BGC0000422: saframycin A biosynthetic gene cluster from Streptomyces lavendulae
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Location: 1 - 62,804 nt. (total: 62,804 nt).
This entry is originally from NCBI GenBank DQ838002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000422
Short description saframycin A biosynthetic gene cluster from Streptomyces lavendulae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
DQ838002.1
via
Compounds
  • saframycin A
  • saframycin B
Species Streptomyces lavendulae [taxonomy]
References
Chemical products information
saframycin A Evidence:
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C29H30N4O8
Chemical database entries
PubCHEM
PubCHEM
saframycin B Evidence:
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C28H31N3O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABQ41256.1
 245 - 1069 (-) tyrosinase
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    • ABQ41257.1
    		 1066 - 1488 (-) tyrosinase co-factor
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      • ABQ41258.1
      		 1663 - 2169 (-) putative translation initiation inhibitor
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        • ABQ41259.1
        		 2141 - 3703 (+) putative transcriptional regulator
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          • ABQ41260.1
          		 3929 - 5161 (+) hypothetical protein
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            • ABQ41261.1
            		 5283 - 5921 (-) putative methyltransferase
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              • ABQ41262.1
              		 6034 - 6405 (+) hypothetical protein
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                • ABQ42336.1
                		 6490 - 7125 (+) hypothetical protein
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                  • ABQ41263.1
                  		 7185 - 7598 (+) glyoxalase/bleomycin resistance protein/dioxygenase
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                    • ABI22116.1
                    		 7628 - 8062 (+) hypothetical protein
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                      • ABI22117.1
                      • sfmR1
                      		 8229 - 8816 (+) transcriptional regulator
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                        • ABI22118.1
                        • sfmO1
                        		 8813 - 9727 (+) oxidoreductase
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                          • ABI22119.1
                          • sfmR2
                          		 9930 - 10439 (+) transcriptional regulatory protein
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                            • ABI22120.1
                            • sfmCy1
                            		 10609 - 12147 (+) oxidoreductase
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                              • ABI22121.1
                              • sfmG
                              		 12181 - 13620 (+) transmembrane efflux protein
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                                • ABI22122.1
                                • sfmH
                                		 13732 - 16191 (-) UV-repair protein
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                                  • ABI22123.1
                                  • sfmO2
                                  		 16262 - 17827 (-) monooxygenase
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                                    • ABI22124.1
                                    • sfmM1
                                    		 17903 - 18502 (-) SAM-dependent methyltransferase
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                                      • ABI22125.1
                                      • sfmI
                                      		 18655 - 19137 (-) hypothetical protein
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                                        • ABI22126.1
                                        • sfmJ
                                        		 19134 - 19631 (-) pyridoxamine 5'-phosphate oxidase-related protein
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                                          • ABI22127.1
                                          • sfmO3
                                          		 19815 - 21002 (+) cytochrome P450 hydroxylase
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                                            • ABI22128.1
                                            • sfmK
                                            		 21056 - 21241 (+) ferredoxin-like protein
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                                              • ABI22129.1
                                              • sfmCy2
                                              		 21317 - 22831 (-) oxidoreductase
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                                                • ABI22130.1
                                                • sfmO4
                                                		 22963 - 24390 (-) cytochrome P450 hydroxylase
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                                                  • ABI22131.1
                                                  • sfmA
                                                  		 24414 - 29924 (+) putative non-ribosomal peptide synthetase
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                                                    • ABI22132.1
                                                    • sfmB
                                                    		 30061 - 33309 (+) putative non-ribosomal peptide synthetase
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                                                      • ABI22133.1
                                                      • sfmC
                                                      		 33306 - 37763 (+) putative non-ribosomal peptide synthetase
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                                                        • ABI22134.1
                                                        • sfmD
                                                        		 37760 - 38857 (+) hypothetical protein
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                                                          • ABI22135.1
                                                          • sfmE
                                                          		 38854 - 41223 (+) putative peptidase
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                                                            • ABI22136.1
                                                            • sfmF
                                                            		 41220 - 41441 (+) MbtH-like domain protein
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                                                              • ABI22137.1
                                                              • sfmM2
                                                              		 41474 - 42574 (+) methyltransferase
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                                                                • ABI22138.1
                                                                • sfmR3
                                                                		 42666 - 43202 (+) transcriptional regulatory protein
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                                                                  • ABI22139.1
                                                                  • sfmO5
                                                                  		 43343 - 44512 (-) prephenate dehydrogenase
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                                                                    • ABI22140.1
                                                                    • sfmS1
                                                                    		 44539 - 45993 (-) putative adenosylhomocysteinase
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                                                                      • ABI22141.1
                                                                      • sfmS2
                                                                      		 46023 - 46964 (-) N5, N10-methylen-tetrahydrofolate reductase
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                                                                        • ABI22142.1
                                                                        • sfmS3
                                                                        		 47000 - 50383 (-) putative methionine synthase
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                                                                          • ABI22143.1
                                                                          • sfmS4
                                                                          		 50479 - 51462 (-) putative adenosine kinase
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                                                                            • ABI22144.1
                                                                            • sfmS5
                                                                            		 51464 - 52669 (-) putative S-adenosylmethionine synthetase
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                                                                              • ABI22145.1
                                                                              • sfmM3
                                                                              		 52690 - 53694 (-) SAM-dependent methyltransferase
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                                                                                • ABI22146.1
                                                                                • sfmO6
                                                                                		 54002 - 55132 (+) oxygenase
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                                                                                  • ABI22147.1
                                                                                  		 55498 - 55959 (+) cofilin
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                                                                                    • ABI22148.1
                                                                                    		 55865 - 56869 (-) putative RNA polymerase ECF-subfamily sigma factor
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                                                                                      • ABQ41264.1
                                                                                      		 57211 - 57681 (+) putative DNA ligase
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                                                                                        • ABQ41265.1
                                                                                        		 57871 - 58239 (-) hypothetical protein
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                                                                                          • ABQ41266.1
                                                                                          		 58327 - 59604 (+) unknonw
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                                                                                            • ABQ41267.1
                                                                                            		 60002 - 60475 (+) neuromedin U receptor 1
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                                                                                              • ABQ41268.1
                                                                                              		 60426 - 60995 (-) hypothetical protein
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                                                                                                Biosynthesis information

