BGC0000458: viomycin biosynthetic gene cluster from Streptomyces vinaceus
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Location: 1 - 36,401 nt. (total: 36,401 nt).
This entry is originally from NCBI GenBank AY263398.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000458
Short description viomycin biosynthetic gene cluster from Streptomyces vinaceus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AY263398.1
Compounds
  • viomycin
Species Streptomyces vinaceus [taxonomy]
References
Chemical products information
viomycin
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C25H45N13O14S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAP92491.1
  • vioA
 415 - 6786 (+) nonribosomal peptide synthetase
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  • AAP92492.1
  • vioB
 6981 - 8021 (+) 2,3-diaminopropionate synthase
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  • AAP92493.1
  • vioC
 8018 - 9094 (+) L-arginine beta-hydroxylase
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  • AAP92494.1
  • vioD
 9091 - 10260 (+) capreomycidine synthase
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  • AAP92495.1
  • vioE
 10257 - 11600 (+) permease
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  • AAP92496.1
  • vioF
 11597 - 14818 (+) nonribosomal peptide synthetase
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  • AAP92497.1
  • vioG
 14908 - 18174 (+) nonribosomal peptide synthetase
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  • AAP92498.1
  • vioH
 18171 - 18959 (+) type II thioesterase
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  • AAP92499.1
  • vioI
 18956 - 20608 (+) nonribosomal peptide synthetase
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  • AAP92500.1
  • vioJ
 20605 - 21777 (+) 2,3-diaminopropionate alpha,beta-desaturase
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  • AAP92501.1
  • vioK
 21827 - 22909 (+) ornithine cyclodeaminase
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  • AAP92502.1
  • vioL
 22906 - 23832 (+) carbamoyltransferase
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  • AAP92503.1
  • vioM
 23829 - 25202 (+) nonribosomal peptide synthetase
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  • AAP92504.1
  • vioN
 25199 - 25390 (+) hypothetical protein
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  • AAP92505.1
  • vioO
 25396 - 27228 (+) nonribosomal peptide synthetase
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  • AAP92506.1
  • vioP
 27303 - 28640 (+) lysine 2,3-aminomutase
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  • AAP92507.1
  • vph
 28676 - 29557 (-) viomycin phosphotransferase
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  • AAP92508.1
  • vioQ
 29590 - 30621 (+) capreomycidine hydroxylase
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  • AAP92509.1
  • vioR
 30660 - 31370 (-) transcriptional regulator
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  • AAP92510.1
  • vioS
 31752 - 33110 (+) viomycin phosphate phosphatase
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  • AAP92511.1
  • vioT
 33717 - 36299 (-) transcriptional regulator
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
vioA
Module ?
Specificity: serine
Evidence for specificity:
Module ?
Specificity: serine
Evidence for specificity:
vioO
Module ?
Specificity: beta-lysine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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