BGC0000431: stenothricin biosynthetic gene cluster from Streptomyces filamentosus NRRL 15998
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Location: 870,145 - 925,039 nt. (total: 54,895 nt).
This entry is originally from NCBI GenBank DS999644.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000431
Short description stenothricin biosynthetic gene cluster from Streptomyces filamentosus NRRL 15998
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
Loci NCBI GenBank: DS999644.1
Compounds
  • stenothricin
Species Streptomyces filamentosus NRRL 15998 [taxonomy]
References
Chemical products information
stenothricin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSGG_00659
  • EFE73293.1
 870145 - 871689 (-) transmembrane-transport protein
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  • SSGG_00660
  • EFE73294.1
 871686 - 872255 (-) TetR-family transcriptional regulator
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  • SSGG_00661
  • EFE73295.1
 872503 - 874668 (+) conserved hypothetical protein
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  • SSGG_00662
  • EFE73296.1
 874699 - 875730 (-) oxidoreductase
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  • SSGG_00663
  • EFE73297.1
 875787 - 877214 (-) argininosuccinate lyase ArgH
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  • SSGG_00664
  • EFE73298.1
 877337 - 878533 (-) argininosuccinate synthase ArgG
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  • SSGG_00665
  • EFE73299.1
 878620 - 880008 (+) predicted protein
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  • SSGG_00666
  • EFE73300.1
 880090 - 880800 (+) secreted protein
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  • SSGG_00667
  • EFE73301.1
 880811 - 881347 (-) arginine repressor
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  • SSGG_00668
  • EFE73302.1
 881373 - 882584 (-) N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase ArgD
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  • SSGG_00669
  • EFE73303.1
 882581 - 883525 (-) N-acetylglutamate kinase ArgB
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  • SSGG_00670
  • EFE73304.1
 883522 - 884676 (-) N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase ArgJ
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  • SSGG_00671
  • EFE73305.1
 884673 - 885698 (-) N-acetyl-gamma-glutamylphosphate reductase
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  • SSGG_00672
  • EFE73306.1
 885809 - 886816 (-) cysteine synthase
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  • SSGG_00673
  • EFE73307.1
 886833 - 887888 (-) ornithine cyclodeaminase
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  • SSGG_00674
  • EFE73308.1
 887981 - 891535 (-) non-ribosomal peptide synthetase
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  • SSGG_00675
  • EFE73309.1
 892183 - 892998 (+) conserved hypothetical protein
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  • SSGG_00676
  • EFE73310.1
 893254 - 893481 (+) conserved hypothetical protein
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  • SSGG_00677
  • EFE73311.1
 893511 - 893681 (+) predicted protein
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  • SSGG_00678
  • EFE73312.1
 893801 - 912049 (+) nonribosomal peptide synthetase
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  • SSGG_00679
  • EFE73313.1
 912049 - 923700 (+) nonribosomal peptide synthetase
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  • SSGG_00680
  • EFE73314.1
 923744 - 925039 (+) pyridoxal-5'-phosphate-dependent enzyme
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NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
NRP-synthases
Gene Modules
SSGG_00674
Module 0
Specificity: cysteic acid
Evidence for specificity:
  • Structure-based inference
SSGG_00678
Module 1
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Module 2
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 3
Specificity: 2,3-diaminopropionic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 4
Condensation domain type: LCL
Module 5
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 6
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
SSGG_00679
Module 7
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 8
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 9
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UK5BZZ5BLXFR5LGS2GITT5IB, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove negative molecular mass
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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