BGC0000405: δ-(L-α-aminoadipyl)-L-cysteine-D-valine biosynthetic gene cluster from Penicillium chrysogenum
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Location: 1 - 59,497 nt. (total: 59,497 nt).
This entry is originally from NCBI GenBank EF601124.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000405
Short description δ-(L-α-aminoadipyl)-L-cysteine-D-valine biosynthetic gene cluster from Penicillium chrysogenum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Beta-lactam)
Loci NCBI GenBank: EF601124.1
Compounds
  • δ-(L-α-aminoadipyl)-L-cysteine-D-valine
  • isopenicillin N
  • benzylpenicillin
  • phenoxymethylpenicillin
Species Penicillium chrysogenum [taxonomy]
References
Chemical products information
δ-(L-α-aminoadipyl)-L-cysteine-D-valine [synonyms: acv]
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C14H24N3O6S1
Chemical database entries
ChEBI
isopenicillin N [synonyms: ipn]
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C14H21N3O6S1
Chemical database entries
ChEBI
benzylpenicillin [synonyms: penicillin g]
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C16H17N2Na1O4S1
Chemical database entries
ChEBI
phenoxymethylpenicillin [synonyms: penicillin v]
(no structure information available)
C16H18N2O5S1
Chemical database entries
ChEMBL
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABR12607.1
 1 - 1659 (-) isoamyl alcohol oxidase
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  • ABR12608.1
 4468 - 5130 (-) hypothetical protein
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  • ABR12609.1
 5821 - 7011 (-) hypothetical protein
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  • ABR12610.1
 7456 - 8991 (+) hypothetical protein
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  • ABR12611.1
 9836 - 12187 (+) hypothetical protein
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  • ABR12612.1
 14735 - 15622 (+) hypothetical protein
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  • ABR12613.1
 16080 - 17960 (-) hypothetical protein
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  • ABR12614.1
 18585 - 20930 (-) hypothetical protein
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  • ABR12615.1
  • pcbAB
 25677 - 37052 (-) ACV synthetase
  • Scaffold biosynthesis
  • Mutation phenotype: no penicillin production
 Activity assay
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  • ABR12616.1
  • pcbC
 38068 - 39063 (+) IPN synthase
  • Tailoring (Oxidation)
  • Mutation phenotype: accumulation of ACV tripeptide
 Activity assay
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  • ABR12617.1
  • penDE
 40561 - 41835 (+) IPN:acyltransferase
  • Tailoring (Unknown)
  • Mutation phenotype: accumulation of isopenicillin N
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  • ABR12618.1
 42849 - 43628 (-) probable oxidoreductase
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  • ABR12619.1
 44942 - 46297 (+) hypothetical protein
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  • ABR12620.1
 49317 - 49781 (+) hypothetical protein
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  • ABR12621.1
 50291 - 50914 (+) hypothetical protein
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  • ABR12622.1
  • erg25
 56117 - 57262 (-) C4-methylsterol oxidase
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NRP-specific information
Subclass Beta-lactam
Cyclic? no
Release type
  • Macrolactamization
NRP-synthases
Gene Modules
pcbAB
Module 0
Specificity: 2-aminoadipic acid
Evidence for specificity:
  • ACVS assay
Module 1
Specificity: cysteine
Evidence for specificity:
  • ACVS assay
Condensation domain type: DCL
Module 2
Specificity: valine
Evidence for specificity:
  • ACVS assay
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 53KWSSAVU3NHQPX32A2FHV6D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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