BGC0000535: nisin A biosynthetic gene cluster from Lactococcus lactis subsp. lactis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 15,016 nt. (total: 15,016 nt).
This entry is originally from NCBI GenBank HM219853.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000535
Short description nisin A biosynthetic gene cluster from Lactococcus lactis subsp. lactis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
HM219853.1
via Gene expression correlated with compound production
Compounds
  • nisin A
Species Lactococcus lactis subsp. lactis [taxonomy]
References
Chemical products information
nisin A Evidence:
Copy SMILES
C143H230N42O37S7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADJ56352.1
  • nisA
 828 - 1001 (+) NisA
  • Precursor biosynthesis
  • Knock-out Activity assay
copy AA seq
copy Nt seq
  • ADJ56353.1
  • nisB
 1109 - 4090 (+) NisB
  • Tailoring
  • Knock-out Activity assay
copy AA seq
copy Nt seq
  • ADJ56354.1
  • nisT
 4101 - 5903 (+) NisT
  • Transport
  • Knock-out Activity assay
copy AA seq
copy Nt seq
  • ADJ56355.1
  • nisC
 5896 - 7140 (+) NisC
  • Tailoring
  • Knock-out Activity assay
copy AA seq
copy Nt seq
  • ADJ56356.1
  • nisI
 7137 - 7874 (+) NisI
  • Resistance/immunity
  • Knock-out Activity assay
copy AA seq
copy Nt seq
  • ADJ56357.1
  • nisP
 7876 - 9924 (+) NisP
    copy AA seq
    copy Nt seq
    • ADJ56358.1
    • nisR
    		 9993 - 10679 (+) NisR
    • Regulation
    • Knock-out Activity assay
    copy AA seq
    copy Nt seq
    • ADJ56359.1
    • nisK
    		 10672 - 12015 (+) NisK
    • Regulation
    • Knock-out Activity assay
    copy AA seq
    copy Nt seq
    • ADJ56360.1
    • nisF
    		 12114 - 12791 (+) NisF
    • Resistance/immunity
    • Knock-out Activity assay
    copy AA seq
    copy Nt seq
    • ADJ56361.1
    • nisE
    		 12793 - 13521 (+) NisE
    • Resistance/immunity
    • Knock-out Activity assay
    copy AA seq
    copy Nt seq
    • ADJ56362.1
    • nisG
    		 13508 - 14152 (+) NisG
    • Resistance/immunity
    • Knock-out Activity assay
    copy AA seq
    copy Nt seq
    Biosynthesis information
    Annotation changelog

    Entry version: 3

    Date
    Changes
    Submitters
    Reviewers
    2022-10-07
    Update chemical activity to schema version 2.11
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 2

    Date
    Changes
    Submitters
    Reviewers
    2019-10-16
    Migrated from v1.4
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 1

    Date
    Changes
    Submitters
    Reviewers
    2015-06-12
    Submitted
    • (ID: AFPZZIRFJ6UKQGITNCDTFELO)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    Similar known gene clusters from MIBiG 4.0
    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
    Click on reference genes to show details of similarities to genes within the current region.
    Click on an accession to open that entry in the MiBIG database.