BGC0000415: quinomycin biosynthetic gene cluster from Streptomyces griseovariabilis subsp. bandungensis
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Location: 1 - 36,568 nt. (total: 36,568 nt).
This entry is originally from NCBI GenBank JN852959.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000415
Short description quinomycin biosynthetic gene cluster from Streptomyces griseovariabilis subsp. bandungensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
JN852959.1
via
Compounds
  • quinomycin
Species Streptomyces griseovariabilis subsp. bandungensis [taxonomy]
References
Chemical products information
quinomycin Evidence:
Copy SMILES
C51H64N12O12S2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AET98900.1
  • qui1
 <5 - 155 (+) putative ABC transporter
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    • AET98901.1
    • qui2
    		 152 - 976 (+) putative ABC transporter
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      • AET98902.1
      • qui3
      		 1083 - 2288 (+) putative esterase
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        • AET98903.1
        • qui4
        		 2408 - 2938 (-) putative DNA-binding response regulator
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          • AET98904.1
          • qui5
          		 3055 - 3267 (-) MbtH-like protein
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            • AET98905.1
            • qui6
            		 3314 - 12751 (-) putative non-ribosomal peptide synthetase
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              • AET98906.1
              • qui7
              		 12759 - 20753 (-) putative non-ribosomal peptide synthetase
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                • AET98907.1
                • qui8
                		 20818 - 21516 (+) putative SAM-dependent methyltransferase
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                  • AET98908.1
                  • qui10
                  		 23150 - 25528 (+) UvrA-like protein
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                    • AET98909.1
                    • qui11
                    		 25610 - 26548 (+) putative oxidoreductase
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                      • AET98910.1
                      • qui12
                      		 26945 - 28333 (-) putative FAD-dependent oxidoreductase
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                        • AET98911.1
                        • qui13
                        		 28392 - 29480 (-) putative dehydrogenase
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                          • AET98912.1
                          • qui14
                          		 29477 - 30223 (-) putative thioesterase
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                            • AET98913.1
                            • qui15
                            		 30377 - 31582 (+) putative cytochrome P450
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                              • AET98914.1
                              • qui16
                              		 31596 - 33179 (+) putative AMP-binding ligase
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                                • AET98915.1
                                • qui17
                                		 33254 - 34078 (-) putative tryptophan 2,3-dioxygenase
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                                  • AET98916.1
                                  • qui18
                                  		 34133 - 35965 (+) putative non-ribosomal peptide synthetase
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                                    Biosynthesis information

                                    Biosynthetic modules

                                    Name
                                    Unk01
                                    Type
                                    nrps-type1
                                    Genes
                                    qui6
                                    Substrates
                                    cysteine (evidence: Structure-based inference, Sequence-based prediction)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk02
                                    Type
                                    nrps-type1
                                    Genes
                                    qui6
                                    Substrates
                                    valine (evidence: Structure-based inference, Sequence-based prediction)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk03
                                    Type
                                    nrps-type1
                                    Genes
                                    qui7
                                    Substrates
                                    serine (evidence: Structure-based inference, Sequence-based prediction)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk04
                                    Type
                                    nrps-type1
                                    Genes
                                    qui7
                                    Substrates
                                    alanine (evidence: Structure-based inference, Sequence-based prediction)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk05
                                    Type
                                    nrps-type1
                                    Genes
                                    qui16
                                    Substrates
                                    quinoxaline-2-carboxylic acid (evidence: Structure-based inference, Sequence-based prediction)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk06
                                    Type
                                    nrps-type1
                                    Genes
                                    qui18
                                    Substrates
                                    tryptophan (evidence: Mass spectrometry [1])
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Annotation changelog

                                    Entry version: 4

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-10-07
                                    Update chemical activity to schema version 2.11
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 3

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Updated bioactivity data
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2022-09-15
                                    Added NRP substrate specificities
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2019-10-16
                                    Migrated from v1.4
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2019-10-16
                                    Updated reference publication(s) (MIBiG Annotathon)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2015-06-12
                                    Submitted
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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