BGC0000424: serobactin C biosynthetic gene cluster from Herbaspirillum seropedicae SmR1
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Location: 2,645,251 - 2,687,402 nt. (total: 42,152 nt).
This entry is originally from NCBI GenBank CP002039.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000424
Short description serobactin C biosynthetic gene cluster from Herbaspirillum seropedicae SmR1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (NRP siderophore)
Loci NCBI GenBank: CP002039.1
Compounds
  • serobactin C
  • serobactin B
  • serobactin A
Species Herbaspirillum seropedicae SmR1 [taxonomy]
References
Chemical products information
serobactin C
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C37H63N7O17
serobactin B
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C35H59N7O17
serobactin A
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C33H55N7O17
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Hsero_2337
  • ADJ63836.1
  • cirA
 2645251 - 2647749 (+) TonB-dependent transducer
  • Regulation
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  • Hsero_2338
  • ADJ63837.1
  • pfrI
 2647830 - 2648366 (+) ferric regulator sigma-24 subunit protein
  • Regulation
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  • Hsero_2339
  • ADJ63838.1
 2648532 - 2648753 (+) MbtH-like protein
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  • Hsero_2340
  • ADJ63839.1
 2648760 - 2649509 (+) thioesterase involved in non-ribosomal peptide biosynthesis protein
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  • Hsero_2341
  • ADJ63840.1
 2649511 - 2650191 (+) 4'-phosphopantetheinyl transferase protein
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  • Hsero_2342
  • ADJ63841.1
 2650197 - 2651225 (+) clavaminic acid synthetase (CAS)-like protein
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • Hsero_2343
  • ADJ63842.1
 2651343 - 2678825 (+) Serobactin synthetase
  • Scaffold biosynthesis
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  • Hsero_2344
  • ADJ63843.1
 2679043 - 2679996 (-) esterase/lipase protein
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  • Hsero_2345
  • ADJ63844.1
  • fhuA
 2680085 - 2682202 (-) TonB-dependent Fe3+-serobactin transporter
  • Transport
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  • Hsero_2346
  • ADJ63845.1
 2682281 - 2683612 (-) L-ornithine N5-monooxygenase protein
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • Hsero_2347
  • ADJ63846.1
 2683634 - 2684638 (-) acetyltransferases, including N-acetylases of ribosomal proteins
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  • Hsero_2348
  • ADJ63847.1
 2684744 - 2685556 (-) iron reductase protein
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  • Hsero_2349
  • ADJ63848.1
  • pvdE
 2685720 - 2687402 (+) ABC-type siderophore (cyclic peptide) export system protein
  • Transport
Sequence-based prediction
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NRP-specific information
Subclass NRP siderophore
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
Hsero_2343
Module 1
Specificity: 3-hydroxyaspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Module 2
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: DCL
Module 3
Specificity: 3-hydroxyaspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Modification domains: Hydroxylation
Module 4
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Module 5
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: DCL
Module 6
Specificity: N5-hydroxyornithine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Genes encoding specified AA: Hsero_2346
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 2EUPHFNFSB4J4GBDL2SYVJGJ, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected NRP gene names
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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