BGC0000418: ristocetin biosynthetic gene cluster from Amycolatopsis lurida
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Location: 1 - 80,193 nt. (total: 80,193 nt).
This entry is originally from NCBI GenBank KJ364518.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000418
Short description ristocetin biosynthetic gene cluster from Amycolatopsis lurida
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: KJ364518.1
Compounds
  • ristocetin
Species Amycolatopsis lurida [taxonomy]
References
Chemical products information
ristocetin
Copy SMILES
C95H110N8O44
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIE77051.1
 2314 - 3345 (+) VanH
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  • AIE77052.1
 3347 - 4387 (+) VanA
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  • AIE77053.1
 4384 - 4992 (+) VanX
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  • AIE77054.1
 6334 - 7125 (+) StrR family transcriptional regulator
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  • AIE77055.1
 7246 - 8097 (+) prephenate dehydrogenase
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  • AIE77056.1
 8410 - 10272 (+) ABC-transporter
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  • AIE77057.1
 10275 - 16457 (+) peptide synthetase
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  • AIE77058.1
 16454 - 19603 (+) peptide synthetase module 3
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  • AIE77059.1
 19978 - 31968 (+) peptide synthetase
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  • AIE77060.1
 32056 - 37617 (+) peptide synthetase module 7
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  • AIE77061.1
 37632 - 37841 (+) putative MbtH protein
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  • AIE77062.1
 38059 - 39234 (+) OxyA monooxygenase
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  • AIE77063.1
 39258 - 40415 (+) p450 monooxygenase-like protein
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  • AIE77064.1
 40405 - 41601 (+) p450 monooxygenase-like protein
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  • AIE77065.1
 41929 - 43170 (+) p450 monooxygenase-like protein
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  • AIE77066.1
 43183 - 44340 (+) glycosyltransferase
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  • AIE77067.1
 44371 - 45579 (+) glycosyltransferase
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  • AIE77068.1
 45601 - 46809 (+) glycosyltransferase
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  • AIE77069.1
 46836 - 47648 (+) methyltransferase
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  • AIE77070.1
 47669 - 48796 (+) glycosyltransferase
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  • AIE77071.1
 48907 - 49737 (+) hypothetical protein
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  • AIE77072.1
 49808 - 51535 (+) mannosyltransferase
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  • AIE77073.1
 51599 - 52639 (+) methyltransferase
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  • AIE77074.1
 52817 - 54103 (-) phenylglycine amino transferase
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  • AIE77075.1
 54274 - 55104 (+) alpha/beta hydrolase
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  • AIE77076.1
 55101 - 56837 (+) peptide synthetase
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  • AIE77077.1
 56852 - 58042 (+) p450 monooxygenase
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  • AIE77078.1
 58145 - 59206 (+) 4-hydroxyphenylpyruvate dioxygenase
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  • AIE77079.1
 59203 - 60273 (+) putative phenylglycolate oxidase
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  • AIE77080.1
 60279 - 61688 (+) putative NDP-hexose 2,3-dehydratase
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  • AIE77081.1
 61690 - 62655 (+) NAD-dependent epimerase dehydratase
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  • AIE77082.1
 62652 - 63761 (+) putative C-3 aminotransferase
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  • AIE77083.1
 63778 - 64395 (+) putative 3,5 epimerase
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  • AIE77084.1
 64592 - 66295 (+) mannosyltransferase
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  • AIE77085.1
 66547 - 67647 (+) dihydroxyphenylacetic acid synthase-like protein
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  • AIE77086.1
 67641 - 68303 (+) enoyl-CoA hydratase
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  • AIE77087.1
 68300 - 69517 (+) enoyl-CoA hydratase-like protein
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  • AIE77088.1
 69514 - 70311 (+) enoyl-CoA hydratase-like protein
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  • AIE77089.1
 70483 - 71565 (+) putative aldolase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
AIE77057.1
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
AIE77058.1
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
AIE77059.1
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
AIE77060.1
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
AIE77076.1
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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