BGC0000469: bottromycin A2 biosynthetic gene cluster from Streptomyces sp. BC16019
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Location: 16,119 - 37,000 nt. (total: 20,882 nt).
This entry is originally from NCBI GenBank JX235926.1.

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core biosynthetic genes
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transport-related genes
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General
Compounds
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Biosynthesis
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000469
Short description bottromycin A2 biosynthetic gene cluster from Streptomyces sp. BC16019
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
JX235926.1
16255 - 33922
via Heterologous expression
Compounds
  • bottromycin A2
Species Streptomyces sp. BC16019 [taxonomy]
References
Chemical products information
bottromycin A2 Evidence:
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C42H62N8O7S1
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFV25478.1
  • botT
 16255 - 17550 (-) BotT
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    • AFV25479.1
    • botOMT
    		 18069 - 18908 (-) Methyltransferase
    • Methylation
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    • AFV25480.1
    • botRMT1
    		 19314 - 21239 (+) Methyltransferase
    • Methylation
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    • AFV25481.1
    • botA
    		 21336 - 21470 (+) precursor peptide
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      • AFV25482.1
      • botC
      		 21534 - 22838 (+) Heterocyclase
      • Heterocyclization
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      • AFV25483.1
      • botCD
      		 22951 - 24153 (+) Cyclase
      • Cyclization
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      • AFV25484.1
      • botRMT2
      		 24150 - 26132 (+) Methyltransferase
      • Methylation
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      • AFV25485.1
      • botH
      		 26119 - 27000 (+) Epimerase
      • Epimerization
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      • AFV25486.1
      • botAH
      		 27018 - 28415 (+) Hydrolase
      • Hydrolysis
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      • AFV25487.2
      • botCYP
      		 28405 - 29631 (+) Decarboxylation|Oxidation
      • Decarboxylation
      • Oxidation
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      • AFV25488.1
      • botRMT3
      		 29639 - 31684 (+) Methyltransferase
      • Methylation
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      • AFV25489.1
      • botR
      		 31849 - 32403 (+) BotR
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        • AFV25490.1
        • botP
        		 32408 - 33922 (+) Hydrolase
        • Hydrolysis
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        Biosynthesis information

        No biosynthesis information available for this record.

        Annotation changelog

        Entry version: 6

        Date
        Changes
        Submitters
        Reviewers
        2024-07-24
        MIBiG v4 annotathon
        • (ID: C62OJVVH7XOTOTFZSJT727YU)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: next

        Date
        Changes
        Submitters
        Reviewers
        2023-11-17
        Specified biological target, specified start/stop of BGC, added RiPP and gene annotations. Added a review paper (doi:10.1039/D0NP00097C) which unifies the bottromycin gene designation.
        • (ID: C62OJVVH7XOTOTFZSJT727YU)
        • (ID: DKBFG3K6XTYSVEQEQVCFZBWY)

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Updated bioactivity data
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2019-10-16
        Updated compound(s) information (NPAtlas curation)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2015-06-12
        Submitted
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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