BGC0000452: tyrocidine biosynthetic gene cluster from Brevibacillus brevis NBRC 100599
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Location: 2,867,472 - 2,916,558 nt. (total: 49,087 nt).
This entry is originally from NCBI GenBank AP008955.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000452
Short description tyrocidine biosynthetic gene cluster from Brevibacillus brevis NBRC 100599
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AP008955.1
2867472 - 2916558
via
Compounds
  • tyrocidine
Species Brevibacillus brevis NBRC 100599 [taxonomy]
References
Chemical products information
tyrocidine Evidence:
Copy SMILES
C66H87N13O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBR47_27790
  • BAH43756.1
 2867472 - 2869136 (+) hypothetical protein
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    • BBR47_27800
    • BAH43757.1
    		 2869274 - 2869480 (+) putative truncated ABC transporter ATP-binding protein
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      • BBR47_27810
      • BAH43758.1
      		 2869578 - 2870147 (+) putative truncated ABC transporter ATP-binding protein
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        • BBR47_27820
        • BAH43759.1
        • tyrS
        		 2870409 - 2871677 (+) tyrosyl-tRNA synthetase
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          • BBR47_27830
          • BAH43760.1
          		 2871742 - 2873856 (-) hypothetical protein
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            • BBR47_27840
            • BAH43761.1
            		 2873934 - 2874299 (+) putative transcriptional regulator
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              • BBR47_27850
              • BAH43762.1
              		 2874303 - 2875493 (+) conserved hypothetical membrane protein
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                • BBR47_27860
                • BAH43763.1
                		 2875714 - 2875821 (+) hypothetical protein
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                  • BBR47_27870
                  • BAH43764.1
                  • tycA
                  		 2876081 - 2879359 (+) tyrocidine synthetase I
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                    • BBR47_27880
                    • BAH43765.1
                    • tycB
                    		 2879454 - 2890223 (+) tyrocidine synthetase II
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                      • BBR47_27890
                      • BAH43766.1
                      • tycC
                      		 2890329 - 2909792 (+) tyrocidine synthetase III
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                        • BBR47_27900
                        • BAH43767.1
                        • tycD
                        		 2909876 - 2911657 (+) ABC transporter ATP binding/permease protein
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                          • BBR47_27910
                          • BAH43768.1
                          • tycE
                          		 2911708 - 2913459 (+) ABC transporter ATP-binding/permease protein
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                            • BBR47_27920
                            • BAH43769.1
                            		 2913456 - 2914148 (+) probable 4'-phosphopantetheinyl transferase
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                              • BBR47_27930
                              • BAH43770.1
                              • tycF
                              		 2914194 - 2914922 (+) putative type II thioesterase
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                                • BBR47_27940
                                • BAH43771.1
                                		 2914975 - 2916558 (+) conserved hypothetical protein
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  tycA
                                  Substrates
                                  phenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  tycB
                                  Substrates
                                  proline (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk04
                                  Type
                                  nrps-type1
                                  Genes
                                  tycB
                                  Substrates
                                  phenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk05
                                  Type
                                  nrps-type1
                                  Genes
                                  tycB
                                  Substrates
                                  phenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk06
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  asparagine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk07
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  asparagine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk08
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  glutamine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk09
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  glutamine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk10
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk11
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  tyrosine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk12
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  valine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk13
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  valine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk14
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  ornithine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk15
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  ornithine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk16
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  leucine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk17
                                  Type
                                  nrps-type1
                                  Genes
                                  tycC
                                  Substrates
                                  leucine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Updated bioactivity data
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2019-10-16
                                  Updated reference publication(s) (MIBiG Annotathon)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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