                • AAU34201.1
                • mppJ
                		 9012 - 10025 (+) methyltransferase MppJ
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                  • AAU34202.1
                  • mppA
                  		 10069 - 18312 (+) mannopeptimycin peptide synthetase MppA
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                    • AAU34203.1
                    • mppB
                    		 18309 - 29315 (+) mannopeptimycin peptide synthetase MppB
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                      • AAU34204.1
                      • mppK
                      		 29319 - 30638 (+) alpha/beta hydrolase MppK
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                        • AAU34205.1
                        • mppL
                        		 30658 - 32010 (+) ABC transporter MppL
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                          • AAU34206.1
                          • mppM
                          		 32181 - 33407 (+) isovaleryltransferase MppM
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                            • AAU34207.1
                            • mppN
                            		 33422 - 34792 (+) isovaleryltransferase MppN
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                              • AAU34208.1
                              • mppO
                              		 34905 - 35930 (+) predicted non-heme iron hydroxylase MppO
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                                • AAU34209.1
                                • mppP
                                		 36383 - 37264 (+) PLP-dependent aminotransferase MppP
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                                  • AAU34210.1
                                  • mppQ
                                  		 37264 - 38511 (+) PLP-dependent aminotransferase MppQ
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                                    • AAU34211.1
                                    • mppR
                                    		 38466 - 39374 (+) conserved hypothetical protein MppR
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                                      • AAU34212.1
                                      • mppS
                                      		 39389 - 40378 (+) putative transcriptional regulator MppS
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                                        • AAU34213.1
                                        • mppT
                                        		 40440 - 40655 (+) conserved hypothetical protein MppT
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                                          • AAU34214.1
                                          • mppU
                                          		 40773 - 41441 (+) two component response regulator MppU
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                                            • AAU34215.1
                                            • mppV
                                            		 41586 - 42758 (+) two component sensor kinase MppV
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                                              • AAU34216.1
                                              • mppW
                                              		 42817 - 43245 (+) hypothetical lipoprotein MppW
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                                                • AAU34217.1
                                                • mppX
                                                		 43248 - 44168 (+) ABC transporter MppX
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                                                  • AAU34218.1
                                                  • mppY
                                                  		 44182 - 45813 (+) conserved hypothetical protein MppY
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                                                    • AAU34219.1
                                                    • mppZ
                                                    		 46384 - 47649 (+) conserved hypothetical protein MppZ
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                                                      • AAU34220.1
                                                      • mppZ1
                                                      		 47770 - 48180 (+) lactone-dependent transcriptional regulator MppZ1
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                                                        Biosynthesis information

                                                        Biosynthetic modules

                                                        Name
                                                        Unk01
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        mppA
                                                        Substrates
                                                        serine (evidence: Structure-based inference [2])
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk02
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        mppA
                                                        Substrates
                                                        glycine (evidence: Structure-based inference [2])
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk03
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        mppA
                                                        Substrates
                                                        phenylalanine (evidence: Structure-based inference [2])
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk04
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        mppB
                                                        Substrates
                                                        tyrosine (evidence: Structure-based inference [2])
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Name
                                                        Unk05
                                                        Type
                                                        nrps-type1
                                                        Genes
                                                        mppB
                                                        Substrates
                                                        S-beta-hydroxyenduracididine (evidence: ATP-PPi exchange assay, Structure-based inference)
                                                        Integrated Monomers
                                                        Domains
                                                        adenylation
                                                        Annotation changelog

                                                        Entry version: 5

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2024-06-14
                                                        MIBiG v4 annotathon
                                                        • (ID: ZIPMIDQTGZMQXPYXCBVJOFMN)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 4

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 3

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Updated bioactivity data
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Added NRP substrate specificities
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2019-10-16
                                                        Migrated from v1.4
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2015-06-12
                                                        Submitted
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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