                                                                                                Biosynthetic modules

                                                                                                Name
                                                                                                Unk01
                                                                                                Type
                                                                                                nrps-type1
                                                                                                Genes
                                                                                                sfmA
                                                                                                Substrates
                                                                                                alanine (evidence: ATP-PPi exchange assay, Structure-based inference, Homology)
                                                                                                Integrated Monomers
                                                                                                Domains
                                                                                                adenylation
                                                                                                Name
                                                                                                Unk02
                                                                                                Type
                                                                                                nrps-type1
                                                                                                Genes
                                                                                                sfmB
                                                                                                Substrates
                                                                                                glycine (evidence: ATP-PPi exchange assay, Structure-based inference, Homology)
                                                                                                Integrated Monomers
                                                                                                Domains
                                                                                                adenylation
                                                                                                Name
                                                                                                Unk03
                                                                                                Type
                                                                                                nrps-type1
                                                                                                Genes
                                                                                                sfmC
                                                                                                Substrates
                                                                                                3-hydroxy-O-methyl-5-methyltyrosine (evidence: ATP-PPi exchange assay, Structure-based inference, Homology)
                                                                                                Integrated Monomers
                                                                                                Domains
                                                                                                adenylation
                                                                                                Annotation changelog

                                                                                                Entry version: next

                                                                                                Date
                                                                                                Changes
                                                                                                Submitters
                                                                                                Reviewers
                                                                                                2024-05-15
                                                                                                MIBiG v4 annotathon
                                                                                                • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                Entry version: 4

                                                                                                Date
                                                                                                Changes
                                                                                                Submitters
                                                                                                Reviewers
                                                                                                2022-10-07
                                                                                                Update chemical activity to schema version 2.11
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                Entry version: 3

                                                                                                Date
                                                                                                Changes
                                                                                                Submitters
                                                                                                Reviewers
                                                                                                2022-09-15
                                                                                                Updated bioactivity data
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                2022-09-15
                                                                                                Added NRP substrate specificities
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                Entry version: 2

                                                                                                Date
                                                                                                Changes
                                                                                                Submitters
                                                                                                Reviewers
                                                                                                2019-10-16
                                                                                                Migrated from v1.4
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                2019-10-16
                                                                                                Updated compound(s) information (NPAtlas curation)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                Entry version: 1

                                                                                                Date
                                                                                                Changes
                                                                                                Submitters
                                                                                                Reviewers
                                                                                                2015-06-12
                                                                                                Submitted
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                Detailed domain annotation
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