BGC0000430: spumigin E biosynthetic gene cluster from Nodularia spumigena CCY9414
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Location: 4,953,880 - 4,975,880 nt. (total: 22,001 nt).
This entry is originally from NCBI GenBank CP007203.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000430
Short description spumigin E biosynthetic gene cluster from Nodularia spumigena CCY9414
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: CP007203.2
Compounds
  • spumigin E
Species Nodularia spumigena CCY9414 [taxonomy]
References
Chemical products information
spumigin E
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C31H42N6O7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • NSP_49190
  • AHJ31211.1
 4953880 - 4955931 (-) ABC transporter ATP-binding protein
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  • NSP_49200
  • AHJ31212.1
 4956128 - 4956943 (-) Pyrroline-5-carboxylate reductase
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  • NSP_49210
  • AHJ31213.1
 4957066 - 4958169 (-) Sorbitol dehydrogenase
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  • NSP_49220
  • AHJ31214.1
 4958300 - 4959094 (-) hypothetical protein
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  • NSP_49230
  • AHJ31215.1
 4959157 - 4971672 (-) Long-chain-fatty-acid--CoA ligase
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  • NSP_49240
  • AHJ31216.1
 4971674 - 4972474 (-) lichenysin synthetase A
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  • NSP_49250
  • AHJ31217.1
 4972452 - 4975880 (-) Long-chain-fatty-acid--CoA ligase
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Polyketide-specific information
Subclass Other
Starter unit 4-hydroxyphenylpyruvate
Cyclic? no
Polyketide-synthases
Genes Properties Modules
NSP_49250 Synthase subclass: Modular type I
Module 0
Specificity: 4-hydroxyphenylpyruvate
Evidence for specificity: Activity assay
Genes: NSP_49250
Core domains: CoA-ligase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Reductive release
NRP-synthases
Gene Modules
NSP_49230
Module 1
Specificity: homotyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 2
Specificity: proline
Evidence for specificity:
  • Activity assay
Condensation domain type: DCL
Module 3
Specificity: arginine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: BAJIZJS2YANDM4M7JHS5DFUK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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