BGC0000440

BGC0000440: Teicoplanin A2-1 biosynthetic gene cluster from Actinoplanes teichomyceticus

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Location: 1 - 89,713 nt. (total: 89,713 nt).
This entry is originally from NCBI GenBank AJ605139.1.

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NRPS/PKS domains

General information about the BGC

MIBiG accession	BGC0000440
Short description	Teicoplanin A2-1 biosynthetic gene cluster from Actinoplanes teichomyceticus
Status	Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: complete Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	NRPS (Type I)
Loci	AJ605139.1 via Enzymatic assays
Compounds	Teicoplanin A2-1 Teicoplanin A2-2 Teicoplanin A2-3 Teicoplanin A2-4 Teicoplanin A2-5
Species	Actinoplanes teichomyceticus [taxonomy]
References	[1] Identification of a Deacetylase Involved in the Maturation of Teicoplanin. Truman, A et al., ChemBioChem (2006) DOI:10.1002/cbic.200600308 [2] Structure and mechanism of action of teicoplanin. Parenti, F, Journal of Hospital Infection (1986) DOI:10.1016/0195-6701(86)90011-3 [3] Crystal Structures of Lipoglycopeptide Antibiotic Deacetylases: Implications for the Biosynthesis of A40926 and Teicoplanin. Zou, Y et al., Chemistry & Biology (2008) DOI:10.1016/J.CHEMBIOL.2008.05.009 [4] Biosynthetic Gene Cluster of the Glycopeptide Antibiotic TeicoplaninCharacterization of Two Glycosyltransferases and the Key Acyltransferase. LI, T et al., Chemistry & Biology (2004) DOI:10.1016/S1074-5521(04)00002-X [5] Tailoring of Glycopeptide Scaffolds by the Acyltransferases from the Teicoplanin and A-40,926 Biosynthetic Operons. Kruger, R et al., Chemistry & Biology (2005) DOI:10.1016/j.chembiol.2004.12.005 [6] Biosynthetic Gene Cluster of the Glycopeptide Antibiotic TeicoplaninCharacterization of Two Glycosyltransferases and the Key Acyltransferase. LI, T et al., Chemistry & Biology (2004) DOI:10.1016/s1074-5521(04)00002-x [7] Structure of the major glycopeptide of the teicoplanin complex. Hunt, A et al., Journal of the American Chemical Society (1984) DOI:10.1021/ja00329a043 [8] Kinetic Analysis of Teicoplanin Glycosyltransferases and Acyltransferase Reveal Ordered Tailoring of Aglycone Scaffold to Reconstitute Mature Teicoplanin. Howard-Jones, A et al., Journal of the American Chemical Society (2007) DOI:10.1021/ja0735857 [9] Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus. Sosio, M et al., Microbiology (2004) DOI:10.1099/mic.0.26507-0 [10] Structure and conformation of epimers derived from the antibiotic teicoplanin. BARNA, J et al., The Journal of Antibiotics (1984) DOI:10.7164/antibiotics.37.1204 [11] Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus. Sosio M et al., Microbiology (Reading) (2004) PMID:14702401 [12] Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. Li TL et al., Chem Biol (2004) PMID:15113000 [13] Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis. Donadio S et al., Mol Genet Genomics (2005) PMID:16007453 [14] Identification of a deacetylase involved in the maturation of teicoplanin. Truman AW et al., Chembiochem (2006) PMID:17009278 [15] Glycopeptide biosynthesis: Dbv21/Orf2 from dbv/tcp gene clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase. Ho JY et al., J Am Chem Soc (2006) PMID:17044690 [16] Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesis. Haslinger K et al., Chembiochem (2014) PMID:25358800

Chemical products information

Teicoplanin A2-1 Evidence: NMR [2], [7], [10]

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C₈₈H₉₅Cl₂N₉O₃₃